TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia

• Published in: Experimental Oncology
• Date: 2014
• Main Authors: Bilous, N.I., Abramenko, I.V., Chumak, A.A., Dyagil, I.S., Martina, Z.V.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2014
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145384
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: TP53 codon 72 single nucleotide polymorphism in chronic lymphocytic leukemia / N.I. Bilous, I.V. Abramenko, A.A. Chumak, I.S. Dyagil, Z.V. Martina // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 258-261. — Бібліогр.: 30 назв. — англ.

Defects in the tumor suppressor gene TP53 are known to be important in chronic lymphocytic leukemia (CLL) and TP53 inactivation is associated with a particularly aggressive form of the disease. The single nucleotide polymorphism in the TP53 gene at codon 72 (rs1042522), results in amino acid substit...