Hormonal impact on tumor growth and progression
In this review, current knowledge of hormones impact on prostate, breast and endometrium cancer growth and transition to hormone therapy resistant phenotype is summarized. A special consideration is given to genetic alterations and hormone responsive signaling pathways. Estrogen, androgen and proge...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2015 |
| ISSN: | 1812-9269 |
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| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Schlagworte: | |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/145483 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Hormonal impact on tumor growth and progression / A. Reznikov // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 162-172. — Бібліогр.: 112 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | In this review, current knowledge of hormones impact on prostate, breast and endometrium cancer growth and transition to hormone therapy resistant phenotype is summarized. A special consideration is given to genetic alterations and hormone responsive signaling pathways. Estrogen, androgen and progesterone are the key drivers in these cancer variants. Hormone receptors and their interplay with plenty of growth factors generated by the tumor microenvironment contribute greatly to carcinogenesis and cancer cell proliferation. The tumor cell plasticity that could explain a loss of responsiveness to hormone deprivation therapy and aggressive course of the diseases has been addressed. Key Words: hormone, prostate cancer, breast cancer, endometrial cancer, receptor signaling.
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| ISSN: | 1812-9269 |