Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer

Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer

Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod...

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Published in:Experimental Oncology
Date:2014
Main Authors: Kiselev, V.I., Drukh, V.M., Muyzhnek, E.L., Kuznetsov, I.N., Pchelintseva, O.I., Paltsev, M.A.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145337
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145337
record_format dspace
spelling Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
2019-01-20T16:36:21Z
2019-01-20T16:36:21Z
2014
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145337
Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies.
Research and experimental studies were carried out at the FGBOU VPO Peoples’ Friendship University of Russia in the context of Project “Production of drugs based on biotechnology for the treatment of socially significant diseases”, financed by Presidential Grant of The Russian Ministry of Education and Science in compliance with Russian Government’s decree № 218.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
spellingShingle Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
Original contributions
title_short Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_full Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_fullStr Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_full_unstemmed Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
title_sort preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
author Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
author_facet Kiselev, V.I.
Drukh, V.M.
Muyzhnek, E.L.
Kuznetsov, I.N.
Pchelintseva, O.I.
Paltsev, M.A.
topic Original contributions
topic_facet Original contributions
publishDate 2014
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145337
citation_txt Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ.
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AT drukhvm preclinicalantitumoractivityofthediindolylmethaneformulationinxenograftmousemodelofprostatecancer
AT muyzhnekel preclinicalantitumoractivityofthediindolylmethaneformulationinxenograftmousemodelofprostatecancer
AT kuznetsovin preclinicalantitumoractivityofthediindolylmethaneformulationinxenograftmousemodelofprostatecancer
AT pchelintsevaoi preclinicalantitumoractivityofthediindolylmethaneformulationinxenograftmousemodelofprostatecancer
AT paltsevma preclinicalantitumoractivityofthediindolylmethaneformulationinxenograftmousemodelofprostatecancer
first_indexed 2025-12-01T06:39:59Z
last_indexed 2025-12-01T06:39:59Z
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