Effect of dichloroacetate on Lewis lung carcinoma growth and metastasis

• Published in: Experimental Oncology
• Date: 2015
• Main Authors: Kolesnik, D.L., Pyaskovskaya, O.N., Boychuk, I.V., Dasyukevich, O.I., Melnikov, O.R., Tarasov, A.S., Solyanik, G.I.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145468
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Effect of dichloroacetate on Lewis lung carcinoma growth and metastasis / D.L. Kolesnik, O.N. Pyaskovskaya, I.V. Boychuk, O.I. Dasyukevich, O.R. Melnikov, A.S. Tarasov, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 126-129. — Бібліогр.: 16 назв. — англ.

A hallmark of malignancy is excessive tumor glycolysis, even in the presence of oxygen, which causes lactacidosis in the tumor microenvironment and favors tumor cell proliferation and survival. For this reason antimetabolic agents which target tumor cell metabolism are being researched extensively a...