Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo
Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injecti...
Saved in:
| Published in: | Experimental Oncology |
|---|---|
| Date: | 2014 |
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145329 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| id |
nasplib_isofts_kiev_ua-123456789-145329 |
|---|---|
| record_format |
dspace |
| spelling |
Gevorkyan, L. Gambashidze, K. 2019-01-20T11:14:01Z 2019-01-20T11:14:01Z 2014 Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145329 Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| spellingShingle |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo Gevorkyan, L. Gambashidze, K. Short communications |
| title_short |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_fullStr |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_full_unstemmed |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| title_sort |
anticancer efficacy of hydroxyethylthiamine diphosphate in vivo |
| author |
Gevorkyan, L. Gambashidze, K. |
| author_facet |
Gevorkyan, L. Gambashidze, K. |
| topic |
Short communications |
| topic_facet |
Short communications |
| publishDate |
2014 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Aim: The aim of the presented article was investigation of anticancer efficacy of hydroxyethylthiamine diphosphate (HTD) in vivo. Materials and Methods: The study was carried out on 30 C57BL/6J mice subcutaneously transplanted with Ehrlich carcinoma. Animals were treated with intraperitoneal injections of the solution composed from pyruvic acid and thiamine bromide every other day during 10 days and thereafter, every day during 2 weeks. Treatment efficacy was evaluated by tumor growth inhibition. Results: In experimental animals treated with HTD, significant tumor growth inhibition has been registered: 73% at day 45th compared to the control group (p < 0.001). Conclusion: Treatment with HTD demonstrated high anticancer efficacy in vivo. Key Words: carcinogenesis, pH, hydroxyethylthiamine diphosphate, lipoic acid amide.
|
| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145329 |
| citation_txt |
Anticancer efficacy of hydroxyethylthiamine diphosphate in vivo / L. Gevorkyan, K. Gambashidze // Experimental Oncology. — 2014. — Т. 36, № 1. — С. 48-49. — Бібліогр.: 3 назв. — англ. |
| work_keys_str_mv |
AT gevorkyanl anticancerefficacyofhydroxyethylthiaminediphosphateinvivo AT gambashidzek anticancerefficacyofhydroxyethylthiaminediphosphateinvivo |
| first_indexed |
2025-12-07T17:44:54Z |
| last_indexed |
2025-12-07T17:44:54Z |
| _version_ |
1850872424490336256 |