Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo
Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injecti...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2014 |
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| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/145329 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862713545216491520 |
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| author | Gevorkyan, L. Gambashidze, K. |
| author_facet | Gevorkyan, L. Gambashidze, K. |
| citation_txt | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide.
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| first_indexed | 2025-12-07T17:44:54Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145329 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T17:44:54Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Gevorkyan, L. Gambashidze, K. 2019-01-20T11:14:01Z 2019-01-20T11:14:01Z 2014 Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145329 Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Article published earlier |
| spellingShingle | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Gevorkyan, L. Gambashidze, K. Short communications |
| title | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_fullStr | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full_unstemmed | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_short | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_sort | anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145329 |
| work_keys_str_mv | AT gevorkyanl anticancerefficacyofhydroxyethylthiaminediphosphateinvivo AT gambashidzek anticancerefficacyofhydroxyethylthiaminediphosphateinvivo |