Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2014 |
| Автори: | , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145337 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862642786569814016 |
|---|---|
| author | Kiselev, V.I. Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. |
| author_facet | Kiselev, V.I. Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. |
| citation_txt | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies.
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| first_indexed | 2025-12-01T06:39:59Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145337 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-01T06:39:59Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kiselev, V.I. Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. 2019-01-20T16:36:21Z 2019-01-20T16:36:21Z 2014 Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer / V.I. Kiselev, V.M. Drukh, E.L. Muyzhnek, I.N. Kuznetsov, O.I. Pchelintseva, M.A. Paltsev // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 90-93. — Бібліогр.: 20 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145337 Aim: Preclinical study of the specific anticancer pharmacological activity of the formulation containing active substance 3,3ʹ-diindolylmethane (DIM), cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E), in vivo in a xenograft animal model of LNCaP. Materials and Methods: The DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) formulation was intragastrically administered to BALB/c-nude (nu/nu) mice during 33 days post inoculation at the dose of 133 mg/kg/day. Antitumor activity of the test drug was estimated by the rate of tumor growth inhibition (T/C% — treated versus control), dividing the tumor volumes from treatment groups with the control groups. Results: Statistically significant tumor xenograft regressions have been shown in group which received the DIM, cod liver oil, polysorbate 80 and α-tocopherol acetate (vitamin E) on the 37th day of observation post inoculation. The highest antitumor activity was achieved on the 39th day (T/C = 16,8%). Therapeutic effect lasts for 6 days after the end of therapy period. Conclusion: Our findings demonstrate inhibitory effect of the formulation on tumor development in the xenograft animal model due to the tumor growth rate reduction. Key Words: 3,3´-diindolylmethane, bioavailability, anticancer activity, xenograft model, LNCaP cell line, preclinical studies. Research and experimental studies were carried out at the FGBOU VPO Peoples’ Friendship University of Russia in the context of Project “Production of drugs based on biotechnology for the treatment of socially significant diseases”, financed by Presidential Grant of The Russian Ministry of Education and Science in compliance with Russian Government’s decree № 218. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer Article published earlier |
| spellingShingle | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer Kiselev, V.I. Drukh, V.M. Muyzhnek, E.L. Kuznetsov, I.N. Pchelintseva, O.I. Paltsev, M.A. Original contributions |
| title | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| title_full | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| title_fullStr | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| title_full_unstemmed | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| title_short | Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| title_sort | preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145337 |
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