The phenomenon of multi-drug resistance in the treatment of malignant tumors

• Published in: Experimental Oncology
• Date: 2014
• Main Authors: Vtorushin, S.V., Khristenko, K.Y., Zavyalova, M.V., Perelmuter, V.M., Litviakov, N.V., Denisov, E.V., Dulesova, A.Y., Cherdyntseva, N.V.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145358
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.

Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre­ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.