Characterization of breast cancer DNA content profiles as a prognostic tool
Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only beca...
Saved in:
| Published in: | Experimental Oncology |
|---|---|
| Date: | 2014 |
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
|
| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145371 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. |
Institution
Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862571656525905920 |
|---|---|
| author | Gerashchenko, B.I. Huna, A. Erenpreisa, J. |
| author_facet | Gerashchenko, B.I. Huna, A. Erenpreisa, J. |
| citation_txt | Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only because of the selection of mutated aneuploid sub-clones that stipulate the tumor progression, but also because of the reversible endopolyploidy of tumor cells that serves for the endless maintenance of therapy-resistant tumor stem cells. Therefore, cytometric determination of DNA content in tissue samples for detecting malignancy, monitoring responses to therapy, and prognosing disease outcome needs to be revived. Both flow and image cytometry are most frequently used for generation of DNA content profiles (histograms), interpretation of which, however, may have some caveats. This review presents the major characterization criteria and analysis tools for breast cancer DNA histograms. Key Words: breast cancer, aneuploidy, DNA content analysis, DNA histogram, flow cytometry, image cytometry.
|
| first_indexed | 2025-11-26T03:18:01Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145371 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-26T03:18:01Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Gerashchenko, B.I. Huna, A. Erenpreisa, J. 2019-01-21T08:27:56Z 2019-01-21T08:27:56Z 2014 Characterization of breast cancer DNA content profiles as a prognostic tool / B.I. Gerashchenko, A. Huna, J. Erenpreisa // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 219-225. — Бібліогр.: 74 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145371 Worldwide, breast cancer in women remains to be the most common malignancy that in a considerable proportion shows the resistance to genotoxic treatments and poor outcome. Chromosomal instability manifested as aneuploidy represents an integral characteristics of the malignant genotype not only because of the selection of mutated aneuploid sub-clones that stipulate the tumor progression, but also because of the reversible endopolyploidy of tumor cells that serves for the endless maintenance of therapy-resistant tumor stem cells. Therefore, cytometric determination of DNA content in tissue samples for detecting malignancy, monitoring responses to therapy, and prognosing disease outcome needs to be revived. Both flow and image cytometry are most frequently used for generation of DNA content profiles (histograms), interpretation of which, however, may have some caveats. This review presents the major characterization criteria and analysis tools for breast cancer DNA histograms. Key Words: breast cancer, aneuploidy, DNA content analysis, DNA histogram, flow cytometry, image cytometry. This work is supported by the European Social Fund (grant number: 1DP/1.1.1.2/APIA/VIAA/037). en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Characterization of breast cancer DNA content profiles as a prognostic tool Article published earlier |
| spellingShingle | Characterization of breast cancer DNA content profiles as a prognostic tool Gerashchenko, B.I. Huna, A. Erenpreisa, J. Reviews |
| title | Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_full | Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_fullStr | Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_full_unstemmed | Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_short | Characterization of breast cancer DNA content profiles as a prognostic tool |
| title_sort | characterization of breast cancer dna content profiles as a prognostic tool |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145371 |
| work_keys_str_mv | AT gerashchenkobi characterizationofbreastcancerdnacontentprofilesasaprognostictool AT hunaa characterizationofbreastcancerdnacontentprofilesasaprognostictool AT erenpreisaj characterizationofbreastcancerdnacontentprofilesasaprognostictool |