Cover Image

Hypoxia enhances antitumor activity of dichloroacetate

It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy metabolism of tumor cells from aerobic glycolysis towards oxidative phosphoryla...

Full description

Saved in:

Bibliographic Details
Published in:	Experimental Oncology
Date:	2014
Main Authors:	Kolesnik, D.L., Pyaskovskaya, O.N., Boichuk, I.V., Solyanik, G.I.
Format:	Article
Language:	English
Published:	Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
Subjects:	Original contributions
Online Access:	https://nasplib.isofts.kiev.ua/handle/123456789/145373
Tags:	Add Tag No Tags, Be the first to tag this record!
Journal Title:	Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:	Hypoxia enhances antitumor activity of dichloroacetate / D.L. Kolesnik, O.N. Pyaskovskaya, I.V. Boichuk, G.I. Solyanik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 231-235. — Бібліогр.: 14 назв. — англ.

Institution

Digital Library of Periodicals of National Academy of Sciences of Ukraine

Similar Items

Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma
by: Pyaskovskaya, O.N., et al.
Published: (2015)

Hypoxia enhances antitumor activity of dichloroacetate
by: D. L. Kolesnik, et al.
Published: (2014)

Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6
by: Prokhorova, I.V., et al.
Published: (2018)

Effect of dichloroacetate on Lewis lung carcinoma growth and metastasis
by: Kolesnik, D.L., et al.
Published: (2015)

Effectiveness of sodium dichloroacetate against glioma с6 depends on administration schedule and dosage
by: Fedorchuk, A.G., et al.
Published: (2016)

Cytotoxic activity of metformin in vitro does not correlate with its antitumor action in vivo
by: Pyaskovskaya, O.N., et al.
Published: (2017)

Metformin enhances antitumor action of sodium dichloroacetate against glioma C6
by: Kolesnik, D.L., et al.
Published: (2023)

Impact of lactic acidosis on the survival of lewis lung carcinoma cells
by: Kolesnik, D.L., et al.
Published: (2017)

Aconitine-containing agent enhances antitumor activity of dichloroacetate against Ehrlich carcinoma
by: O. N. Pyaskovskaya, et al.
Published: (2015)

Dynamics of changes of antioxidant system indexes during the growth of two Lewis lung carcinoma variants
by: Pyaskovskaya, O.N., et al.
Published: (2014)

Analysis of growth kinetics and proliferative heterogeneity of Lewis lung carcinoma cells growing as unfed culture
by: Pyaskovskaya, O.N., et al.
Published: (2008)

Enhancing effect of new biological response modifier sulfoethylated (1→3)-β-D-glucan on antitumor activity of cyclophosphamide in the treatment
by: Khalikova, T.A., et al.
Published: (2006)

The influence of sodium dichloroacetate on the oxidative processes in sarcoma 37
by: Sorokina, L.V., et al.
Published: (2011)

Metformin enhances cytotoxic action of dichloroacetate against Lewis lung carcinoma cells in vitro
by: Kolesnik, D.L., et al.
Published: (2023)

Changes in VEGF level and tumor growth characteristics during lewis lung carcinoma progression towards CIS-DDP resistance
by: Pyaskovskaya, O.N., et al.
Published: (2007)

Antitumor activity of polyphenolic extract of Ichnocarpus frutescens
by: Kumarappan, C.T., et al.
Published: (2007)

Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer
by: Kiselev, V.I., et al.
Published: (2014)

Antitumor and antimetastatic activities of vaccine prepared from cisplatin-resistant lewis lung carcinoma
by: Potebnya, G.P., et al.
Published: (2009)

Cooperative antitumor effect of endothelial-monocyte activating polypeptide II and flutamide on human prostate cancer xenografts
by: Reznikov, A.G., et al.
Published: (2011)

Influence of doxorubicin inclusion into phospholipid nanoformulation on its antitumor activity in mice: increased efficiency for resistant tumor model
by: Zykova, M.G., et al.
Published: (2012)

Effects of radical oxygen species and no: formation of intracellular hypoxia and activation of matrix metalloproteinases in tumor tissues
by: Burlaka, A.P., et al.
Published: (2006)

Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats
by: Chekhun, V.F., et al.
Published: (2018)

Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice
by: Bozeman, E.N., et al.
Published: (2012)

In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents
by: Sen, A., et al.
Published: (2015)

TNFα receptor1 drives hypoxia-promoted invasiveness of human melanoma cells
by: Marconi C., et al.
Published: (2013)

Antitumor and adjuvant effects of phagelysates of E.coli in mice with Ehrlich carcinoma
by: Gambashidze, K., et al.
Published: (2012)

Antitumor action of lymphokin-activated сеlls of patients with soft tissue sarcomas and melanomas in dependence on expression of MHC classes I and II antigenes
by: Berezhnaya, N.M., et al.
Published: (2006)

Superoxide- and no-dependent mechanisms of antitumor and antimetastatic effect of L-arginine hydrochloride and coenzyme Q₁₀
by: Burlaka, A.P., et al.
Published: (2016)

Premorphological alterations in gastric mucosa in patients with gastric cancer: hypoxia level assessed by 31P NMR spectroscopy
by: Bubnovskaya, L., et al.
Published: (2014)

synthesis and evaluation of dimethyl tin 4-cyclohexyl thiosemicarbazone as a novel antitumor age
by: Sen, A., et al.
Published: (2009)

In vivo and in vitro antitumor effects of nutrient mixture in murine leukemia cell line P-388
by: Roomi, M.W., et al.
Published: (2011)

Time-dependent cytotoxicity of dichloroacetate and metformin against Lewis lung carcinoma
by: Kolesnik, D.L., et al.
Published: (2023)

Bioenergetic status and hypoxia in Lewis lung carcinoma assessed by 31P NMR spectroscopy: correlation with tumor progression
by: Bubnovskaya, L., et al.
Published: (2007)

Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro
by: Bezdieniezhnykh, N., et al.
Published: (2017)

The evaluation of prooxidant and antioxidant state of two variants of lewis lung carcinoma: a comparative study
by: Sorokina, L.V., et al.
Published: (2010)

Expression of CD40 by the cells of benign and malignant breast tumors and antitumor action of autologous lymphocytes against chemoresistant and chemosensitive tumors
by: Bereznaya, N.M., et al.
Published: (2008)

Photocytotoxic effect of C₆₀ fullerene against L1210 leukemic cells is accomPanied by enhanced nitric oxide Production and p38 maPk activation
by: Franskevych, D.V., et al.
Published: (2016)

Alterations of antitumor and metabolic responses in L5178Y-R lymphoma-bearing mice after only 30-minute daily chronic stress exposure
by: Caballero-Hernandez, D., et al.
Published: (2017)

Depressive-like psychoemotional state versus acute stresses enhances Lewis lung carcinoma metastasis in C57BL/6J mice
by: Amikishieva, A.V., et al.
Published: (2011)

Contrast-enhanced ultrasound monitoring of perfusion changes in hepatic neuroendocrine metastases after systemic versus selective arterial ¹⁷⁷Lu/⁹⁰Y-DOTATOC and ²¹³Bi-DOTATOC radiopeptide therapy
by: Giesel, F.L., et al.
Published: (2013)