Sergiy Petrovych Osinsky (1945–2015)
Professor Sergiy Petrovych Osinsky, an outstanding
 scientist, oncologist and pathophysiologist, Head
 of Department of the Microenvironment of Tumor Cells
 of the R.E. Kavetsky Institute of Experimental Pathology,
 Oncology and Radiobiology (IEPOR) of the NAS
...
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| Veröffentlicht in: | Experimental Oncology |
|---|---|
| Datum: | 2015 |
| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Zitieren: | Sergiy Petrovych Osinsky (1945–2015) // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 159-160. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1860090735532965888 |
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| citation_txt | Sergiy Petrovych Osinsky (1945–2015) // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 159-160. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Professor Sergiy Petrovych Osinsky, an outstanding
scientist, oncologist and pathophysiologist, Head
of Department of the Microenvironment of Tumor Cells
of the R.E. Kavetsky Institute of Experimental Pathology,
Oncology and Radiobiology (IEPOR) of the NAS
of Ukraine, died on May 21, 2015, at the age of 69.
|
| first_indexed | 2025-12-07T17:23:13Z |
| format | Article |
| fulltext |
Experimental Oncology 37, 159–160, 2015 (June) 159
SERGIY PETROVYCH OSINSKY
(1945‒2015)
Professor Sergiy Petrovych Osinsky, an outstanding
scientist, oncologist and pathophysiologist, Head
of Department of the Microenvironment of Tumor Cells
of the R.E. Kavetsky Institute of Experimental Patho-
logy, Oncology and Radiobiology (IEPOR) of the NAS
of Ukraine, died on May 21, 2015, at the age of 69.
Sergiy Osinsky was born in Mytischy, Moscow
region, in the family of doctor. Studying at O.O. Bogo-
molets Medical Institute in Kyiv, Dr. Osinsky started his
research activity at the Institute of Experimental and
Clinical Oncology of the Ministry of Health of Ukraine
and he adhered to this Institute (now — R.E. Kavetsky
IEPOR of the NAS of Ukraine) to the end of his life.
In 1973, after his post-graduation study, Dr. Osinsky
successfully defended his Ph.D. thesis “Influence
of oestrogentherapy on the some indices of metabo-
lism in 7.12-DMBA induced mammary tumors in rats”.
In 1987, he defended the doctoral thesis “Background
of application of induced hyperglycemia for enhance-
ment of anticancer efficacy of chemotherapy and hy-
perthermia”. In 1977–1984, Dr. Osinsky worked as a sci-
entific secretary of R.E. Kavetsky IEPOR of the NAS
of Ukraine. In 1993, he was awarded the aca demic title
of professor by the speciality “Onco logy”.
In 1980 and 1984, Dr. Osinsky worked at Manfred
von Ardenne Research Institute (Dresden, DDR).
In 1991 and 1993, he had the chance to work in the De-
partment of Pathophysiology headed by Professor
Peter Vaupel at the Institute of Physiology and Patho-
physiology at the Johannes Gutenberg University
of Mainz (Germany). In 2002, he was invited as a Guest
Professor to the University La Sapienza (Rome, Italy)
in the Department of Chemistry headed by Professor
Luigi Campanella.
Prof. Sergiy Osinsky was a scientist with well-es-
tablished international reputation in the field of tumor
pathophysiology. His main areas of interest concerned
tumor hypoxia and pH-dependent anticancer modali-
ties, both of which are well known to be important fac-
tors in determining tumor response to therapy. He was
active in finding clinically applicable methods for modi-
fying tumor microphysiology to enhance the efficacy
of subsequent anti-tumor treatment, that is timely,
innovative and of interest to the scientific community.
Prof. Osinsky demonstrated that the response
of tumors to radiation, chemotherapy or hyperthermia
could be enhanced using organocobalt complexes, ra-
diosensitizers like AK-2123 or nicotinamide, inhibitors
of DNA repair or cryotreatment. His greatest impact
in research was in modifying tumor pH to improve
the therapy outcome. Prof. Osinsky clearly demon-
strated that tumor pH could be decreased by hyper-
glycemia, either when given alone or when combined
with other modalities. With such a decrease in pH, the
tumors are sensitized to chemotherapy and/or hyper-
thermia. The results from his experimental studies
have been successfully translated into clinical practice
leading to significant improvements in patient survival.
Prof. Osinsky’s research activity addressed a num-
ber of clinically relevant problems in which appropriate
experimental techniques have been used to gain in-
sights into ways in which these problems might be re-
solved. Together with Prof. Valentyn Ganul, he was
the first who initiated the application of microwave
hyperthermia in the combined treatment of cancer
patients in Ukraine. Prof. Osinsky improved the use
of hyperthermia modality in the clinical practice.
In recognition of his achievements, he was elected
as a member of Consensus Group in Hyperthermia
at Kadota Forum (Osaka, June 2004).
Prof. Osinsky was among the few people who could
claim that his research is truly translational. His latest
research activity was focused on the role of hypoxia
in malignant progression, in particular in gastric and
pancreatic cancer, the evaluation of significance
of hypoxia-regulated proteins as prognostic factors for
clinical outcome, and the detection of disseminated
cancer cells in peripheral blood and bone marrow
in relation to the hypoxic profile of tumors. His studies
were supported by the number of international grants
(INTAS, SNSF “SCOPES”, STCU) and were coordi-
nated by several European research centers.
Prof. Osinsky authored more than 250 scien-
tific papers and 6 monographs, namely “Hyperther-
mia and hyperglycemia in oncology” (coauthored
with E.A. Zhavrid, S.Z. Fradkin, 1987), “Thermo-
physical models of tumors hyperthermia” (coau-
thored with A.N. Gusev, V.L. Sigal, 1989), “Tumor cells
in peripheral blood and bone marrow of patients with
malignant tumors” (coauthored with D.F. Gluzman,
V.A. Chernyi, V.V. Lukianchuk, D.S. Osinsky, 2005),
“Molecular tumor diagnostics: fundamental bases and
Exp Oncol 2015
37, 2, 159–160
160 Experimental Oncology 37, 159–160, 2015 (June)
practical use” (coauthored with D.F. Gluzman, J. Kliff,
N.A. Gise, G. Friss, 2007), “Tumor microphysiology”
(coauthored with P. Vaupel, 2009), “Tumor hypoxia
in the clinical setting” (coeditors H. Friess, P. Vaupel,
2011). He had eight patents for the inventions.
Prof. Osinsky presented his results in many
Ukrainian and International scientific meetings, with
65 abstracts having been published in the proceedings
of various International scientific forums.
Sergiy Osinsky was a member of several profes-
sional societies: International Clinical Hyperthermia So-
ciety (ICHS), Indianapolis, USA (a member of the Board
of Directors since 1988); European Society of Hyper-
thermic Oncology (ESHO), Rotterdam, the Netherland
(a member of the Board since 2005); British Associa-
tion of Cancer Research (BACR) since 2003; European
Association of Cancer Research (EACR) since 2004.
Prof. Osinsky was a President of the 18th Interna-
tional Symposium of ICHS in 1995 (Kyiv), a Chair-
man of the International Workshop on applying
of hyperthermia as modifying agent in the treatment
of cancer patients in 1997 (Kyiv), and Vice-Chairman
of the INTAS Workshop “Interdisciplinary Approaches
for Cancer Treatment” in 2000 (Kyiv).
Prof. Osinsky was the first winner of R.E. Kavetsky
Award of the NAS of Ukraine in 2001.
He served as a Deputy-Editor-in-Chief of “Ex-
perimental Oncology” international journal, a mem-
ber of Editorial Board of “Oncology” journal and
Vice-Chairman in the Specialized Council for Thesis
Defense D 26.155.01 on speciality “Oncology” (Kyiv).
All those who had the opportunity to work and
communicate with Sergiy Osinsky knew him as a ta-
lented creative scientist with a wide range of interests,
an intellectual, a fellow capable of listening and un-
derstanding the others, being ready to help in a timely
manner, a person of the broadest erudition, exception-
al honesty and integrity. All the life of Sergiy Osinsky
was entirely devo ted to selfless service to science,
constant search for ways to solve complex problems
of oncology. He can rightly be reckoned among those
talented scientists who developed the basic ideas
of Bogomolets — Kavetsky School of thoughts. Sergiy
Petrovych belonged to the category of lucky persons,
whose whole life was devoted to the favorite lifework
and who had the right to say: “I did everything I could,
let others do better”. The bright memory of Sergiy
Petrovych Osinsky will remain forever in the hearts
of all who knew him.
Administration and team
of the R.E. Kavetsky Institute of Experimental
Pathology, Oncology and Radiobiology
of the NAS of Ukraine
Editorial Board of “Experimental Oncology”
Copyright © Experimental Oncology, 2015
|
| id | nasplib_isofts_kiev_ua-123456789-145476 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T17:23:13Z |
| publishDate | 2015 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | 2019-01-22T11:49:40Z 2019-01-22T11:49:40Z 2015 Sergiy Petrovych Osinsky (1945–2015) // Experimental Oncology. — 2015. — Т. 37, № 2. — С. 159-160. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145476 Professor Sergiy Petrovych Osinsky, an outstanding
 scientist, oncologist and pathophysiologist, Head
 of Department of the Microenvironment of Tumor Cells
 of the R.E. Kavetsky Institute of Experimental Pathology,
 Oncology and Radiobiology (IEPOR) of the NAS
 of Ukraine, died on May 21, 2015, at the age of 69. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Obituary Sergiy Petrovych Osinsky (1945–2015) Article published earlier |
| spellingShingle | Sergiy Petrovych Osinsky (1945–2015) Obituary |
| title | Sergiy Petrovych Osinsky (1945–2015) |
| title_full | Sergiy Petrovych Osinsky (1945–2015) |
| title_fullStr | Sergiy Petrovych Osinsky (1945–2015) |
| title_full_unstemmed | Sergiy Petrovych Osinsky (1945–2015) |
| title_short | Sergiy Petrovych Osinsky (1945–2015) |
| title_sort | sergiy petrovych osinsky (1945–2015) |
| topic | Obituary |
| topic_facet | Obituary |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145476 |