Functional activity of CD34-positive cells in chronic myeloid leukemia patients with different response to imatinib therapy

• Veröffentlicht in: Experimental Oncology
• Datum: 2015
• Hauptverfasser: Sviezhentseva, I.O., Perekhrestenko, T.P., Bilko, D.I., Gordienko, A.I., Diachenko, M.V., Dyagil, I.S.
• Format: Artikel
• Sprache: Englisch
• Veröffentlicht: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Schlagworte: Original contributions
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/145458
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Functional activity of CD34-positive cells in chronic myeloid leukemia patients with different response to imatinib therapy / I.O. Sviezhentseva, T.P. Perekhrestenko, D.I. Bilko, A.I. Gordienko, M.V. Diachenko, I.S. Dyagil // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 70-72. — Бібліогр.: 17 назв. — англ.

Introduction: It is believed that the reason of the leukemic clone cell resistance to treatment with tyrosine kinase inhibitors during chronic myeloid leukemia (CML) is mutations in the genome of an early bone marrow progenitor cells that are CD34-positive. Such cells, regardless of treatment, acqui...