Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women

Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women

Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case...

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Published in:Experimental Oncology
Date:2013
Main Author: Kaur, S.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
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Short communications
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145242
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145242
record_format dspace
spelling Kaur, S.
2019-01-19T20:57:55Z
2019-01-19T20:57:55Z
2013
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145242
Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women. Materials and Methods: Polymorphism was determined by polymerase chain reaction — restriction fragment length polymorphism (PCR-RFLP) method and risk of cervical cancer was evaluated by calculating odds ratios (ORs) and 95% confidence interval (CI) using a multivariate logistic regression analysis. Results: No association was found between variant forms (AC, AA) of LIGI gene and risk of cervical cancer (OR — 0.8, 95% CI 0.46–1.53 and OR — 1.0, 95% CI 0.51–2.06, respectively). However, increased but statistically non-significant risk of adenocarcinoma was observed for cervical cancer patients having AC (OR — 4.6, 95% CI 0.62–33.82) and AA (OR — 5.0, 95% CI 0.63–39.58) genotypes. Conclusion: It can thus be concluded that there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women. Further investigations in larger studies need to be carried out for more analysis.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Short communications
Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
spellingShingle Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
Kaur, S.
Short communications
title_short Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
title_full Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
title_fullStr Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
title_full_unstemmed Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women
title_sort human dna ligase i (ligi) gene and risk of cervical cancer in north indian women
author Kaur, S.
author_facet Kaur, S.
topic Short communications
topic_facet Short communications
publishDate 2013
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: DNA repair genetic polymorphisms may affect cancer susceptibility as genetic variations in DNA repair genes may influence DNA repair capacity. In the present study, the association of polymorphic forms of DNA repair gene, DNA ligase I (LIGI) was examined with the risk of cervical cancer in case of North Indian women. Materials and Methods: Polymorphism was determined by polymerase chain reaction — restriction fragment length polymorphism (PCR-RFLP) method and risk of cervical cancer was evaluated by calculating odds ratios (ORs) and 95% confidence interval (CI) using a multivariate logistic regression analysis. Results: No association was found between variant forms (AC, AA) of LIGI gene and risk of cervical cancer (OR — 0.8, 95% CI 0.46–1.53 and OR — 1.0, 95% CI 0.51–2.06, respectively). However, increased but statistically non-significant risk of adenocarcinoma was observed for cervical cancer patients having AC (OR — 4.6, 95% CI 0.62–33.82) and AA (OR — 5.0, 95% CI 0.63–39.58) genotypes. Conclusion: It can thus be concluded that there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women. Further investigations in larger studies need to be carried out for more analysis.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145242
fulltext
citation_txt Human DNA ligase I (LIGI) gene and risk of cervical cancer in North Indian women / S. Kaur // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 226-228. — Бібліогр.: 21 назв. — англ.
work_keys_str_mv AT kaurs humandnaligaseiligigeneandriskofcervicalcancerinnorthindianwomen
first_indexed 2025-11-25T01:47:21Z
last_indexed 2025-11-25T01:47:21Z
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