Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia
Aim: To increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC). Materials and Methods: The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats....
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| Published in: | Experimental Oncology |
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| Date: | 2013 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145248 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia / Yu.V. Janisch, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 198-201. — Бібліогр.: 10 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862748808719368192 |
|---|---|
| author | Janisch, Yu.V. Artamonova, A.B. Shlyakhovenko, V.A. |
| author_facet | Janisch, Yu.V. Artamonova, A.B. Shlyakhovenko, V.A. |
| citation_txt | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia / Yu.V. Janisch, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 198-201. — Бібліогр.: 10 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC). Materials and Methods: The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats. Glycopeptide cancer vaccine prepared from P-388 leukemia cells, was immobilized of RC. ζ-potential of thymocytes from tumor-bearing mice was calculated from Smoluchowski equation. Results: The data have demonstrated the principal possibility of using the fragments of reconstructed chromatin of heterologous origin as a carrier of glycopeptide cancer vaccine prepared from the cells of P-388 leukemia. Preventive immunization with the correspondingly immobilized vaccine normalized ζ-potential of thymocytes in animals with transplanted P‑388 leukemia. Conclusions: The use of immobilization of glycopeptide cancer vaccine on reconstructed chromatin improves anticancer activity of the vaccination.
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| first_indexed | 2025-12-07T20:56:55Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145248 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:56:55Z |
| publishDate | 2013 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Janisch, Yu.V. Artamonova, A.B. Shlyakhovenko, V.A. 2019-01-19T21:09:53Z 2019-01-19T21:09:53Z 2013 Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia / Yu.V. Janisch, A.B. Artamonova, V.A. Shlyakhovenko // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 198-201. — Бібліогр.: 10 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145248 Aim: To increase the effectiveness of anticancer vaccine delivery and activity via its immobilization on reconstructed chromatin (RC). Materials and Methods: The hybrid mice of CDF-1 line with transplanted P-388 leukemia were used. Reconstructed chromatin was obtained from the thymus of inbred rats. Glycopeptide cancer vaccine prepared from P-388 leukemia cells, was immobilized of RC. ζ-potential of thymocytes from tumor-bearing mice was calculated from Smoluchowski equation. Results: The data have demonstrated the principal possibility of using the fragments of reconstructed chromatin of heterologous origin as a carrier of glycopeptide cancer vaccine prepared from the cells of P-388 leukemia. Preventive immunization with the correspondingly immobilized vaccine normalized ζ-potential of thymocytes in animals with transplanted P‑388 leukemia. Conclusions: The use of immobilization of glycopeptide cancer vaccine on reconstructed chromatin improves anticancer activity of the vaccination. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia Article published earlier |
| spellingShingle | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia Janisch, Yu.V. Artamonova, A.B. Shlyakhovenko, V.A. Original contributions |
| title | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| title_full | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| title_fullStr | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| title_full_unstemmed | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| title_short | Glycopeptide vaccine on DNA-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| title_sort | glycopeptide vaccine on dna-histone carrier and its impact on ζ-potential of effector cells during experimental treatment of lymphoblastic leukemia |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145248 |
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