Enhanced cytotoxicity of рhotoexcited fullerene C60 and cisplatin combination against drug-resistant leukemic cells

• Published in: Experimental Oncology
• Date: 2015
• Main Authors: Franskevych, D.V., Prylutska, S.V., Grynyuk, I.I., Grebinyk, D.M., Matyshevska, O.P.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145486
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Enhanced cytotoxicity of рhotoexcited fullerene C60 and cisplatin combination against drug-resistant leukemic cells / D.V. Franskevych, S.V. Prylutska, I.I. Grynyuk, D.M. Grebinyk, O.P. Matyshevska // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 187-191. — Бібліогр.: 34 назв. — англ.

Aim: To evaluate the viability of leukemic cells sensitive (L1210S) and resistant (L1210R) to cisplatin, ROS production and free cytosolic Ca²⁺ concentration under treatment with cisplatin or its combination with photoexcited fullerene C₆₀. Methods: Cell viability was assessed by the MTT reduction a...