Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor
Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. St...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2015 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
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| Zitieren: | Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ. |
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Shevchuk, O.O. Posokhova, K.A. Todor, I.N. Lukianova, N.Yu. Nikolaev, V.G. Chekhun, V.F. 2019-01-22T11:35:19Z 2019-01-22T11:35:19Z 2015 Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145469 Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and Methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous administration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy. Key Words: myelotoxicity, melphalan, enterosorption, granulocyte colony-stimulating factor. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor Article published earlier |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine |
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| title |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| spellingShingle |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor Shevchuk, O.O. Posokhova, K.A. Todor, I.N. Lukianova, N.Yu. Nikolaev, V.G. Chekhun, V.F. Original contributions |
| title_short |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| title_full |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| title_fullStr |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| title_full_unstemmed |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| title_sort |
prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor |
| author |
Shevchuk, O.O. Posokhova, K.A. Todor, I.N. Lukianova, N.Yu. Nikolaev, V.G. Chekhun, V.F. |
| author_facet |
Shevchuk, O.O. Posokhova, K.A. Todor, I.N. Lukianova, N.Yu. Nikolaev, V.G. Chekhun, V.F. |
| topic |
Original contributions |
| topic_facet |
Original contributions |
| publishDate |
2015 |
| language |
English |
| container_title |
Experimental Oncology |
| publisher |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| format |
Article |
| description |
Hematotoxicity and its complication are the prominent limiting factors for rational treatment of malignancies. Granulocyte colony-stimulating factor (G-CSF) is used to increase granulocyte production. It has been shown previously that enterosorption causes prominent myeloprotective activity also. Still, no trial was performed to combine both of them. Aim: To study the influence of combination of enterosorption and pharmaceutical analogue of naturally occurring G-CSF (filgrastim) on bone marrow protection and the growth of grafted tumor in a case of injection of melphalan (Mel). Materials and Methods: Mel injections were used for promotion of bone marrow suppression in rats. Carbon granulated enterosorbent C2 (IEPOR) was used for providing of enteral sorption detoxifying therapy. Filgrastim was used to increase white blood cells (WBC) count. Results: The simultaneous usage of enterosorption and filgrastim had maximum effectiveness for restoring of all types of blood cells. WBC count was higher by 138.3% compared with the Mel group. The increase of platelets count by 98.5% was also observed. In the group (Mel + C2 + filgrastim) the absolute neutrophils count was twofold higher, in comparison with rats of Mel group. Conclusion: Simultaneous administration of G-CSF-analogue and carbonic enterosorbent C2 is a perspective approach for bone marrow protection, when the cytostatic drug melphalan is used. Such combination demonstrates prominent positive impact on restoring of all types of blood cells and had no influence on the antitumor efficacy. Key Words: myelotoxicity, melphalan, enterosorption, granulocyte colony-stimulating factor.
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| issn |
1812-9269 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/145469 |
| citation_txt |
Prevention of myelosuppression by combined treatment with enterosorbent and granulocyte colony-stimulating factor / O.O. Shevchuk, K.A. Posokhova, I.N. Todor, N.Yu. Lukianova, V.G. Nikolaev, V.F. Chekhun // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 135-138. — Бібліогр.: 26 назв. — англ. |
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2025-12-02T04:26:52Z |
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