Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment

Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment

Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and ra...

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Veröffentlicht in:Experimental Oncology
Datum:2013
Hauptverfasser: Subramanyam D., Subbaiah, K.C.V., Rajendra W., Lokanatha V.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
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Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/145238
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145238
record_format dspace
spelling Subramanyam D.
Subbaiah, K.C.V.
Rajendra W.
Lokanatha V.
2019-01-19T18:28:16Z
2019-01-19T18:28:16Z
2013
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145238
Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P << 0,001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P << 0,05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy.
The authors are thankful to Dr. D.S. Raju Naidu and Dr. P. Chandra Sekharan for providing cervical cancer samples. The authors also thanks to Institutional Ethical committee (IEC), S.V. Medical College, for providing ethical clearance and UGC-BSR-Non-SAP for providing financial assistance.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
spellingShingle Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
Subramanyam D.
Subbaiah, K.C.V.
Rajendra W.
Lokanatha V.
Original contributions
title_short Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
title_full Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
title_fullStr Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
title_full_unstemmed Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
title_sort serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment
author Subramanyam D.
Subbaiah, K.C.V.
Rajendra W.
Lokanatha V.
author_facet Subramanyam D.
Subbaiah, K.C.V.
Rajendra W.
Lokanatha V.
topic Original contributions
topic_facet Original contributions
publishDate 2013
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim - in the present study, the effect of chemo and radio therapies on serum trace elements content and antioxidant activity in blood serum of cervical cancer patients was evaluated. Among 104 cervical cancer patients selected for the present study, 54 and 50 patients were treated with chemo- and radiotherapy respectively. Plasma Se, Zn, Cu and some enzymatic antioxidants activities were estimated in serum before and after the treatment. The decreased levels of serum trace elements, glutathione peroxidase activity and total antioxidant capacity, and increased malondialdehyde, glutathion reductase was observed in cervical cancer patients when compared to healthy controls. The increased concentration of serum Se, Zn was observed in patients treated with chemotherapy. Simultaneously there was a significant (P << 0,001) increase in glutathione peroxidase and total antioxidant capacity, and significant decrease (P << 0,05) in malondialdehyde and glutathion reductase levels in the serum of patients treated with chemotherapy compared to the patients treated with radiotherapy.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145238
fulltext
citation_txt Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment / D. Subramanyam, K.C.V. Subbaiah, W. Rajendra, V. Lokanatha // Experimental oncology. — 2013. — Т. 35, № 2. — С. 97-100. — Бібліогр.: 30 назв. — англ.
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first_indexed 2025-11-25T20:55:02Z
last_indexed 2025-11-25T20:55:02Z
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