Markers of epithelial-mesenchymal transition in renal cell carcinoma
Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2013 |
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| Format: | Artikel |
| Sprache: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2013
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| Zitieren: | Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
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Dumanskiy, Y.V. Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Chystiakov, R.S. 2019-01-20T09:05:57Z 2019-01-20T09:05:57Z 2013 Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145287 Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Arrticles not related to special issue topics Markers of epithelial-mesenchymal transition in renal cell carcinoma Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Markers of epithelial-mesenchymal transition in renal cell carcinoma |
| spellingShingle |
Markers of epithelial-mesenchymal transition in renal cell carcinoma Dumanskiy, Y.V. Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Chystiakov, R.S. Arrticles not related to special issue topics |
| title_short |
Markers of epithelial-mesenchymal transition in renal cell carcinoma |
| title_full |
Markers of epithelial-mesenchymal transition in renal cell carcinoma |
| title_fullStr |
Markers of epithelial-mesenchymal transition in renal cell carcinoma |
| title_full_unstemmed |
Markers of epithelial-mesenchymal transition in renal cell carcinoma |
| title_sort |
markers of epithelial-mesenchymal transition in renal cell carcinoma |
| author |
Dumanskiy, Y.V. Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Chystiakov, R.S. |
| author_facet |
Dumanskiy, Y.V. Kudriashov, A.G. Vasilenko, I.V. Kondratyuk, R.B. Gulkov, Y.K. Chystiakov, R.S. |
| topic |
Arrticles not related to special issue topics |
| topic_facet |
Arrticles not related to special issue topics |
| publishDate |
2013 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim - to study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis. The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3 - 6 months) and a long-term survival group (17 - 24 months). EMT markers expression was assessed by immunohistochemical methods. It was determined that the rate of spindle-cell EMT was 96,4 % in a short-term survival group and 42,1 % in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3 - 4 occurred in 100 % of cases in a short-term survival group versus 68,4 % in a longterm survival group. Conclusion: the rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia. Key Words: renal cell carcinoma, epithelial-mesenchymal transition, the degree of Furhman’s nuclear atypia.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145287 |
| fulltext |
|
| citation_txt |
Markers of epithelial-mesenchymal transition in renal cell carcinoma / Y.V. Dumanskiy, A.G. Kudriashov, I.V. Vasilenko, R.B. Kondratyuk, Y.K. Gulkov, R.S. Сhystiakov // Experimental Oncology. — 2013. — Т. 35, № 4. — С. 325-327. — Бібліогр.: 14 назв. — англ. |
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2025-11-26T22:57:32Z |
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2025-11-26T22:57:32Z |
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