TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia
Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substit...
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| Published in: | Experimental Oncology |
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| Date: | 2014 |
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145384 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia / N.I. Bilous, I.V. Abramenko, A.A. Chumak, I.S. Dyagil, Z.V. Martina // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 258-261. — Бібліогр.: 30 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862729193039593472 |
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| author | Bilous, N.I. Abramenko, I.V. Chumak, A.A. Dyagil, I.S. Martina, Z.V. |
| author_facet | Bilous, N.I. Abramenko, I.V. Chumak, A.A. Dyagil, I.S. Martina, Z.V. |
| citation_txt | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia / N.I. Bilous, I.V. Abramenko, A.A. Chumak, I.S. Dyagil, Z.V. Martina // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 258-261. — Бібліогр.: 30 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substitution influencing apoptotic potential of TP53 protein. The aim of the study was to evaluate the association of the TP53 codon 72 polymorphism and incidence of TP53 mutations in CLL patients. Methods: 261 CLL samples were analyzed by polymerase chain reaction and direct sequencing for TP53 mutations and single nucleotide polymorphism. Results: The 72Pro/Pro genotype was associated with an increased incidence of TP53 mutations in previously treated patients (OR = 2.503; 95% CI 1.142–5.487; р = 0.001). Conclusion: This study revealed that the TP53 codon 72 polymorphism may be used as a risk factor for incidence of TP53 mutations in CLL. Key Words: chronic lymphocytic leukemia, TP53 mutations, single nucleotide polymorphism.
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| first_indexed | 2025-12-07T19:13:39Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-145384 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T19:13:39Z |
| publishDate | 2014 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Bilous, N.I. Abramenko, I.V. Chumak, A.A. Dyagil, I.S. Martina, Z.V. 2019-01-21T11:34:56Z 2019-01-21T11:34:56Z 2014 TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia / N.I. Bilous, I.V. Abramenko, A.A. Chumak, I.S. Dyagil, Z.V. Martina // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 258-261. — Бібліогр.: 30 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145384 Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substitution influencing apoptotic potential of TP53 protein. The aim of the study was to evaluate the association of the TP53 codon 72 polymorphism and incidence of TP53 mutations in CLL patients. Methods: 261 CLL samples were analyzed by polymerase chain reaction and direct sequencing for TP53 mutations and single nucleotide polymorphism. Results: The 72Pro/Pro genotype was associated with an increased incidence of TP53 mutations in previously treated patients (OR = 2.503; 95% CI 1.142–5.487; р = 0.001). Conclusion: This study revealed that the TP53 codon 72 polymorphism may be used as a risk factor for incidence of TP53 mutations in CLL. Key Words: chronic lymphocytic leukemia, TP53 mutations, single nucleotide polymorphism. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia Article published earlier |
| spellingShingle | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia Bilous, N.I. Abramenko, I.V. Chumak, A.A. Dyagil, I.S. Martina, Z.V. Original contributions |
| title | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| title_full | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| title_fullStr | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| title_full_unstemmed | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| title_short | TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| title_sort | tp53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145384 |
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