Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer

Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer

Aim: To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer. Materials and Methods: The activity of adenosine deaminase, xanthine oxidase, glutathione peroxidase, superoxide dismutase and glucose-6-p...

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Veröffentlicht in:Experimental Oncology
Datum:2014
Hauptverfasser: Zuikov, S.A., Borzenko, B.G., Shatova, O.P., Bakurova, E.M., Polunin, G.E.
Format: Artikel
Sprache:English
Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
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Online Zugang:https://nasplib.isofts.kiev.ua/handle/123456789/145341
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Zitieren:Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer / S.A. Zuikov, B.G. Borzenko, O.P. Shatova, E.M. Bakurova, G.E. Polunin // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 17-120. — Бібліогр.: 24 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145341
record_format dspace
spelling Zuikov, S.A.
Borzenko, B.G.
Shatova, O.P.
Bakurova, E.M.
Polunin, G.E.
2019-01-20T18:03:26Z
2019-01-20T18:03:26Z
2014
Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer / S.A. Zuikov, B.G. Borzenko, O.P. Shatova, E.M. Bakurova, G.E. Polunin // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 17-120. — Бібліогр.: 24 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145341
Aim: To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer. Materials and Methods: The activity of adenosine deaminase, xanthine oxidase, glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase, the NOx concentration and the oxidative modification of proteins were determined spectrophotometricaly in 50 apparently healthy people and 26 patients with colorectal cancer stage ­III–­­IV, aged 40 to 79 years. Results: Increase of pro-oxidant system of erythrocytes with the age against decrease in level of antioxidant protection in both healthy individuals and colorectal cancer patients was determined. A significant increase of pro­ducts of oxidative proteins modification in erythrocytes with ageing was shown. Statistically significant correlation between enzymatic and non enzymatic markers pro-oxidant system and the activity of antioxidant defense enzymes in erythrocytes of patient with colorectal cancer was determined. Conclusion: Obtained results have demonstrated the imbalance in the antioxidant system of erythrocytes in colorectal cancer patients that improve the survival of cancer cells that is more distinctly manifested in ageing. Key Words: age, colorectal cancer, erythrocyte, nucleotides, antioxidants, oxidative stress.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
spellingShingle Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
Zuikov, S.A.
Borzenko, B.G.
Shatova, O.P.
Bakurova, E.M.
Polunin, G.E.
Original contributions
title_short Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
title_full Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
title_fullStr Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
title_full_unstemmed Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
title_sort correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer
author Zuikov, S.A.
Borzenko, B.G.
Shatova, O.P.
Bakurova, E.M.
Polunin, G.E.
author_facet Zuikov, S.A.
Borzenko, B.G.
Shatova, O.P.
Bakurova, E.M.
Polunin, G.E.
topic Original contributions
topic_facet Original contributions
publishDate 2014
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To examine the relationship between metabolic features of purine nucleotides and antioxidant system depending on the age of patients with colorectal cancer. Materials and Methods: The activity of adenosine deaminase, xanthine oxidase, glutathione peroxidase, superoxide dismutase and glucose-6-phosphate dehydrogenase, the NOx concentration and the oxidative modification of proteins were determined spectrophotometricaly in 50 apparently healthy people and 26 patients with colorectal cancer stage ­III–­­IV, aged 40 to 79 years. Results: Increase of pro-oxidant system of erythrocytes with the age against decrease in level of antioxidant protection in both healthy individuals and colorectal cancer patients was determined. A significant increase of pro­ducts of oxidative proteins modification in erythrocytes with ageing was shown. Statistically significant correlation between enzymatic and non enzymatic markers pro-oxidant system and the activity of antioxidant defense enzymes in erythrocytes of patient with colorectal cancer was determined. Conclusion: Obtained results have demonstrated the imbalance in the antioxidant system of erythrocytes in colorectal cancer patients that improve the survival of cancer cells that is more distinctly manifested in ageing. Key Words: age, colorectal cancer, erythrocyte, nucleotides, antioxidants, oxidative stress.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145341
citation_txt Correlation of nucleotides and carbohydrates metabolism with pro-oxidant and antioxidant systems of erythrocytes depending on age in patients with colorectal cancer / S.A. Zuikov, B.G. Borzenko, O.P. Shatova, E.M. Bakurova, G.E. Polunin // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 17-120. — Бібліогр.: 24 назв. — англ.
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first_indexed 2025-12-07T17:14:09Z
last_indexed 2025-12-07T17:14:09Z
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