Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation

Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
 significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
 under RF-EMR exposure...

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Збережено в:
Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2013
Автори: Burlaka, A., Tsybulin, O., Sidorik, E., Lukin, S., Polishuk, V., Tsehmistrenko, S., Yakymenko, I.
Формат: Стаття
Мова:Англійська
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
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Цитувати:Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
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author Burlaka, A.
Tsybulin, O.
Sidorik, E.
Lukin, S.
Polishuk, V.
Tsehmistrenko, S.
Yakymenko, I.
author_facet Burlaka, A.
Tsybulin, O.
Sidorik, E.
Lukin, S.
Polishuk, V.
Tsehmistrenko, S.
Yakymenko, I.
citation_txt Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ.
collection DSpace DC
container_title Experimental Oncology
description Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
 significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
 under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead
 to oxidative stress in the cell. Materials and Methods: Embryos of Japanese quails were exposed in ovo to extremely low intensity
 RF-EMR of GSM 900 MHz (0.25 µW/cm2
 ) during 158–360 h discontinuously (48 c — ON, 12 c — OFF) before and in the
 initial stages of development. The levels of superoxide (O2·
 -
 ), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS),
 8-oxo-2’-deoxyguanosine (8-oxo-dG) and antioxidant enzymes’ activities were assessed in cells/tissues of 38-h, 5- and 10-day
 RF-EMR exposed and unexposed embryos. Results: The exposure resulted in a significant persistent overproduction of superoxide
 and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxodG
 followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo
 cells. Conclusion: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least
 one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage
 of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells
first_indexed 2025-12-07T20:48:17Z
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last_indexed 2025-12-07T20:48:17Z
publishDate 2013
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
record_format dspace
spelling Burlaka, A.
Tsybulin, O.
Sidorik, E.
Lukin, S.
Polishuk, V.
Tsehmistrenko, S.
Yakymenko, I.
2019-01-19T20:56:23Z
2019-01-19T20:56:23Z
2013
Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145241
Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
 significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
 under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead
 to oxidative stress in the cell. Materials and Methods: Embryos of Japanese quails were exposed in ovo to extremely low intensity
 RF-EMR of GSM 900 MHz (0.25 µW/cm2
 ) during 158–360 h discontinuously (48 c — ON, 12 c — OFF) before and in the
 initial stages of development. The levels of superoxide (O2·
 -
 ), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS),
 8-oxo-2’-deoxyguanosine (8-oxo-dG) and antioxidant enzymes’ activities were assessed in cells/tissues of 38-h, 5- and 10-day
 RF-EMR exposed and unexposed embryos. Results: The exposure resulted in a significant persistent overproduction of superoxide
 and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxodG
 followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo
 cells. Conclusion: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least
 one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage
 of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Original contributions
Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
Article
published earlier
spellingShingle Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
Burlaka, A.
Tsybulin, O.
Sidorik, E.
Lukin, S.
Polishuk, V.
Tsehmistrenko, S.
Yakymenko, I.
Original contributions
Original contributions
title Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
title_full Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
title_fullStr Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
title_full_unstemmed Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
title_short Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
title_sort overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
topic Original contributions
Original contributions
topic_facet Original contributions
Original contributions
url https://nasplib.isofts.kiev.ua/handle/123456789/145241
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AT lukins overproductionoffreeradicalspeciesinembryonalcellsexposedtolowintensityradiofrequencyradiation
AT polishukv overproductionoffreeradicalspeciesinembryonalcellsexposedtolowintensityradiofrequencyradiation
AT tsehmistrenkos overproductionoffreeradicalspeciesinembryonalcellsexposedtolowintensityradiofrequencyradiation
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