Antibodies against benzo
Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials and Methods: The Ab1 and AM levels were measured by non-competitive ELISA in blo...
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| Published in: | Experimental Oncology |
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| Date: | 2013 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145239 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Antibodies against benzo / V.A. Ustinov, V.A. Matveeva, M.A. Kostyanko, A.N. Glushkov // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 207-210. — Бібліогр.: 16 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1859895562853154816 |
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| author | Ustinov, V.A. Matveeva, V.A. Kostyanko, M.A. Glushkov, A.N. |
| author_facet | Ustinov, V.A. Matveeva, V.A. Kostyanko, M.A. Glushkov, A.N. |
| citation_txt | Antibodies against benzo / V.A. Ustinov, V.A. Matveeva, M.A. Kostyanko, A.N. Glushkov // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 207-210. — Бібліогр.: 16 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials and Methods: The Ab1 and AM levels were measured by non-competitive ELISA in blood serum of 10 mice immunized with BP-protein conjugate, and in blood serum of 288 healthy persons and 165 lung cancer patients. Results: The Ab] level of was 2-fold higher than Ab2 level in blood serum of BP-immunized mice. In lung cancer patients the Ab1 level was almost 3 times higher and the Ab2 level was by 30% higher than these indexes in healthy individuals. The Ab1/Ab2 ratio was 2 in BP-immunized mice and healthy individuals and l in lung cancer patients. Conclusion: Our data have shown that the Ab1/Ab2 ratio in lung cancer patients differ from that in healthy individuals and is close to the Ab1/Ab2 ratio in BP-immunized mouse. Key Words: benzo[a]pyrene, antibodies, lung cancer.
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| first_indexed | 2025-12-07T15:54:54Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-145239 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T15:54:54Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Ustinov, V.A. Matveeva, V.A. Kostyanko, M.A. Glushkov, A.N. 2019-01-19T20:48:59Z 2019-01-19T20:48:59Z 2013 Antibodies against benzo / V.A. Ustinov, V.A. Matveeva, M.A. Kostyanko, A.N. Glushkov // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 207-210. — Бібліогр.: 16 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145239 Aim: To evaluate the production of antibodies against benzo[a]pyrene (BF) (Ab1) and corresponding antiidiotypic antibodies (AM) in mice after immunization with BP-protein conjugate and in lung cancer patients. Materials and Methods: The Ab1 and AM levels were measured by non-competitive ELISA in blood serum of 10 mice immunized with BP-protein conjugate, and in blood serum of 288 healthy persons and 165 lung cancer patients. Results: The Ab] level of was 2-fold higher than Ab2 level in blood serum of BP-immunized mice. In lung cancer patients the Ab1 level was almost 3 times higher and the Ab2 level was by 30% higher than these indexes in healthy individuals. The Ab1/Ab2 ratio was 2 in BP-immunized mice and healthy individuals and l in lung cancer patients. Conclusion: Our data have shown that the Ab1/Ab2 ratio in lung cancer patients differ from that in healthy individuals and is close to the Ab1/Ab2 ratio in BP-immunized mouse. Key Words: benzo[a]pyrene, antibodies, lung cancer. This study was supported by the RFFI grant number 10—04—98003 r_sibir_a — Regional Competition SIBERIA. We especially thank Sherina EA and Gurov E.A. for fruitful help in ELISA. Also we would like to thank Titov V.A for the samples of lung cancer patients blood and healthy people blood. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Antibodies against benzo Article published earlier |
| spellingShingle | Antibodies against benzo Ustinov, V.A. Matveeva, V.A. Kostyanko, M.A. Glushkov, A.N. Original contributions |
| title | Antibodies against benzo |
| title_full | Antibodies against benzo |
| title_fullStr | Antibodies against benzo |
| title_full_unstemmed | Antibodies against benzo |
| title_short | Antibodies against benzo |
| title_sort | antibodies against benzo |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145239 |
| work_keys_str_mv | AT ustinovva antibodiesagainstbenzo AT matveevava antibodiesagainstbenzo AT kostyankoma antibodiesagainstbenzo AT glushkovan antibodiesagainstbenzo |