Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia

• Опубліковано в: : Experimental Oncology
• Дата: 2013
• Автори: Janisch, Yu.V., Artamonova, A.B., Shlyakhovenko, V.A.
• Формат: Стаття
• Мова: Англійська
• Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2013
• Теми: Original contributions
• Онлайн доступ: https://nasplib.isofts.kiev.ua/handle/123456789/145248
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Цитувати: Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia / Yu.V. Janisch, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 198-201. — Бібліогр.: 10 назв. — англ.

Aim: To increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC). Materials and Methods: The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats. Glycopeptide cancer vaccine prepared from P-388 leukemia cells, was immobilized of RC. ζ-potential of thymocytes from tumor-bearing mice was calculated from Smoluchowski equation. Results: The data have demonstrated the principal possibility of using the fragments of reconstructed chromatin of heterologous origin as a carrier of glycopeptide cancer vaccine prepared from the cells of P-388 leukemia. Preventive immunization with the correspondingly immobilized vaccine normalized ζ-potential of thymocytes in animals with transplanted P‑388 leukemia. Conclusions: The use of immobilization of glycopeptide cancer vaccine on reconstructed chromatin improves anticancer activity of the vaccination.