Effects of alvocidib and carboplatin on ovarian cancer cells in vitro
Aim: Failure of platinum chemotherapy is an unresolved issue in ovarian cancer. Targeted therapy has been added to the treatment options in solid cancers. Alvocidib is a cyclin dependent kinase inhibitor. Materials and methods: This study evaluated the effects of alvocidib together with carboplatin...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2013 |
| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145250 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effects of alvocidib and carboplatin on ovarian cancer cells in vitro / K. H. Baumann, H. Kim, J. Rinke, T. Plaum, U. Wagner, S. Reinartz // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 168-173. — Бібліогр.: 40 назв. — англ. |
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Baumann, K.H. Kim, H. Rinke, J. Plaum, T. Wagner, U. Reinartz, S. 2019-01-19T21:11:37Z 2019-01-19T21:11:37Z 2013 Effects of alvocidib and carboplatin on ovarian cancer cells in vitro / K. H. Baumann, H. Kim, J. Rinke, T. Plaum, U. Wagner, S. Reinartz // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 168-173. — Бібліогр.: 40 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145250 Aim: Failure of platinum chemotherapy is an unresolved issue in ovarian cancer. Targeted therapy has been added to the treatment options in solid cancers. Alvocidib is a cyclin dependent kinase inhibitor. Materials and methods: This study evaluated the effects of alvocidib together with carboplatin on ovarian cancer cells (BG-1 and Skov-3) in vitro applying proliferation assays, cell cycle distribution analyses, apoptosis induction assays, and drug accumulation assay. Results: Proliferation of both cell lines was inhibited by carboplatin and alvocidib. The interaction index revealed drug synergism at distinct drug concentrations. Cell cycle distribution was altered. Alvocidib induced apoptosis in Skov-3 cells, and necrosis in BG-1 cells. Rhodamine accumulation was increased by alvocidib or both compounds together. Conclusion: These data provide evidence for antiproliferative effects of alvocidib on human ovarian cancer cells in vitro associated with changes in cell cycle distribution, the induction of apoptosis, and modulation of intracellular drug accumulation. Alvocidib and carboplatin showed some cooperative activity. Alvocidib was kindly provided by “Sanofi”, Frankfurt, Germany. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Effects of alvocidib and carboplatin on ovarian cancer cells in vitro Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| spellingShingle |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro Baumann, K.H. Kim, H. Rinke, J. Plaum, T. Wagner, U. Reinartz, S. Original contributions |
| title_short |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| title_full |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| title_fullStr |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| title_full_unstemmed |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| title_sort |
effects of alvocidib and carboplatin on ovarian cancer cells in vitro |
| author |
Baumann, K.H. Kim, H. Rinke, J. Plaum, T. Wagner, U. Reinartz, S. |
| author_facet |
Baumann, K.H. Kim, H. Rinke, J. Plaum, T. Wagner, U. Reinartz, S. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2013 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: Failure of platinum chemotherapy is an unresolved issue in ovarian cancer. Targeted therapy has been added to the treatment options in solid cancers. Alvocidib is a cyclin dependent kinase inhibitor. Materials and methods: This study evaluated the effects of alvocidib together with carboplatin on ovarian cancer cells (BG-1 and Skov-3) in vitro applying proliferation assays, cell cycle distribution analyses, apoptosis induction assays, and drug accumulation assay. Results: Proliferation of both cell lines was inhibited by carboplatin and alvocidib. The interaction index revealed drug synergism at distinct drug concentrations. Cell cycle distribution was altered. Alvocidib induced apoptosis in Skov-3 cells, and necrosis in BG-1 cells. Rhodamine accumulation was increased by alvocidib or both compounds together. Conclusion: These data provide evidence for antiproliferative effects of alvocidib on human ovarian cancer cells in vitro associated with changes in cell cycle distribution, the induction of apoptosis, and modulation of intracellular drug accumulation. Alvocidib and carboplatin showed some cooperative activity.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145250 |
| fulltext |
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| citation_txt |
Effects of alvocidib and carboplatin on ovarian cancer cells in vitro / K. H. Baumann, H. Kim, J. Rinke, T. Plaum, U. Wagner, S. Reinartz // Experimental Oncology. — 2013. — Т. 35, № 3. — С. 168-173. — Бібліогр.: 40 назв. — англ. |
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2025-11-24T23:51:52Z |
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2025-11-24T23:51:52Z |
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