The phenomenon of multi-drug resistance in the treatment of malignant tumors

The phenomenon of multi-drug resistance in the treatment of malignant tumors

Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre­ating breast cancer. Physiologic...

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Published in:Experimental Oncology
Date:2014
Main Authors: Vtorushin, S.V., Khristenko, K.Y., Zavyalova, M.V., Perelmuter, V.M., Litviakov, N.V., Denisov, E.V., Dulesova, A.Y., Cherdyntseva, N.V.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
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Reviews
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145358
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145358
record_format dspace
spelling Vtorushin, S.V.
Khristenko, K.Y.
Zavyalova, M.V.
Perelmuter, V.M.
Litviakov, N.V.
Denisov, E.V.
Dulesova, A.Y.
Cherdyntseva, N.V.
2019-01-20T20:49:24Z
2019-01-20T20:49:24Z
2014
The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145358
Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre­ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.
The study is supported by the grants № 14–04– 31727/14 and № 13–04–98111 r_Sibir_a of Russian Foundation of Basic Research (RFBR) and Grant of the President of the Russian Federation (agreement 14.122.13.491-MD).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Reviews
The phenomenon of multi-drug resistance in the treatment of malignant tumors
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title The phenomenon of multi-drug resistance in the treatment of malignant tumors
spellingShingle The phenomenon of multi-drug resistance in the treatment of malignant tumors
Vtorushin, S.V.
Khristenko, K.Y.
Zavyalova, M.V.
Perelmuter, V.M.
Litviakov, N.V.
Denisov, E.V.
Dulesova, A.Y.
Cherdyntseva, N.V.
Reviews
title_short The phenomenon of multi-drug resistance in the treatment of malignant tumors
title_full The phenomenon of multi-drug resistance in the treatment of malignant tumors
title_fullStr The phenomenon of multi-drug resistance in the treatment of malignant tumors
title_full_unstemmed The phenomenon of multi-drug resistance in the treatment of malignant tumors
title_sort phenomenon of multi-drug resistance in the treatment of malignant tumors
author Vtorushin, S.V.
Khristenko, K.Y.
Zavyalova, M.V.
Perelmuter, V.M.
Litviakov, N.V.
Denisov, E.V.
Dulesova, A.Y.
Cherdyntseva, N.V.
author_facet Vtorushin, S.V.
Khristenko, K.Y.
Zavyalova, M.V.
Perelmuter, V.M.
Litviakov, N.V.
Denisov, E.V.
Dulesova, A.Y.
Cherdyntseva, N.V.
topic Reviews
topic_facet Reviews
publishDate 2014
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre­ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145358
citation_txt The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ.
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first_indexed 2025-11-30T23:10:20Z
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