Functional activity of CD34-positive cells in chronic myeloid leukemia patients with different response to imatinib therapy

• Published in: Experimental Oncology
• Date: 2015
• Main Authors: Sviezhentseva, I.O., Perekhrestenko, T.P., Bilko, D.I., Gordienko, A.I., Diachenko, M.V., Dyagil, I.S.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145458
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Functional activity of CD34-positive cells in chronic myeloid leukemia patients with different response to imatinib therapy / I.O. Sviezhentseva, T.P. Perekhrestenko, D.I. Bilko, A.I. Gordienko, M.V. Diachenko, I.S. Dyagil // Experimental Oncology. — 2015. — Т. 37, № 1. — С. 70-72. — Бібліогр.: 17 назв. — англ.

Introduction: It is believed that the reason of the leukemic clone cell resistance to treatment with tyrosine kinase inhibitors during chronic myeloid leukemia (CML) is mutations in the genome of an early bone marrow progenitor cells that are CD34-positive. Such cells, regardless of treatment, acqui...