Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation
Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
 significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
 under RF-EMR exposure...
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| Published in: | Experimental Oncology |
|---|---|
| Date: | 2013 |
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145241 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862746940976922624 |
|---|---|
| author | Burlaka, A. Tsybulin, O. Sidorik, E. Lukin, S. Polishuk, V. Tsehmistrenko, S. Yakymenko, I. |
| author_facet | Burlaka, A. Tsybulin, O. Sidorik, E. Lukin, S. Polishuk, V. Tsehmistrenko, S. Yakymenko, I. |
| citation_txt | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead
to oxidative stress in the cell. Materials and Methods: Embryos of Japanese quails were exposed in ovo to extremely low intensity
RF-EMR of GSM 900 MHz (0.25 µW/cm2
) during 158–360 h discontinuously (48 c — ON, 12 c — OFF) before and in the
initial stages of development. The levels of superoxide (O2·
-
), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS),
8-oxo-2’-deoxyguanosine (8-oxo-dG) and antioxidant enzymes’ activities were assessed in cells/tissues of 38-h, 5- and 10-day
RF-EMR exposed and unexposed embryos. Results: The exposure resulted in a significant persistent overproduction of superoxide
and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxodG
followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo
cells. Conclusion: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least
one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage
of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells
|
| first_indexed | 2025-12-07T20:48:17Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145241 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:48:17Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Burlaka, A. Tsybulin, O. Sidorik, E. Lukin, S. Polishuk, V. Tsehmistrenko, S. Yakymenko, I. 2019-01-19T20:56:23Z 2019-01-19T20:56:23Z 2013 Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation / A. Burlaka, O. Tsybulin, E. Sidorik, S. Lukin, V. Polishuk, S. Tsehmistrenko, I. Yakymenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 219-225. — Бібліогр.: 60 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145241 Aim: Long-term exposure of humans to low intensity radiofrequency electromagnetic radiation (RF-EMR) leads to a statistically
 significant increase in tumor incidence. Mechanisms of such the effects are unclear, but features of oxidative stress in living cells
 under RF-EMR exposure were previously reported. Our study aims to assess a production of initial free radical species, which lead
 to oxidative stress in the cell. Materials and Methods: Embryos of Japanese quails were exposed in ovo to extremely low intensity
 RF-EMR of GSM 900 MHz (0.25 µW/cm2
 ) during 158–360 h discontinuously (48 c — ON, 12 c — OFF) before and in the
 initial stages of development. The levels of superoxide (O2·
 -
 ), nitrogen oxide (NO·), thiobarbituric acid reactive substances (TBARS),
 8-oxo-2’-deoxyguanosine (8-oxo-dG) and antioxidant enzymes’ activities were assessed in cells/tissues of 38-h, 5- and 10-day
 RF-EMR exposed and unexposed embryos. Results: The exposure resulted in a significant persistent overproduction of superoxide
 and nitrogen oxide in embryo cells during all period of analyses. As a result, significantly increased levels of TBARS and 8-oxodG
 followed by significantly decreased levels of superoxide dismutase and catalase activities were developed in the exposed embryo
 cells. Conclusion: Exposure of developing quail embryos to extremely low intensity RF-EMR of GSM 900 MHz during at least
 one hundred and fifty-eight hours leads to a significant overproduction of free radicals/reactive oxygen species and oxidative damage
 of DNA in embryo cells. These oxidative changes may lead to pathologies up to oncogenic transformation of cells en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Original contributions Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation Article published earlier |
| spellingShingle | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation Burlaka, A. Tsybulin, O. Sidorik, E. Lukin, S. Polishuk, V. Tsehmistrenko, S. Yakymenko, I. Original contributions Original contributions |
| title | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| title_full | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| title_fullStr | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| title_full_unstemmed | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| title_short | Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| title_sort | overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation |
| topic | Original contributions Original contributions |
| topic_facet | Original contributions Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145241 |
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