The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue
The aim of the present study was to evaluate the change of thymidine phosphorylase (TP) activity in gastric adenocarcinoma and adjacent tissue upon the intraarterial administration of 5-fluorouracil (5-FU). Matherials and methods: The specimens of tumor and adjacent tissue were obtained by surgical...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2014 |
| Автори: | , , , , |
| Формат: | Стаття |
| Мова: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2014
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145389 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue / M. Stashkevych, E. Khomutov, Y. Dumanskiy, A. Matviyenko, I. Zinkovych // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 267-270. — Бібліогр.: 17 назв. — англ. |
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nasplib_isofts_kiev_ua-123456789-145389 |
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Stashkevych, M. Khomutov, E. Dumanskiy, Y. Matviyenko, A. Zinkovych, I. 2019-01-21T11:48:43Z 2019-01-21T11:48:43Z 2014 The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue / M. Stashkevych, E. Khomutov, Y. Dumanskiy, A. Matviyenko, I. Zinkovych // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 267-270. — Бібліогр.: 17 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145389 The aim of the present study was to evaluate the change of thymidine phosphorylase (TP) activity in gastric adenocarcinoma and adjacent tissue upon the intraarterial administration of 5-fluorouracil (5-FU). Matherials and methods: The specimens of tumor and adjacent tissue were obtained by surgical operation on 36 patients (20 men and 16 women aged from 38 to 82 years) with gastric adenocarcinoma (stages II–IV). 5-FU was administered in the bolus dose to the gastroepiploic artery 2–60 min before the tumor resection. The concentration of 5-FU and activity of TP in both tissues were determined by high performance liquid chromatography method. Results: The concentration of 5-FU was decreased in a time-dependent manner in both tissues, though the interpatient variability of this value was much less in tumor tissue. The activity of TP was decreased with the course of the time after 5-FU administration in tumor and normal adjacent tissue. There were statistically significant differences in the TP activity in both tissues between 2–20 min and 40–60 min after 5-FU injection (p < 0.05). Conclusion: 5-FU administration results in the decrease of TP activity in tumor and normal adjacent tissues that might have importance for chemotherapy with fluoropyrimidines. Key Words: 5-fluorouracil, thymidine phosphorylase, gastric adenocarcinoma, normal mucosa. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| spellingShingle |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue Stashkevych, M. Khomutov, E. Dumanskiy, Y. Matviyenko, A. Zinkovych, I. Original contributions |
| title_short |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| title_full |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| title_fullStr |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| title_full_unstemmed |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| title_sort |
influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue |
| author |
Stashkevych, M. Khomutov, E. Dumanskiy, Y. Matviyenko, A. Zinkovych, I. |
| author_facet |
Stashkevych, M. Khomutov, E. Dumanskiy, Y. Matviyenko, A. Zinkovych, I. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2014 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
The aim of the present study was to evaluate the change of thymidine phosphorylase (TP) activity in gastric adenocarcinoma and adjacent tissue upon the intraarterial administration of 5-fluorouracil (5-FU). Matherials and methods: The specimens of tumor and adjacent tissue were obtained by surgical operation on 36 patients (20 men and 16 women aged from 38 to 82 years) with gastric adenocarcinoma (stages II–IV). 5-FU was administered in the bolus dose to the gastroepiploic artery 2–60 min before the tumor resection. The concentration of 5-FU and activity of TP in both tissues were determined by high performance liquid chromatography method. Results: The concentration of 5-FU was decreased in a time-dependent manner in both tissues, though the interpatient variability of this value was much less in tumor tissue. The activity of TP was decreased with the course of the time after 5-FU administration in tumor and normal adjacent tissue. There were statistically significant differences in the TP activity in both tissues between 2–20 min and 40–60 min after 5-FU injection (p < 0.05). Conclusion: 5-FU administration results in the decrease of TP activity in tumor and normal adjacent tissues that might have importance for chemotherapy with fluoropyrimidines. Key Words: 5-fluorouracil, thymidine phosphorylase, gastric adenocarcinoma, normal mucosa.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145389 |
| citation_txt |
The influence of 5-fluorouracil on activity of thymidine phosphorylase in gastric adenocarcinoma and normal adjacent tissue / M. Stashkevych, E. Khomutov, Y. Dumanskiy, A. Matviyenko, I. Zinkovych // Experimental Oncology. — 2014. — Т. 36, № 4. — С. 267-270. — Бібліогр.: 17 назв. — англ. |
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| first_indexed |
2025-11-28T05:19:42Z |
| last_indexed |
2025-11-28T05:19:42Z |
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