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Hypoxia enhances antitumor activity of dichloroacetate

It is known that glycolysis contributes to the survival of tumor cells by providing them with energetic and plastic substrates. Dichloroacetate (DCA) as inhibitor of kinase pyruvate dehydrogenase shifts balance of energy metabolism of tumor cells from aerobic glycolysis towards oxidative phosphoryla...

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Veröffentlicht in:	Experimental Oncology
Datum:	2014
Hauptverfasser:	Kolesnik, D.L., Pyaskovskaya, O.N., Boichuk, I.V., Solyanik, G.I.
Format:	Artikel
Sprache:	Englisch
Veröffentlicht:	Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
Schlagworte:	Original contributions
Online Zugang:	https://nasplib.isofts.kiev.ua/handle/123456789/145373
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!
Назва журналу:	Digital Library of Periodicals of National Academy of Sciences of Ukraine
Zitieren:	Hypoxia enhances antitumor activity of dichloroacetate / D.L. Kolesnik, O.N. Pyaskovskaya, I.V. Boichuk, G.I. Solyanik // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 231-235. — Бібліогр.: 14 назв. — англ.

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