Study of trace elements status of breast cancer patients
The
 last 15 
 years, the methods of evaluation of trace elements in the human body 
 for the hair analysis have been actively developing. The content of trace elements 
 in hair reflects their level in the human body, and is an integral indicator charac
 -&am...
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| Опубліковано в: : | Онкологія |
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| Дата: | 2017 |
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2017
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Study of trace elements status of breast cancer patients / M.N. Tillashaykhov, A.T. Khudaykulov, E.A. Danilova, A.A. Usupbekov, L.T. Alimkhodjaeva // Онкологія. — 2017. — Т. 19, № 1. — С. 25-28. — Бібліогр.: 25 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1860204934310395904 |
|---|---|
| author | Tillashaykhov, M.N Khudaykulov, A.T. Danilova, E.A. Usupbekov, A.A. Alimkhodjaeva, L.T. |
| author_facet | Tillashaykhov, M.N Khudaykulov, A.T. Danilova, E.A. Usupbekov, A.A. Alimkhodjaeva, L.T. |
| citation_txt | Study of trace elements status of breast cancer patients / M.N. Tillashaykhov, A.T. Khudaykulov, E.A. Danilova, A.A. Usupbekov, L.T. Alimkhodjaeva // Онкологія. — 2017. — Т. 19, № 1. — С. 25-28. — Бібліогр.: 25 назв. — англ. |
| collection | DSpace DC |
| container_title | Онкологія |
| description | The
last 15 
years, the methods of evaluation of trace elements in the human body 
for the hair analysis have been actively developing. The content of trace elements 
in hair reflects their level in the human body, and is an integral indicator charac
-
terizing his element status. 
Purpose: 
study of trace elements in patients with second-
stage breast cancer. 
Object and Methods: 
to determine the content of trace elements, 
it was stu 
died the hair of 30 
patients with stage II breast cancer who were treated at 
the Natio 
nal Cancer Research Center of the Ministry of Health of the Republic of 
Uzbekistan in 2016. The study of hair samples for content of trace elements (calci
-
um, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, chromium, 
selenium, iodine, bromine) was conducted in the laboratory analysis of the activa
-
tion of the Institute of Nuclear Physics of Uzbekistan Academy of Sciences, instru
-
mental neutron activation analysis. The received data on the micronutrient content 
in hair of patients compared with reference values for the population of Uzbekistan, 
adopted at the Institute of Nuclear Physics. 
Results: 
the reduction of iron, zinc, cop
-
per, cobalt level and high content of chlorine as compared with the reference val
-
ues were showed. 
Conclusions: 
undertaken
studies have shown the possibility of us
-
ing of the results for the primary prevention and identification of risk groups among 
women, as well as the usefulness of the correction of specialized treatment medica
-
tion with microelement complexes.
Резюме. 
Последние 15 
лет активно развиваются ме
-
тодики оценки содержания микроэлементов (МЭ) 
в организме человека по анализу волос. Содержание 
МЭ в 
волосах рассматривают в настоящее время 
как интегральный показатель, характеризующий 
элементный статус организма. 
Цель работы:
изуче
-
ние содержания МЭ у больных раком молочной желе
-
зы (РМЖ) II стадии. 
Объект и 
методы:
исследованы 
волосы 30 
пациенток с РМЖ II стадии, находивших
-
ся на стационарном лечении в Республиканском онко
-
логическом научном центре Министерства здраво
-
охранения Республики Узбекистан в 2016 
г. Изучение 
образцов волос на содержание МЭ (кальций, калий, 
натрий, хлор, железо, цинк, медь, марганец, кобальт, 
хром, селен, йод, бром) проводили в лаборатории акти
-
вационного анализа Института ядерной физики Ака
-
демии наук Республики Узбекистан инструменталь
-
ным нейтронно-активационным анализом. Получен
-
ные данные о содержании МЭ в волосах пациенток 
сравнивали с 
референтными показателями для насе
-
ления Узбекистана, принятыми в Институте. 
Ре
-
зультаты:
выявлено сниженное содержание железа, 
цинка, меди, кобальта, и 
повышенное хлора по 
срав
-
нению с референтными значениями. 
Выводы:
прове
-
денные исследования указывают на возможность ис
-
пользования данных о содержании МЭ в волосах для 
первичной профилактики РМЖ и выявления групп ри
-
ска среди женщин, а также свидетельствуют о це
-
лесообразности проведения коррекции специализи
-
рованного лечения медикаментозными комплексами 
с добавлением МЭ.
|
| first_indexed | 2025-12-07T18:12:11Z |
| format | Article |
| fulltext |
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
25ОНКОЛОГИЯ • Т. 19 • № 1 • 2017 25
INTRODUCTION
Breast cancer (BC) is a multifactorial disease. Envi
ronmental factors such as radiation, viruses and chemi
cals have an important role as carcinogenic agents. At
the same time, numerous secondary factors: gender, age,
economic development of the country of residence, later
first birth (40 years and older), the presence of blood rela
tives diagnosed with BC, ionizing radiation to the chest
area, early menarche (under 12 years old), late meno
pause (after 55 years), breastfeeding, increased body
weight in post menopause, sedentary lifestyle, use of oral
contraceptives, hormone replacement therapy and dense
breast tissue also have a significant effect on the occur
rence and the development of breast tumors [1].
Until recently, the main focus of cancer research has been
directed at identifying natural or manmade carcinogens. Pri
marily, to the prevention of cancer came, as a problem remo
ving the newly discovered carcinogens from the environment
or minimize the impact of these agents on humans.
Although some progress has been achieved on the ba
sis of this approach, however, it became increasingly ap
parent that the complete removal of all cancercausing
agents in the environment is impossible. Furthermore,
there is a possibility that some malignant tumors develop
under the influence of endogenous carcinogenic agents.
Currently, health care workers involved in the preven
tion of cancer in North America and Europe, pay more
and more attention to the ways and means by which the
body’s resistance could be strengthened sufficiently to re
sist the effects of carcinogens and other factors, which all
people naturally are subject to a greater or lesser extent.
When there are high expectations in the alimentary
cancer prevention, because it can be the easiest and most
effective way. This area of cancer research is new, where
trace ele ments play an important role. Excess or deficien
cy in the body of certain chemical elements or their com
pounds often leads to pathological conditions [2]. Current
ly, it is known the relationship between chemical composi
tion of biological substrates and concrete manifestations of
the pathologi cal process, for example for cancer of the gas
trointestinal tract [3]. In the development of tumor process
microelements play a dual role — on the one hand, they ac
tively accumulate tumor cells, promoting their proliferation,
on the other hand, they are capable of potentiating the an
titumor immunity [4, 5]. The role of trace elements in the
process of regeneration and differentiation, apoptosis in the
pathogenesis of tumor proved literature data [6]. It should
be stressed their importance in the regulation of the activi
ty of oxidative stress as one of the pathogenic mechanisms
of initiation and support of tumor growth in humans [2].
The last 15 years, the methods of evaluation of trace el
ements in the human body for the hair analysis has been
actively developed. The content of trace elements in hair
reflects their level in the human body, and it is an integral
indicator characterizing his element status [7]. The hair is
most informative biological substrate as compared to others
(blood, urine, saliva, lacrimal fluid, etc.), it is simple and
fence materials, noninvasive, has longterm storage abili
ty and the higher information content of microelements.
Trace element analysis of human hair makes it pos
sible to assess state of the environment (housing, water,
food and so on), that allows carrying out sanitaryepi
demiological and preventive measures.
As a result of studying the microelement status it is pos
sible to early prediction of cancer risk in the population, es
pecially in areas with unfavorable ecological situation and
the presence of large industrial enterprises with hazar dous
STUDY OF TRACE ELEMENTS STATUS
OF BREAST CANCER PATIENTS
The last 15 years, the methods of evaluation of trace elements in the human body
for the hair analysis have been actively developing. The content of trace elements
in hair reflects their level in the human body, and is an integral indicator charac-
terizing his element status. Purpose: study of trace elements in patients with second-
stage breast cancer. Object and Methods: to determine the content of trace elements,
it was stu died the hair of 30 patients with stage II breast cancer who were treated at
the Natio nal Cancer Research Center of the Ministry of Health of the Republic of
Uzbekistan in 2016. The study of hair samples for content of trace elements (calci-
um, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, chromium,
selenium, iodine, bromine) was conducted in the laboratory analysis of the activa-
tion of the Institute of Nuclear Physics of Uzbekistan Academy of Sciences, instru-
mental neutron activation analysis. The received data on the micronutrient content
in hair of patients compared with reference values for the population of Uzbekistan,
adopted at the Institute of Nuclear Physics. Results: the reduction of iron, zinc, cop-
per, cobalt level and high content of chlorine as compared with the reference val-
ues were showed. Conclusions: undertaken studies have shown the possibility of us-
ing of the results for the primary prevention and identification of risk groups among
women, as well as the usefulness of the correction of specialized treatment medica-
tion with microelement complexes.
M.N. Tillashaykhov1
A.T. Khudaykulov1
E.A. Danilova2
A.A. Usupbekov1
L.T. Alimkhodjaeva1
1National Cancer Research
Center of the Ministry of Health
of the Republic of Uzbekistan
2Institute of Nuclear Physics,
Academy of Sciences
of Uzbekistan, Tashkent,
Republic of Uzbekistan
Key Words: breast cancer, trace
elements, hair, neutron activation
analysis.
ОНКОЛОГИЯ • Т. 19 • № 1 • 2017
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
26
production conditions [4, 8, 9]. The hair compared with
other biological substrates accumulates the processes ha
ving longterm place in the human body under the influ
ence of complex of ecological and physiological factors,
so the analysis of the elemental composition can serve as a
means of diagnosis and a test to determine predisposition
to certain diseases, and also allows to find out the possible
causes of inefficient treatment [10, 11].
However, so far in the literature there are only a few frag
mentary reports of the multivariate analysis and the content
of trace elements in the hair of patients with such common
oncological disease as BC [12–14].
The purpose of research is the study of trace elements
in the hair of patients with stage II BC.
MATERIALS AND METHODS
To determine the content of trace elements it has been
stu died the hair of 30 women with stage II BC treated at
the National Cancer Research Center of the Ministry
of Health of the Republic of Uzbekistan in 2016. In the
study, the ethical principles of the World Medical Asso
ciation Declaration of Helsinki (1964, 2000) were met.
A voluntary consent to perform microelement ana lysis
of hair was received from every woman.
The average age of the patients was 50 ± 2,9 years. The
disease was confirmed by carrying out clinical, ultrasound,
mammography, cytological and histological studies. Bio
chemical studies were carried out (coagulogram, the study
of blood glucose, bilirubin, total protein). The study of hair
samples on the content of trace elements (calcium, potas
sium, sodium, chlorine, iron, zinc, copper, manganese,
cobalt, chromium, selenium, iodine, bromine) was con
ducted in the laboratory activation analysis of the Insti
tute of Nuclear Physics, Academy of Sciences of Uzbeki
stan tool neutron activation analysis. Methods of prepa
ring and carrying out the instrumental neutron activation
analysis are described in detail in [15, 16].
The data given by various authors of the normal range
of the content of most of the trace elements in the hair are
variable, because different regions are at different le vels of
anthropogenic load, so the elemental composition of hair
of people in each region has its own peculiarity. The con
centration of micronutrients in hair composition may vary
depending on the race, health condition, diet and hair co
lor [10]. 95% confidence interval (CI) [17] of the received
data on the micronutrient content of the in hair of patients
compared with reference values for the population of Uz
bekistan, received at the Institute of Nuclear Physics, Aca
demy of Sciences of Uzbekistan (Tashkent). Statistical ana
lysis of the results was carried out using MS Excel 2010 and
Statistica v. 6 program.
RESULTS AND DISCUSSION
An analysis of the elemental composition of hair clear
ly demonstrates the presence of imbalance in patients with
stage II BC. There is a decrease in the content of iron, zinc,
copper, cobalt and to high contents of chlorine. Compa
rison of the content of trace elements in the hair of patients
with BC with normal ranges of contents is shown in Table.
CI of the concentration of calcium, potassium and
sodium in the hair of BC patients was within the refer
ence values. Calcium has a direct impact on the energy
ba lance of the body. Changes in rates of cellular transport
of adenosine triphosphate dependent on calcium concen
tration, which may occur in the cells of a malignant tu
mor [18]. The test results show that the lower bound of
CI of chlorine in hair from patients with BC was 51.4%
above the upper limit of reference values (3028.0 µg/g).
Considering the physiological role of sodium, po
tassium and chlorine it should be noted that these ele
ments are the building blocks of all cells and tissues. In
the body, they are in a certain ratio to provide a constant
internal environment. Sodium and potassium chlorides
and strong electrolytes are involved in the generation and
conducting electrical pulses and nerve. An excess of po
tassium and sodium ions causes a change and distur
bance of homeostasis of metabolic processes in the body.
The incidence of excess and deficiency of trace ele
ments in the hair of patients with BC relative to the upper
and lower reference indicators are presented in Figure.
In determining the copper content in hair of patients
with BC it has been proved that the upper bound of CI
concentration of this bioelement was 54.0% less compared
to the lower limit of reference values (9.2 µg/g). Copper is
present in many enzymes (tyrosinase, ceruloplasmin, ami
noxidases, cytochrome oxidase), involved in the oxidation.
Table
The content of microelements in the hair of patients with BC, µg/g
Element
Patients with BC (n = 30) Reference range
М ± m 95% CI
Lower limit Upper limit Lower limit Upper limit
Calcium 1100.0 ± 280.0 551.2 1648.8 1500.0 2500.0
Potassium 1700.0 ± 220.0 1268.8 2131.2 1000.0 1500.0
Sodium 1700.0 ± 440.0 837.6 2562.4 500.0 900.0
Chlorine 4400.0 ± 700.0 3028.0 5772.0 1000.0 2000.0
Iron 19.0 ± 1.3 16.4 21.5 25.0 40.0
Zinc 110.0 ± 13.0 84.5 135.5 150.0 250.0
Copper 7.5 ± 0.9 5.7 9.2 20.0 35.0
Manganese 0.51 ± 0.04 0.43 0.58 0.40 1.00
Cobalt 0.04 ± 0.01 0.025 0.054 0.07 0.12
Chrome 0.32 ± 0.16 0.006 0.633 0.40 1.00
Selenium 0.38 ± 0.04 0.305 0.454 0.40 1.00
Iodine 6.60 ± 2.80 1.1 12.1 1.00 2.00
Bromine 2.30 ± 0.31 1.69 2.9 1.50 3.50
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
27ОНКОЛОГИЯ • Т. 19 • № 1 • 2017 27
Introduction of copper salts also protects the li ver from
the damaging effects of a number of carcinogens. How
ever, the copper has a seleniumanta gonistic property of
selenium deficiency symptoms were obtained in animals
treated with high doses of copper. At deficiency of copper
under the influence of dime thyl hydrazine in rats there is
a high incidence of renal tumors compared to ani mals that
received additional do ses of copper [19].
When assessing the content of microelements disco
vered that patients with BC upper bound CI iron con
centration was 14.0% lower than the lower limit of nor
mal values (32.2 µg/g). Iron plays an important role in
the processes of energy generation, in enzymatic reac
tions in achieving immune functions. Iron deficiency
leads to dysfunction of the major systems of the body:
bloodforming, nervous, immune and adaptation. High
concentrations of copper and iron were observed in the
liver and spleen in patients with cancer of the respiratory
tract, the genitourinary system, and breast. In the tissues
of malignant tumors of the esophagus, bronchi, gastro
intestinal tract and mammary gland are often increased
copper content than in the tissues of benign tumors [20].
The upper boundary of CI the content of zinc in hair
of patients with BC was 9.7% below lower limit of refe
rence values (135.5 µg/g). Zinc is an enzyme cofactor of
about 80 enzymes and is necessary for growth, develop
ment, reproduction, wound healing and other important
physiological functions. In those countries, where the food
is rich in zinc, cancer mortality is higher than in countries
where the national diet zinc content is less. Zinc ions ex
ist primarily in the form of complexes with proteins and
nucleic acids and participate in all aspects of intermedi
ary metabolism, transmission and regulation of the ex
pression of genetic information, storage, synthesis and
action of peptide hormones and structural maintenance
of chromatin and biological membranes. Zinc plays a key
role in the synthesis of proteins and nucleic acids. It is in
volved in the mechanisms associated with the processes of
regu lation of gene expression. Zinc deficiency is primari
ly associated with dysfunction of the immune system [21].
The upper bound of CI cobalt concentration in hair of
patients with BC was 28.6% lower than the lower limit of
the reference values (0.05 µg/g). Decreasing the amount of
trace elements in the hair of patients with BC in our view
can be explained by the intensive use of its tumor cells,
since, according to the A.P. Avtsyn (1991), cobalt has a
stimulating effect on cell proliferation to background tis
sue hypoxia, which is characteristic for tumors [2]. In pa
tients with BC the CI of the content of chromium in hair
was within the reference rates.
According to some authors [20, 22], the imbalance
of the chemical elements is the basis of the initiation
and promotion of cancer pathology, not only through
the modulation of metabolism and repair of nuclear
and mitochondrial DNA, but also a variety of enzyma
tic and protein molecules including lysosomal appara
tus, immune cells and the activity of antioxidant system.
On the other hand, chromium in concentrations causes
cell death through activation of apoptotic processes [2].
When determining the content of selenium in the hair
of patients with BC it was found that the upper bound
of CI concentrations of this microelements was at a le
vel lower limit reference value (0.45 µg/g).
Given the anticarcinogenic effect of selenium [7] it
may be assumed that low levels of the trace element is a
risk factor, because the microcell is required to maintain
a steady state of cell membranes, suppression of metabo
lic activation of procarcinogens in a cell, stimulation of
reparative DNA synthesis damaged carcinogen, as well
as maintain a high antioxidant potential [11].
Multielement analysis of hair of patients with BC
showed that the CI content of iodine is in the range of refe
rence values. Iodine — an essential element for the synthe
sis of thyroid hormones. The action of iodine on the syn
thesis of these hormones is dependent on the dose. The
basis of the effect of increasing doses hormonogenesis on
the principle of the twophase excess iodine — iodine or
ganification increase, and when it reaches a certain crit
ical concentration — unit organification. High doses of
iodine inhibits the absorption of iodide, it organification,
synthesis and secretion of thyroid hormones, glucose up
take and aminoacids [23, 24]. K.L. Streicher et al. (2004)
showed that the level of activity of selenium and selenium
thireoredoxin reductase regulate angiogenesis effect on en
dothelial growth factor in the breast tumor. In general, a
normal iodine balance is closely related with the concen
tration of selenium and breast diseases [25].
CI of concentrations of manganese and bromine in the
hair of patients with BC were in the range of normal values.
Thus, these results indicate that one of important
mecha nisms of the pathogenesis of BC is the presence of
trace elements imbalance in the body of patients. We can
assume that in the trace element composition of hair in pa
tients with BC affects developing malignant tumor process
associated with the redistribution trace element the pool due
to intensive use of them in the metabolism of tumor cells.
CONCLUSIONS
1. Analysis of elements content in hair of patients
with BC revealed their trace element status. A reduction
of calcium, iron, zinc, copper, cobalt, chromium, sele
nium rates, and an increase of potassium, sodium, chlo
rine, and iodine rates were ascertained.
Figure. The incidence of excess and deficiency of trace ele
ments in the hair of patients with BC relative to the upper and
lower reference rates
ОНКОЛОГИЯ • Т. 19 • № 1 • 2017
ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ
28
2. Studies have shown the possibility of using the re
sults for the primary prevention and identification of risk
groups among women, as well as the usefulness of the cor
rection of specialized treatment medication complexes
with trace elements.
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ИЗУЧЕНИЕ МИКРОЭЛЕМЕНТНОГО
СТАТУСА БОЛЬНЫХ РАКОМ МОЛОЧНОЙ
ЖЕЛЕЗЫ
М.Н. Тиллашайхов, А.Т. Худайкулов,
Е.А. Данилова, А.А. Юсупбеков,
Л.Т. Алимходжаева
Резюме. Последние 15 лет активно развиваются ме-
тодики оценки содержания микроэлементов (МЭ)
в организме человека по анализу волос. Содержание
МЭ в волосах рассматривают в настоящее время
как интегральный показатель, характеризующий
элементный статус организма. Цель работы: изуче-
ние содержания МЭ у больных раком молочной желе-
зы (РМЖ) II стадии. Объект и методы: исследованы
волосы 30 пациенток с РМЖ II стадии, находивших-
ся на стационарном лечении в Республиканском онко-
логическом научном центре Министерства здраво-
охранения Республики Узбекистан в 2016 г. Изучение
образцов волос на содержание МЭ (кальций, калий,
натрий, хлор, железо, цинк, медь, марганец, кобальт,
хром, селен, йод, бром) проводили в лаборатории акти-
вационного анализа Института ядерной физики Ака-
демии наук Республики Узбекистан инструменталь-
ным нейтронно-активационным анализом. Получен-
ные данные о содержании МЭ в волосах пациенток
сравнивали с референтными показателями для насе-
ления Узбекистана, принятыми в Институте. Ре-
зультаты: выявлено сниженное содержание железа,
цинка, меди, кобальта, и повышенное хлора по срав-
нению с референтными значениями. Выводы: прове-
денные исследования указывают на возможность ис-
пользования данных о содержании МЭ в волосах для
первичной профилактики РМЖ и выявления групп ри-
ска среди женщин, а также свидетельствуют о це-
лесообразности проведения коррекции специализи-
рованного лечения медикаментозными комплексами
с добавлением МЭ.
Ключевые слова: рак молочной железы,
микроэлементы, волосы, нейтронно
активационный анализ.
Correspondence:
Tillashaykhov M.N.
383, Faroby str., Tashkent 100174, Republic of Uzbekistan
National Cancer Research Center of the Ministry
of Health of the Republic of Uzbekistan
Email: dr.tilla@yandex.ru.
Submitted: December 12, 2016
|
| id | nasplib_isofts_kiev_ua-123456789-145294 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1562-1774 |
| language | English |
| last_indexed | 2025-12-07T18:12:11Z |
| publishDate | 2017 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Tillashaykhov, M.N Khudaykulov, A.T. Danilova, E.A. Usupbekov, A.A. Alimkhodjaeva, L.T. 2019-01-20T09:18:32Z 2019-01-20T09:18:32Z 2017 Study of trace elements status of breast cancer patients / M.N. Tillashaykhov, A.T. Khudaykulov, E.A. Danilova, A.A. Usupbekov, L.T. Alimkhodjaeva // Онкологія. — 2017. — Т. 19, № 1. — С. 25-28. — Бібліогр.: 25 назв. — англ. 1562-1774 https://nasplib.isofts.kiev.ua/handle/123456789/145294 The
 last 15 
 years, the methods of evaluation of trace elements in the human body 
 for the hair analysis have been actively developing. The content of trace elements 
 in hair reflects their level in the human body, and is an integral indicator charac
 -
 terizing his element status. 
 Purpose: 
 study of trace elements in patients with second-
 stage breast cancer. 
 Object and Methods: 
 to determine the content of trace elements, 
 it was stu 
 died the hair of 30 
 patients with stage II breast cancer who were treated at 
 the Natio 
 nal Cancer Research Center of the Ministry of Health of the Republic of 
 Uzbekistan in 2016. The study of hair samples for content of trace elements (calci
 -
 um, potassium, sodium, chlorine, iron, zinc, copper, manganese, cobalt, chromium, 
 selenium, iodine, bromine) was conducted in the laboratory analysis of the activa
 -
 tion of the Institute of Nuclear Physics of Uzbekistan Academy of Sciences, instru
 -
 mental neutron activation analysis. The received data on the micronutrient content 
 in hair of patients compared with reference values for the population of Uzbekistan, 
 adopted at the Institute of Nuclear Physics. 
 Results: 
 the reduction of iron, zinc, cop
 -
 per, cobalt level and high content of chlorine as compared with the reference val
 -
 ues were showed. 
 Conclusions: 
 undertaken
 studies have shown the possibility of us
 -
 ing of the results for the primary prevention and identification of risk groups among 
 women, as well as the usefulness of the correction of specialized treatment medica
 -
 tion with microelement complexes. Резюме. 
 Последние 15 
 лет активно развиваются ме
 -
 тодики оценки содержания микроэлементов (МЭ) 
 в организме человека по анализу волос. Содержание 
 МЭ в 
 волосах рассматривают в настоящее время 
 как интегральный показатель, характеризующий 
 элементный статус организма. 
 Цель работы:
 изуче
 -
 ние содержания МЭ у больных раком молочной желе
 -
 зы (РМЖ) II стадии. 
 Объект и 
 методы:
 исследованы 
 волосы 30 
 пациенток с РМЖ II стадии, находивших
 -
 ся на стационарном лечении в Республиканском онко
 -
 логическом научном центре Министерства здраво
 -
 охранения Республики Узбекистан в 2016 
 г. Изучение 
 образцов волос на содержание МЭ (кальций, калий, 
 натрий, хлор, железо, цинк, медь, марганец, кобальт, 
 хром, селен, йод, бром) проводили в лаборатории акти
 -
 вационного анализа Института ядерной физики Ака
 -
 демии наук Республики Узбекистан инструменталь
 -
 ным нейтронно-активационным анализом. Получен
 -
 ные данные о содержании МЭ в волосах пациенток 
 сравнивали с 
 референтными показателями для насе
 -
 ления Узбекистана, принятыми в Институте. 
 Ре
 -
 зультаты:
 выявлено сниженное содержание железа, 
 цинка, меди, кобальта, и 
 повышенное хлора по 
 срав
 -
 нению с референтными значениями. 
 Выводы:
 прове
 -
 денные исследования указывают на возможность ис
 -
 пользования данных о содержании МЭ в волосах для 
 первичной профилактики РМЖ и выявления групп ри
 -
 ска среди женщин, а также свидетельствуют о це
 -
 лесообразности проведения коррекции специализи
 -
 рованного лечения медикаментозными комплексами 
 с добавлением МЭ. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Онкологія Оригинальные исследования Study of trace elements status of breast cancer patients Изучение микроэлементного статуса больных раком молочной железы Article published earlier |
| spellingShingle | Study of trace elements status of breast cancer patients Tillashaykhov, M.N Khudaykulov, A.T. Danilova, E.A. Usupbekov, A.A. Alimkhodjaeva, L.T. Оригинальные исследования |
| title | Study of trace elements status of breast cancer patients |
| title_alt | Изучение микроэлементного статуса больных раком молочной железы |
| title_full | Study of trace elements status of breast cancer patients |
| title_fullStr | Study of trace elements status of breast cancer patients |
| title_full_unstemmed | Study of trace elements status of breast cancer patients |
| title_short | Study of trace elements status of breast cancer patients |
| title_sort | study of trace elements status of breast cancer patients |
| topic | Оригинальные исследования |
| topic_facet | Оригинальные исследования |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145294 |
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