Paraganglioma-like dermal melanocytic tumor: a rare skin lesion
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2015 |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Zitieren: | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion / D.A. Zinovkin, V.S. Aliaksinski, A.K. Hryb, S.Yu. Dedik // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 156-157. — Бібліогр.: 3 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1860022345092038656 |
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| author | Zinovkin, D.A. Aliaksinski, V.S. Hryb, A.K. Dedik, S.Yu. |
| author_facet | Zinovkin, D.A. Aliaksinski, V.S. Hryb, A.K. Dedik, S.Yu. |
| citation_txt | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion / D.A. Zinovkin, V.S. Aliaksinski, A.K. Hryb, S.Yu. Dedik // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 156-157. — Бібліогр.: 3 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| first_indexed | 2025-12-07T16:48:00Z |
| format | Article |
| fulltext |
156 Experimental Oncology 37, 156–157, 2015 (June)
PARAGANGLIOMA-LIKE DERMAL MELANOCYTIC TUMOR:
A RARE SKIN LESION
D.A. Zinovkin1*, V.S. Aliaksinski2, A.K. Hryb2, S.Yu. Dedik3
1Department of Pathology, Republican Research Center for Radiation Medicine and Human Ecology,
Gomel 246040, Belarus
2Department of Pathology, Grodno State Medical University, Grodno 230009, Belarus
3Department of Pathology, Belarusian State Medical University, Minsk 220116, Belarus
Paraganglioma-like dermal melanocytic tumor
(PDMT) is a very rare dermal nodule, which resembles
clear cell sarcoma and skin melanoma in its morpho-
logy. Nowadays about 10 cases of the tumor are de-
scribed in world literature [1–3].
A 53-year old female patient visited her physician
and complained of a dermal nodule on her left thigh.
The nodule caused neither discomfort nor pain. Medi-
cal history showed that the tumor had existed since
her childhood. On physical examination, there was
pigmented nodule about 1.2 cm in diameter, located
on a left thigh. The lesion was surgically excised with vi-
sually clear margins. Grossly specimen was presented
with a pigmented nodule 1.2 cm in diameter not related
to the underlying fascia or ligaments (Fig. 1, a).
Tumor cells did not contain melanin, did not show
epidermotropism and were not connected with con-
nective tissue (Fig. 1, b). Microscopically nodule
showed nest-like growth pattern (Fig. 1, c), resembling
paraganglioma and consisted of clear oval cells slightly
Submitted: March 16, 2015.
*Correspondence: Tel.: +375291827416
E-mail: zinych007@yandex.ru
Abbreviations used: PDMT — paraganglioma-like dermal melanocytic tumor.
Exp Oncol 2015
37, 2, 156–157
LETTER TO EDITOR
a b
c d
Fig. 1. Microscopic investigation of nodule: a — dermal nodule (haematoxylin and eosin, original magnification × 4); b — absence of epidermal
junction (haematoxylin and eosin, original magnification × 100); c — nest-like growth pattern (haematoxylin and eosin, original magnifica-
tion × 200); d — paraganglioma-like clear oval cells with mild atypia (haematoxylin and eosin, original magnification × 1000, oil immersion)
Experimental Oncology 37, 156–157, 2015 (June) 157
divided by delicate fibrous strands. Less than 1 mitotic
figure was detected at × 40 magnification per 10 fields
of vision. For skin contains melanocytes, peripheral
nerve fibers, and no ganglions, development of para-
ganglioma of the skin is unlikely. Mild nuclear atypia
(Fig. 1, d) and absence of necroses were observed.
Immunohistochemical staining with HMB45 anti-
bodies showed membranous staining (Fig. 2, a). Melan
A staining was negative. Protein S100 showed strong
cytoplasmic in all tumor cells (Fig. 2, b). CD34 was
expressed only within vascular endothelium. Expres-
sion of SMA and vimentin in tumor stroma and its cells
were negative. Concluding all the clinicopathological
data we diagnosed the patient with PDMT.
In our opinion, PDMT is a benign dermal tumor. De-
spite the fact, that American Forces Institute of Pathology
considers it as a tumor of uncertain malignant potential
the studies show no relapses or metastasi zing of the
tumor. It is important to note, that PDMT can be mis-
taken for such malignant tumors as clear cell sarcoma
and melanoma [1]. But differential diagnostics of these
malignant tumors can be easily performed during the
routine hematoxylin and eosin stain. Melanoma is char-
acterized by significant nuclear atypia, high mitotic ac-
tivity, epidermotropism and absence of nesting pattern,
which is inconsistent with PDMT. Clear cell sarcoma
is characterized by prominent nucleoli, high mitotic
activity, scattered giant tumor cells [2]. We are inclined
to think that for more accurate diagnosis of PDMT an im-
munohistochemical study with Melan A, HMB45, S100,
CD34, Desmin, SMA antibodies is necessary. Moreover,
PDMT may histopathologically resemble a solid variant
of glomus tumor, which sometimes can also be located
on lower limbs and have a nesting pattern and mild atypia.
Unlike PDMT, glomus tumor has large vessels and posi-
tive staining with CD34. Differential diagnostics of this
rare benign tumor with melanoma and clear cell sarcoma
require increased attention during histopathological
study, because mistake can further lead to the wrong
highly unnecessary treatment [3].
REFERENCES
1. Weedon D. Weedon’s Skin Pathology. 3rd ed. Lon-
don: Churchill Livingstone Elsevier, 2010. 1041 p.
2. Deyrup AT, Althof P, Zhou M, et al. Paraganglioma-like
dermal melanocytic tumor: a unique entity distinct from cel-
lular blue nevus, clear cell sarcoma, and cutaneous melanoma.
Am J Surg Pathol 2004; 28: 1579–86.
3. Cimpean AM, Ceauşu R, Raica M. Paraganglioma-
like dermal melanocytic tumor: a case report with particular
features. Int J Clin Exp Pathol 2010; 3: 222–5.
Copyright © Experimental Oncology, 2015
a b
Fig. 2. Immunohistochemical analysis: a — cells are positive for HMB45 (DAB, original magnification × 200); b — cells are positive
for S100 (DAB, original magnification × 200)
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| id | nasplib_isofts_kiev_ua-123456789-145474 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T16:48:00Z |
| publishDate | 2015 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Zinovkin, D.A. Aliaksinski, V.S. Hryb, A.K. Dedik, S.Yu. 2019-01-22T11:45:48Z 2019-01-22T11:45:48Z 2015 Paraganglioma-like dermal melanocytic tumor: a rare skin lesion / D.A. Zinovkin, V.S. Aliaksinski, A.K. Hryb, S.Yu. Dedik // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 156-157. — Бібліогр.: 3 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145474 en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Letter to editor Paraganglioma-like dermal melanocytic tumor: a rare skin lesion Article published earlier |
| spellingShingle | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion Zinovkin, D.A. Aliaksinski, V.S. Hryb, A.K. Dedik, S.Yu. Letter to editor |
| title | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| title_full | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| title_fullStr | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| title_full_unstemmed | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| title_short | Paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| title_sort | paraganglioma-like dermal melanocytic tumor: a rare skin lesion |
| topic | Letter to editor |
| topic_facet | Letter to editor |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145474 |
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