Precision therapy to target apoptosis in prostate cancer
Androgen-independent prostate cancer shows limited response to existing systemic therapies. Recent advances in prostate-selective targeting of small molecule inhibitors and bacterial toxins have created opportunities to design a new generation of therapies for advanced prostate cancer. Yet prioritiz...
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| Published in: | Experimental Oncology |
|---|---|
| Date: | 2014 |
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145372 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Precision therapy to target apoptosis in prostate cancer / G. Kulik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 226-230. — Бібліогр.: 48 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862690274285715456 |
|---|---|
| author | Kulik, G. |
| author_facet | Kulik, G. |
| citation_txt | Precision therapy to target apoptosis in prostate cancer / G. Kulik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 226-230. — Бібліогр.: 48 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Androgen-independent prostate cancer shows limited response to existing systemic therapies. Recent advances in prostate-selective targeting of small molecule inhibitors and bacterial toxins have created opportunities to design a new generation of therapies for advanced prostate cancer. Yet prioritizing targets for these therapies remain challenging, since multiple mechanisms contribute to the pathophysiology of androgen-independent prostate cancer. This review explores the possibility of targeting the apoptosis regulatory network as most direct approach to efficient treatment of advanced androgen-independent prostate cancer. Key Words: prostate cancer, apoptosis, prostate-selective therapies, PSA-activated pro-drugs, PSMA-targeting toxins.
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| first_indexed | 2025-12-07T16:13:04Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145372 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T16:13:04Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Kulik, G. 2019-01-21T08:29:32Z 2019-01-21T08:29:32Z 2014 Precision therapy to target apoptosis in prostate cancer / G. Kulik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 226-230. — Бібліогр.: 48 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145372 Androgen-independent prostate cancer shows limited response to existing systemic therapies. Recent advances in prostate-selective targeting of small molecule inhibitors and bacterial toxins have created opportunities to design a new generation of therapies for advanced prostate cancer. Yet prioritizing targets for these therapies remain challenging, since multiple mechanisms contribute to the pathophysiology of androgen-independent prostate cancer. This review explores the possibility of targeting the apoptosis regulatory network as most direct approach to efficient treatment of advanced androgen-independent prostate cancer. Key Words: prostate cancer, apoptosis, prostate-selective therapies, PSA-activated pro-drugs, PSMA-targeting toxins. This work was supported by Internal Research Grant (IRG2014 Project number 4071101011411) from Alfaisal University. The author is grateful to Karen Klein (Biomedical Research Services and Administration, Wake Forest University Health Sciences) for manuscript editing. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Reviews Precision therapy to target apoptosis in prostate cancer Article published earlier |
| spellingShingle | Precision therapy to target apoptosis in prostate cancer Kulik, G. Reviews |
| title | Precision therapy to target apoptosis in prostate cancer |
| title_full | Precision therapy to target apoptosis in prostate cancer |
| title_fullStr | Precision therapy to target apoptosis in prostate cancer |
| title_full_unstemmed | Precision therapy to target apoptosis in prostate cancer |
| title_short | Precision therapy to target apoptosis in prostate cancer |
| title_sort | precision therapy to target apoptosis in prostate cancer |
| topic | Reviews |
| topic_facet | Reviews |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145372 |
| work_keys_str_mv | AT kulikg precisiontherapytotargetapoptosisinprostatecancer |