Antibodies against benzo

• Published in: Experimental Oncology
• Date: 2013
• Main Authors: Ustinov, V.A., Matveeva, V.A., Kostyanko, M.A., Glushkov, A.N.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145239
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Antibodies against benzo / V.A. Ustinov, V.A. Matveeva, M.A. Kostyanko, A.N. Glushkov // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 207-210. — Бібліогр.: 16 назв. — англ.

Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials and Methods: The Ab1 and AM levels were measured by non-competitive ELISA in blood serum of 10 mice immunized with BP-protein conjugate, and in blood serum of 288 healthy persons and 165 lung cancer patients. Results: The Ab] level of was 2-fold higher than Ab2 level in blood serum of BP-immunized mice. In lung cancer patients the Ab1 level was almost 3 times higher and the Ab2 level was by 30% higher than these indexes in healthy individuals. The Ab1/Ab2 ratio was 2 in BP-immunized mice and healthy individuals and l in lung cancer patients. Conclusion: Our data have shown that the Ab1/Ab2 ratio in lung cancer patients differ from that in healthy individuals and is close to the Ab1/Ab2 ratio in BP-immunized mouse. Key Words: benzo[a]pyrene, antibodies, lung cancer.