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Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology

Aim: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with acute lymphoblastic leukemia (ALL) and in healthy subjects using biochip array technology. This approach allows multi-analytical determination from a single sample. Methods: A total of 15 ALL patients and 15 he...

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Veröffentlicht in:Experimental Oncology
Datum:2013
Hauptverfasser: Horacek, J.M., Kupsa, T., Vasatova, M., Jebavy, L., Zak, P.
Format: Artikel
Sprache:Englisch
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
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Short communications
Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/145243
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology / J.M. Horacek, T. Kupsa, M. Vasatova, L. Jebavy, P. Zak // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 229-230. — Бібліогр.: 19 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
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author Horacek, J.M.
Kupsa, T.
Vasatova, M.
Jebavy, L.
Zak, P.
author_facet Horacek, J.M.
Kupsa, T.
Vasatova, M.
Jebavy, L.
Zak, P.
citation_txt Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology / J.M. Horacek, T. Kupsa, M. Vasatova, L. Jebavy, P. Zak // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 229-230. — Бібліогр.: 19 назв. — англ.
collection DSpace DC
container_title Experimental Oncology
description Aim: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with acute lymphoblastic leukemia (ALL) and in healthy subjects using biochip array technology. This approach allows multi-analytical determination from a single sample. Methods: A total of 15 ALL patients and 15 healthy subjects (blood donors) were studied. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. T-tests were used for statistical analysis. Results: Comparing cytokine and adhesion molecule levels in ALL patients and in healthy subject, we found significant increase in serum VCAM-1 (p < 0.000001), ICAM-1 (p < 0.0001), L-selectin (p < 0.0001), IL-8 (p < 0.001), MCP-1 (p < 0.01), and significant decrease (p < 0.01) in serum IL-3 and IL-4. Conclusion: Our results indicate that serum levels of specific cytokines and adhesion molecules (VCAM-1, ICAM-1, L-selectin, IL-8, IL-3, IL-4, MCP-1) are significantly altered in patients with newly diagnosed ALL, reflecting acti­vity of the disease. Further investigation is needed to establish if these alterations could be used as a prognostic indicator for ALL.
first_indexed 2025-12-07T19:03:32Z
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language English
last_indexed 2025-12-07T19:03:32Z
publishDate 2013
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
record_format dspace
spelling Horacek, J.M.
Kupsa, T.
Vasatova, M.
Jebavy, L.
Zak, P.
2019-01-19T21:00:44Z
2019-01-19T21:00:44Z
2013
Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology / J.M. Horacek, T. Kupsa, M. Vasatova, L. Jebavy, P. Zak // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 229-230. — Бібліогр.: 19 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145243
Aim: Evaluation of serum levels of 17 cytokines and 5 adhesion molecules in patients with acute lymphoblastic leukemia (ALL) and in healthy subjects using biochip array technology. This approach allows multi-analytical determination from a single sample. Methods: A total of 15 ALL patients and 15 healthy subjects (blood donors) were studied. Serum samples were analyzed by biochip based immunoassays on the Evidence Investigator analyzer. T-tests were used for statistical analysis. Results: Comparing cytokine and adhesion molecule levels in ALL patients and in healthy subject, we found significant increase in serum VCAM-1 (p < 0.000001), ICAM-1 (p < 0.0001), L-selectin (p < 0.0001), IL-8 (p < 0.001), MCP-1 (p < 0.01), and significant decrease (p < 0.01) in serum IL-3 and IL-4. Conclusion: Our results indicate that serum levels of specific cytokines and adhesion molecules (VCAM-1, ICAM-1, L-selectin, IL-8, IL-3, IL-4, MCP-1) are significantly altered in patients with newly diagnosed ALL, reflecting acti­vity of the disease. Further investigation is needed to establish if these alterations could be used as a prognostic indicator for ALL.
The work was supported by a long-term organization
 development plan 1011 (Faculty of Military Health
 Sciences, Hradec Kralove) and by a specific research
 project “Analysis of defined prognostic factors in acute
 leukemia” (Faculty of Military Health Sciences, Hradec
 Kralove)
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Short communications
Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
Article
published earlier
spellingShingle Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
Horacek, J.M.
Kupsa, T.
Vasatova, M.
Jebavy, L.
Zak, P.
Short communications
title Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
title_full Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
title_fullStr Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
title_full_unstemmed Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
title_short Evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
title_sort evaluation of serum levels of multiple cytokines and adhesion molecules in patients with newly diagnosed acute lymphoblastic leukemia using biochip array technology
topic Short communications
topic_facet Short communications
url https://nasplib.isofts.kiev.ua/handle/123456789/145243
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AT kupsat evaluationofserumlevelsofmultiplecytokinesandadhesionmoleculesinpatientswithnewlydiagnosedacutelymphoblasticleukemiausingbiochiparraytechnology
AT vasatovam evaluationofserumlevelsofmultiplecytokinesandadhesionmoleculesinpatientswithnewlydiagnosedacutelymphoblasticleukemiausingbiochiparraytechnology
AT jebavyl evaluationofserumlevelsofmultiplecytokinesandadhesionmoleculesinpatientswithnewlydiagnosedacutelymphoblasticleukemiausingbiochiparraytechnology
AT zakp evaluationofserumlevelsofmultiplecytokinesandadhesionmoleculesinpatientswithnewlydiagnosedacutelymphoblasticleukemiausingbiochiparraytechnology

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