CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome

Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45...

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Published in:Experimental Oncology
Date:2015
Main Authors: Osinsky, S., Kovelskaya, A., Bubnovskaya, L., Osinsky, D., Merentsev, S.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145455
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145455
record_format dspace
spelling Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
2019-01-21T21:27:43Z
2019-01-21T21:27:43Z
2015
CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145455
Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thoroughly informed about the study that was approved by the local ethics committee. Statistical analyses were done using NCSS2000/PASS2000 and Prism, version 4.03 software packages. Results: It was detected that 80.5 and 81.3% of patients had CD8- and CD45RO-positive T cells in BM, respectively. When DTCs were detected in BM, the number of patients with CD8-and CD45RO-positive T cells in BM were 86.1 and 84.4%, respectively. It was also determined that the number of patients with DTCs in BM with categories M0 and M1 and with CD8- and CD45RO-positive T cells in BM were 86.2 and 85.7%, 85.7 and 80.0%, respectively. The association between DTCs in BM and presence of CD8 and CD45RO T cells lymphocytes in BM was not found. At the same time it was shown the association between presence of CD8 and CD45RO T lymphocytes and survival. The presence of CD8- and CD45RO-positive T cells in BM were accompanied with significantly longer overall survival of patients compared to that of patients without CD8- and CD45RO-positive T cells in BM. Conclusion: Patients with the presence of CD8- and CD45RO-posi­tive T cells in BM demonstrated better survival of GC patients than those with the absence of these cells in BM. It may be suggested that tumor cells in BM are controlled in a dormant state by T cells in BM, in particular by CD8-positive T cells. Key Words: CD8 T lymphocytes, CD45RO T lymphocytes, bone marrow, disseminated tumor cells, tumor hypoxia, survival.
This research was supported by the ­National Aca­demy of Sciences of Ukraine (Grants no. 0102U003228).
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
spellingShingle CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
Original contributions
title_short CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_full CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_fullStr CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_full_unstemmed CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
title_sort cd8 and cd45ro t lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome
author Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
author_facet Osinsky, S.
Kovelskaya, A.
Bubnovskaya, L.
Osinsky, D.
Merentsev, S.
topic Original contributions
topic_facet Original contributions
publishDate 2015
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To evaluate the association between the presence of CD8 and CD45RO T lymphocytes in bone marrow (BM), disseminated tumor cells (DTCs), tumor hypoxia and their impact on disease outcome. Material and methods: 91 naïve gastric cancer (GC) patients were enrolled into the study. DTCs, CD8- and CD45RO-positive T lymphocytes in BM were detected using immunocytochemistry. All patients were thoroughly informed about the study that was approved by the local ethics committee. Statistical analyses were done using NCSS2000/PASS2000 and Prism, version 4.03 software packages. Results: It was detected that 80.5 and 81.3% of patients had CD8- and CD45RO-positive T cells in BM, respectively. When DTCs were detected in BM, the number of patients with CD8-and CD45RO-positive T cells in BM were 86.1 and 84.4%, respectively. It was also determined that the number of patients with DTCs in BM with categories M0 and M1 and with CD8- and CD45RO-positive T cells in BM were 86.2 and 85.7%, 85.7 and 80.0%, respectively. The association between DTCs in BM and presence of CD8 and CD45RO T cells lymphocytes in BM was not found. At the same time it was shown the association between presence of CD8 and CD45RO T lymphocytes and survival. The presence of CD8- and CD45RO-positive T cells in BM were accompanied with significantly longer overall survival of patients compared to that of patients without CD8- and CD45RO-positive T cells in BM. Conclusion: Patients with the presence of CD8- and CD45RO-posi­tive T cells in BM demonstrated better survival of GC patients than those with the absence of these cells in BM. It may be suggested that tumor cells in BM are controlled in a dormant state by T cells in BM, in particular by CD8-positive T cells. Key Words: CD8 T lymphocytes, CD45RO T lymphocytes, bone marrow, disseminated tumor cells, tumor hypoxia, survival.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145455
citation_txt CD8 and CD45RO T lymphocytes in bone marrow of gastric cancer patients: correlation with disseminated tumor cells and disease outcome / S. Osinsky, A. Kovelskaya, L. Bubnovskaya, D. Osinsky, S. Merentsev // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 48-52. — Бібліогр.: 27 назв. — англ.
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AT bubnovskayal cd8andcd45rotlymphocytesinbonemarrowofgastriccancerpatientscorrelationwithdisseminatedtumorcellsanddiseaseoutcome
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first_indexed 2025-12-07T18:34:31Z
last_indexed 2025-12-07T18:34:31Z
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