Clinical significance of hormonal receptor status of malignant ovarian tumors

Clinical significance of hormonal receptor status of malignant ovarian tumors

Objectives: To study hormonal receptor status (HRS) of malignant ovarian tumors (MOT) and determine its clinical significance. Patients and Methods: Retrospective analysis of case histories of 284 patients with MOT of different genesis of I–IV stages was carried out; immunohistochemical study of par...

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Бібліографічні деталі
Опубліковано в: :Experimental Oncology
Дата:2014
Автори: Tkalia, I.G., Vorobyova, L.I., Svintsitsky, V.S., Nespryadko, S.V., Goncharuk, I.V., Lukyanova, N.Y., Chekhun, V.F.
Формат: Стаття
Мова:English
Опубліковано: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
Теми:
Original contributions
Онлайн доступ:https://nasplib.isofts.kiev.ua/handle/123456789/145343
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Назва журналу:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Цитувати:Clinical significance of hormonal receptor status of malignant ovarian tumors / I.G. Tkalia, L.I. Vorobyova, V.S. Svintsitsky, S.V. Nespryadko, I.V. Goncharuk, N.Y. Lukyanova, V.F. Chekhun // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 125-133. — Бібліогр.: 39 назв. — англ.

Репозитарії

Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145343
record_format dspace
spelling Tkalia, I.G.
Vorobyova, L.I.
Svintsitsky, V.S.
Nespryadko, S.V.
Goncharuk, I.V.
Lukyanova, N.Y.
Chekhun, V.F.
2019-01-20T18:05:46Z
2019-01-20T18:05:46Z
2014
Clinical significance of hormonal receptor status of malignant ovarian tumors / I.G. Tkalia, L.I. Vorobyova, V.S. Svintsitsky, S.V. Nespryadko, I.V. Goncharuk, N.Y. Lukyanova, V.F. Chekhun // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 125-133. — Бібліогр.: 39 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145343
Objectives: To study hormonal receptor status (HRS) of malignant ovarian tumors (MOT) and determine its clinical significance. Patients and Methods: Retrospective analysis of case histories of 284 patients with MOT of different genesis of I–IV stages was carried out; immunohistochemical study of paraffin-embedded tissues. The HRS for serous, mucinous ovarian cancer (OC) and sex cord-stromal tumors (SCST) was studied. The phenotype of tumors by HRS in patients with serous OC was determined; overall and relapse-free survival in these patients was evaluated depending on the tumor HRS. Results: Positive expression of ER has been registered in 66.4% of patients with serous OC, PR — in 63.4%, TR — in 53.0%; in patients with mucinous OC — 88.0; 84.0; 60.0%, respectively. Positive staining of cells of stroma-cellular tumors has been observed in 74.1% of patients for ER and 77.8% — for PR and TR. The highest number of patients with tumor phenotype ER+PR+TR+ has been observed in postmenopause — 52.4%, especially in late postmenopausal period — 39.0%. The lowest percentage of patients with mentioned phenotype has been marked in reproductive age — 20.7%. Most patients of reproductive period had phenotype of tumor ER-PR-TR- (35.1%), in late postmenopause this phenotype has been observed only in 16.2%. The patients with serous OC with the positive tumor HRS demonstrated the low indices of overall and relapse-free survival compared to the patients with receptor-negative tumors con­cerning all steroid hormones (р < 0.05). Conclusions: Positive HRS was registered in serous, mucinous OC and in SCST, high percen­tage of tumors with expression of all receptors of steroid hormones was observed at that. The highest frequency of tumors with positive HRS was recorded in patients with serous OC of late postmenopausal period. The patients with serous OC with receptor-positive tumor phenotype showed the rates of overall and relapse-free survival significantly lower compared to the patients with receptor-negative phenotype of OC. Positive HRS, the same as strong expression of TR in patients with serous OC, is a predictive factor of unfavorable course of tumor process. HRS of MOT can be regarded as the additional criterion for solution of a question concerning application of hormonal therapy as a component of complex treatment for the patients. Key Words: malignant ovarian tumors, serous ovarian cancer, hormonal receptor status, estrogen, progesterone, testosterone receptors, phenotype of tumor.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Clinical significance of hormonal receptor status of malignant ovarian tumors
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Clinical significance of hormonal receptor status of malignant ovarian tumors
spellingShingle Clinical significance of hormonal receptor status of malignant ovarian tumors
Tkalia, I.G.
Vorobyova, L.I.
Svintsitsky, V.S.
Nespryadko, S.V.
Goncharuk, I.V.
Lukyanova, N.Y.
Chekhun, V.F.
Original contributions
title_short Clinical significance of hormonal receptor status of malignant ovarian tumors
title_full Clinical significance of hormonal receptor status of malignant ovarian tumors
title_fullStr Clinical significance of hormonal receptor status of malignant ovarian tumors
title_full_unstemmed Clinical significance of hormonal receptor status of malignant ovarian tumors
title_sort clinical significance of hormonal receptor status of malignant ovarian tumors
author Tkalia, I.G.
Vorobyova, L.I.
Svintsitsky, V.S.
Nespryadko, S.V.
Goncharuk, I.V.
Lukyanova, N.Y.
Chekhun, V.F.
author_facet Tkalia, I.G.
Vorobyova, L.I.
Svintsitsky, V.S.
Nespryadko, S.V.
Goncharuk, I.V.
Lukyanova, N.Y.
Chekhun, V.F.
topic Original contributions
topic_facet Original contributions
publishDate 2014
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Objectives: To study hormonal receptor status (HRS) of malignant ovarian tumors (MOT) and determine its clinical significance. Patients and Methods: Retrospective analysis of case histories of 284 patients with MOT of different genesis of I–IV stages was carried out; immunohistochemical study of paraffin-embedded tissues. The HRS for serous, mucinous ovarian cancer (OC) and sex cord-stromal tumors (SCST) was studied. The phenotype of tumors by HRS in patients with serous OC was determined; overall and relapse-free survival in these patients was evaluated depending on the tumor HRS. Results: Positive expression of ER has been registered in 66.4% of patients with serous OC, PR — in 63.4%, TR — in 53.0%; in patients with mucinous OC — 88.0; 84.0; 60.0%, respectively. Positive staining of cells of stroma-cellular tumors has been observed in 74.1% of patients for ER and 77.8% — for PR and TR. The highest number of patients with tumor phenotype ER+PR+TR+ has been observed in postmenopause — 52.4%, especially in late postmenopausal period — 39.0%. The lowest percentage of patients with mentioned phenotype has been marked in reproductive age — 20.7%. Most patients of reproductive period had phenotype of tumor ER-PR-TR- (35.1%), in late postmenopause this phenotype has been observed only in 16.2%. The patients with serous OC with the positive tumor HRS demonstrated the low indices of overall and relapse-free survival compared to the patients with receptor-negative tumors con­cerning all steroid hormones (р < 0.05). Conclusions: Positive HRS was registered in serous, mucinous OC and in SCST, high percen­tage of tumors with expression of all receptors of steroid hormones was observed at that. The highest frequency of tumors with positive HRS was recorded in patients with serous OC of late postmenopausal period. The patients with serous OC with receptor-positive tumor phenotype showed the rates of overall and relapse-free survival significantly lower compared to the patients with receptor-negative phenotype of OC. Positive HRS, the same as strong expression of TR in patients with serous OC, is a predictive factor of unfavorable course of tumor process. HRS of MOT can be regarded as the additional criterion for solution of a question concerning application of hormonal therapy as a component of complex treatment for the patients. Key Words: malignant ovarian tumors, serous ovarian cancer, hormonal receptor status, estrogen, progesterone, testosterone receptors, phenotype of tumor.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145343
citation_txt Clinical significance of hormonal receptor status of malignant ovarian tumors / I.G. Tkalia, L.I. Vorobyova, V.S. Svintsitsky, S.V. Nespryadko, I.V. Goncharuk, N.Y. Lukyanova, V.F. Chekhun // Experimental Oncology. — 2014. — Т. 36, № 2. — С. 125-133. — Бібліогр.: 39 назв. — англ.
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first_indexed 2025-11-28T17:32:42Z
last_indexed 2025-11-28T17:32:42Z
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