Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives

Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives

In recent years, the new direction such as identification of informative circulating markers reflecting molecular genetic changes in the DNA of tumor cells was actively developed. Smoking-related DNA adducts are very promising research area, since they indicate high pathogenetic importance in the lu...

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Published in:Experimental Oncology
Date:2015
Main Authors: Grigoryeva, E.S., Kokova, D.A., Gratchev, A.N., Cherdyntsev, E.S., Buldakov, M.A., Kzhyshkowska, J.G., Cherdyntseva, N.V.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
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Reviews
Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145391
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives / E.S. Grigoryeva, D.A. Kokova, A.N. Gratchev, E.S. Cherdyntsev, M.A. Buldakov, J.G. Kzhyshkowska, N.V. Cherdyntseva // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 5-12. — Бібліогр.: 74 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145391
record_format dspace
spelling Grigoryeva, E.S.
Kokova, D.A.
Gratchev, A.N.
Cherdyntsev, E.S.
Buldakov, M.A.
Kzhyshkowska, J.G.
Cherdyntseva, N.V.
2019-01-21T11:50:42Z
2019-01-21T11:50:42Z
2015
Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives / E.S. Grigoryeva, D.A. Kokova, A.N. Gratchev, E.S. Cherdyntsev, M.A. Buldakov, J.G. Kzhyshkowska, N.V. Cherdyntseva // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 5-12. — Бібліогр.: 74 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145391
In recent years, the new direction such as identification of informative circulating markers reflecting molecular genetic changes in the DNA of tumor cells was actively developed. Smoking-related DNA adducts are very promising research area, since they indicate high pathogenetic importance in the lung carcinogenesis and can be identified in biological samples with high accuracy and reliability using highly sensitive mass spectrometry methods (TOF/TOF, TOF/MS, MS/MS). The appearance of DNA adducts in blood or tissues is the result of the interaction of carcinogenic factors, such as tobacco constituents, and the body reaction which is determined by individual characteristics of metabolic and repair systems. So, DNA adducts may be considered as a cumulative mirror of heterogeneous response of different individuals to smoking carcinogens, which finally could determine the risk for lung cancer. This review is devoted to analysis of the role of DNA adducts in lung carcinogenesis in order to demonstrate their usefulness as cancer associated markers. Currently, there are some serious limitations impeding the widespread use of DNA adducts as cancer biomarkers, due to failure of standardization of mass spectrometry analysis in order to correctly measure the adduct level in each individual. However, it is known that all DNA adducts are immunogenic, their accumulation over some threshold concentration leads to the appearance of long-living autoantibodies. Thus, detection of an informative pattern of autoantibodies against DNA adducts using innovative multiplex ELISA immunoassay may be a promising approach to find lung cancer at an early stage in high-risk groups (smokers, manufacturing workers, urban dwellers). Key Words: lung cancer, DNA adducts, tobacco smoking.
This Research was supported by Federal Targeted Programme for Research and Development in Prio­rity Areas of Development of the Russian Scientific and Technological Complex for 2014–2020, “Development of molecular signatures for early detection of lung cancer” (№ 14.575.21.0064 from 05.08.2014).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Reviews
Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
spellingShingle Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
Grigoryeva, E.S.
Kokova, D.A.
Gratchev, A.N.
Cherdyntsev, E.S.
Buldakov, M.A.
Kzhyshkowska, J.G.
Cherdyntseva, N.V.
Reviews
title_short Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
title_full Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
title_fullStr Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
title_full_unstemmed Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives
title_sort smoking-related dna adducts as potential diagnostic markers of lung cancer: new perspectives
author Grigoryeva, E.S.
Kokova, D.A.
Gratchev, A.N.
Cherdyntsev, E.S.
Buldakov, M.A.
Kzhyshkowska, J.G.
Cherdyntseva, N.V.
author_facet Grigoryeva, E.S.
Kokova, D.A.
Gratchev, A.N.
Cherdyntsev, E.S.
Buldakov, M.A.
Kzhyshkowska, J.G.
Cherdyntseva, N.V.
topic Reviews
topic_facet Reviews
publishDate 2015
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description In recent years, the new direction such as identification of informative circulating markers reflecting molecular genetic changes in the DNA of tumor cells was actively developed. Smoking-related DNA adducts are very promising research area, since they indicate high pathogenetic importance in the lung carcinogenesis and can be identified in biological samples with high accuracy and reliability using highly sensitive mass spectrometry methods (TOF/TOF, TOF/MS, MS/MS). The appearance of DNA adducts in blood or tissues is the result of the interaction of carcinogenic factors, such as tobacco constituents, and the body reaction which is determined by individual characteristics of metabolic and repair systems. So, DNA adducts may be considered as a cumulative mirror of heterogeneous response of different individuals to smoking carcinogens, which finally could determine the risk for lung cancer. This review is devoted to analysis of the role of DNA adducts in lung carcinogenesis in order to demonstrate their usefulness as cancer associated markers. Currently, there are some serious limitations impeding the widespread use of DNA adducts as cancer biomarkers, due to failure of standardization of mass spectrometry analysis in order to correctly measure the adduct level in each individual. However, it is known that all DNA adducts are immunogenic, their accumulation over some threshold concentration leads to the appearance of long-living autoantibodies. Thus, detection of an informative pattern of autoantibodies against DNA adducts using innovative multiplex ELISA immunoassay may be a promising approach to find lung cancer at an early stage in high-risk groups (smokers, manufacturing workers, urban dwellers). Key Words: lung cancer, DNA adducts, tobacco smoking.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145391
citation_txt Smoking-related DNA adducts as potential diagnostic markers of lung cancer: new perspectives / E.S. Grigoryeva, D.A. Kokova, A.N. Gratchev, E.S. Cherdyntsev, M.A. Buldakov, J.G. Kzhyshkowska, N.V. Cherdyntseva // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 5-12. — Бібліогр.: 74 назв. — англ.
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first_indexed 2025-12-07T15:43:43Z
last_indexed 2025-12-07T15:43:43Z
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