Number of Langerhans cells is decreased in premalignant keratosis and skin cancers
Background: It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. Aim: To count Langerhans cells,...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2014 |
| Автори: | , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145317 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers / Z. Shevchuk, A. Filip, V. Shevchuk, E. Kashuba // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 34-37. — Бібліогр.: 22 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862656006301941760 |
|---|---|
| author | Shevchuk, Z. Filip, A. Shevchuk, V. Kashuba, E. |
| author_facet | Shevchuk, Z. Filip, A. Shevchuk, V. Kashuba, E. |
| citation_txt | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers / Z. Shevchuk, A. Filip, V. Shevchuk, E. Kashuba // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 34-37. — Бібліогр.: 22 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Background: It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. Aim: To count Langerhans cells, assessing expression levels of CD1A and CD207 markers in actinic keratosis, basal and squamous cell carcinomas, compared with the normal skin. Comparison of Langerhans cells might give a valuable prognostic marker for skin cancer. Methods: Immunohistochemistry and methods of statistics were used. Results: Expression of CD1A and CD207 markers was assessed in tumor samples of actinic keratosis, cutaneous basal and squamous cell carcinomas, in comparison with the normal skin. In each cohort there were 40 patients (and 11 healthy individuals). We have shown that the number of Langerhans cells is considerably lower in cutaneous basal and squamous cell carcinomas, compared with their number in the normal skin (p < 0.0001). Conclusions: CD1A expression correlated with CD207 expression only in the control group. There was no correlation in actinic keratosis, basal and squamous cell carcinoma. This may suggest an alteration of Langerhans cells phenotype in skin neoplastic diseases, making the number of Langerhans cells a valuable prognostic factor for skin tumors. Key Words: Langerhans cell, CD207, CD1A, actinic keratosis, skin cancer.
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| first_indexed | 2025-12-02T03:28:24Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145317 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-02T03:28:24Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Shevchuk, Z. Filip, A. Shevchuk, V. Kashuba, E. 2019-01-20T10:15:59Z 2019-01-20T10:15:59Z 2014 Number of Langerhans cells is decreased in premalignant keratosis and skin cancers / Z. Shevchuk, A. Filip, V. Shevchuk, E. Kashuba // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 34-37. — Бібліогр.: 22 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145317 Background: It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. Aim: To count Langerhans cells, assessing expression levels of CD1A and CD207 markers in actinic keratosis, basal and squamous cell carcinomas, compared with the normal skin. Comparison of Langerhans cells might give a valuable prognostic marker for skin cancer. Methods: Immunohistochemistry and methods of statistics were used. Results: Expression of CD1A and CD207 markers was assessed in tumor samples of actinic keratosis, cutaneous basal and squamous cell carcinomas, in comparison with the normal skin. In each cohort there were 40 patients (and 11 healthy individuals). We have shown that the number of Langerhans cells is considerably lower in cutaneous basal and squamous cell carcinomas, compared with their number in the normal skin (p < 0.0001). Conclusions: CD1A expression correlated with CD207 expression only in the control group. There was no correlation in actinic keratosis, basal and squamous cell carcinoma. This may suggest an alteration of Langerhans cells phenotype in skin neoplastic diseases, making the number of Langerhans cells a valuable prognostic factor for skin tumors. Key Words: Langerhans cell, CD207, CD1A, actinic keratosis, skin cancer. We thank Mariola Bigas for excellent technical assistance. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Number of Langerhans cells is decreased in premalignant keratosis and skin cancers Article published earlier |
| spellingShingle | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers Shevchuk, Z. Filip, A. Shevchuk, V. Kashuba, E. Original contributions |
| title | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers |
| title_full | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers |
| title_fullStr | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers |
| title_full_unstemmed | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers |
| title_short | Number of Langerhans cells is decreased in premalignant keratosis and skin cancers |
| title_sort | number of langerhans cells is decreased in premalignant keratosis and skin cancers |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145317 |
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