The phenomenon of multi-drug resistance in the treatment of malignant tumors
Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in treating breast cancer. Physiologic...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2014 |
| Автори: | , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Теми: | |
| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145358 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ. |
Репозитарії
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1859688920451645441 |
|---|---|
| author | Vtorushin, S.V. Khristenko, K.Y. Zavyalova, M.V. Perelmuter, V.M. Litviakov, N.V. Denisov, E.V. Dulesova, A.Y. Cherdyntseva, N.V. |
| author_facet | Vtorushin, S.V. Khristenko, K.Y. Zavyalova, M.V. Perelmuter, V.M. Litviakov, N.V. Denisov, E.V. Dulesova, A.Y. Cherdyntseva, N.V. |
| citation_txt | The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in treating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes.
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| first_indexed | 2025-11-30T23:10:20Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145358 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-30T23:10:20Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Vtorushin, S.V. Khristenko, K.Y. Zavyalova, M.V. Perelmuter, V.M. Litviakov, N.V. Denisov, E.V. Dulesova, A.Y. Cherdyntseva, N.V. 2019-01-20T20:49:24Z 2019-01-20T20:49:24Z 2014 The phenomenon of multi-drug resistance in the treatment of malignant tumors / S.V. Vtorushin, K.Y. Khristenko, M.V. Zavyalova, V.M. Perelmuter, N.V. Litviakov, E.V. Denisov, A.Y. Dulesova, N.V. Cherdyntseva // Experimental Oncology. — 2014. — Т. 36, № 3. — С. 144-156. — Бібліогр.: 191 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145358 Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in treating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown. Key Words: multi-drug resistance, ABC-transporters, glutathione system, apoptosis-controlling genes. The study is supported by the grants № 14–04– 31727/14 and № 13–04–98111 r_Sibir_a of Russian Foundation of Basic Research (RFBR) and Grant of the President of the Russian Federation (agreement 14.122.13.491-MD). en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews The phenomenon of multi-drug resistance in the treatment of malignant tumors Article published earlier |
| spellingShingle | The phenomenon of multi-drug resistance in the treatment of malignant tumors Vtorushin, S.V. Khristenko, K.Y. Zavyalova, M.V. Perelmuter, V.M. Litviakov, N.V. Denisov, E.V. Dulesova, A.Y. Cherdyntseva, N.V. Reviews |
| title | The phenomenon of multi-drug resistance in the treatment of malignant tumors |
| title_full | The phenomenon of multi-drug resistance in the treatment of malignant tumors |
| title_fullStr | The phenomenon of multi-drug resistance in the treatment of malignant tumors |
| title_full_unstemmed | The phenomenon of multi-drug resistance in the treatment of malignant tumors |
| title_short | The phenomenon of multi-drug resistance in the treatment of malignant tumors |
| title_sort | phenomenon of multi-drug resistance in the treatment of malignant tumors |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145358 |
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