In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents

• Published in: Experimental Oncology
• Date: 2015
• Main Authors: Sen, A., Goswami, K.K., Mallick, A., Saxena, A.K., Sanyal, U., Baral, R.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145450
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: In vitro and in vivo evaluation of 2-chloroethylnitrosourea derivatives as antitumor agents / A. Sen, K.K. Goswami, A. Mallick, A.K. Saxena, U. Sanyal, R. Baral // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 23-29. — Бібліогр.: 19 назв. — англ.

Aim: To evaluate potential of Naphthal-NU, Napro-NU and 5-Nitro-naphthal-NU, 2-chloroethylnitrosourea compounds with substituted naphthalimide in the pre-clinical studies. Materials and Methods: In vitro cytotoxicity of three nitrosoureas was determined in human and mouse tumor cell lines by MTT ass...