Hypoxia enhances antitumor activity of dichloroacetate
It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy metabolism of tumor cells from aerobic glycolysis towards oxidative phosphoryla...
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| Published in: | Experimental Oncology |
|---|---|
| Date: | 2014 |
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Subjects: | |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145373 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Hypoxia enhances antitumor activity of dichloroacetate / D.L. Kolesnik, O.N. Pyaskovskaya, I.V. Boichuk, G.I. Solyanik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 231-235. — Бібліогр.: 14 назв. — англ. |