Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules

Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules

The aim: To evaluate anticancer activity of vaccination with chicken embryo proteins (CEP) applied in different schedules. Materials and Methods: C57Bl mice were vaccinated with CEP before (prophylactic schedule) or after (different therapeutic schedules with or without preliminary tumor removal) th...

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Published in:Experimental Oncology
Date:2015
Main Authors: Symchych, T.V., Fedosova, N.I., Karaman, O.M., Yevstratieva, L.M., Lisovenko, H.S., Voyeykova, I.M., Potebnia, H.P.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145488
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules / T.V. Symchych, N.I. Fedosova, O.M. Karaman, L.M. Yevstratieva, H.S. Lisovenko, I.M. Voyeykova, H.P. Potebnia // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 197-202. — Бібліогр.: 35 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145488
record_format dspace
spelling Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Lisovenko, H.S.
Voyeykova, I.M.
Potebnia, H.P.
2019-01-22T12:58:10Z
2019-01-22T12:58:10Z
2015
Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules / T.V. Symchych, N.I. Fedosova, O.M. Karaman, L.M. Yevstratieva, H.S. Lisovenko, I.M. Voyeykova, H.P. Potebnia // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 197-202. — Бібліогр.: 35 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145488
The aim: To evaluate anticancer activity of vaccination with chicken embryo proteins (CEP) applied in different schedules. Materials and Methods: C57Bl mice were vaccinated with CEP before (prophylactic schedule) or after (different therapeutic schedules with or without preliminary tumor removal) the Lewis lung carcinoma cells transplantation. The latent period of tumor development, tumor volume and metastasis rate were evaluated. Results: Potent antimetastatic effect of CEP-based vaccination was seen in case of therapeutic regimen after primary tumor removal. The metastasis inhibition index (MII) reached 96.9 and 97.8% on 18th and 34th day after tumor removal, respectively. When CEP vaccination was performed in the settings of therapeutic regimen without primary tumor removal the anticancer effect was evident only if vaccinations started as early as 24 h after the cancer cells injections. The highest MII achieved in such condition was 77.6%, tumor volume in the group of vaccinated animals was by 53.1–42.1% lower than in the control tumor-bearing mice. CEP vaccination before tumor challenge (prophylactic immunization) led to a statistically significant prolongation of the latent period of tumor development, a reduction of tumor volume (35.8–48.8% compared to control unvaccinated mice) and a marked inhibition of metastasis (MII was 71.1%). Conclusion: Vaccination based on CEP exhibited both prophylactic and therapeutic anticancer effects. The last one is more pronounced when the vaccination starts shortly after the primary tumor resection. Key Words: chicken embryo proteins, anticancer activity, Lewis lung carcinoma.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
spellingShingle Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Lisovenko, H.S.
Voyeykova, I.M.
Potebnia, H.P.
Original contributions
title_short Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
title_full Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
title_fullStr Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
title_full_unstemmed Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
title_sort anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules
author Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Lisovenko, H.S.
Voyeykova, I.M.
Potebnia, H.P.
author_facet Symchych, T.V.
Fedosova, N.I.
Karaman, O.M.
Yevstratieva, L.M.
Lisovenko, H.S.
Voyeykova, I.M.
Potebnia, H.P.
topic Original contributions
topic_facet Original contributions
publishDate 2015
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description The aim: To evaluate anticancer activity of vaccination with chicken embryo proteins (CEP) applied in different schedules. Materials and Methods: C57Bl mice were vaccinated with CEP before (prophylactic schedule) or after (different therapeutic schedules with or without preliminary tumor removal) the Lewis lung carcinoma cells transplantation. The latent period of tumor development, tumor volume and metastasis rate were evaluated. Results: Potent antimetastatic effect of CEP-based vaccination was seen in case of therapeutic regimen after primary tumor removal. The metastasis inhibition index (MII) reached 96.9 and 97.8% on 18th and 34th day after tumor removal, respectively. When CEP vaccination was performed in the settings of therapeutic regimen without primary tumor removal the anticancer effect was evident only if vaccinations started as early as 24 h after the cancer cells injections. The highest MII achieved in such condition was 77.6%, tumor volume in the group of vaccinated animals was by 53.1–42.1% lower than in the control tumor-bearing mice. CEP vaccination before tumor challenge (prophylactic immunization) led to a statistically significant prolongation of the latent period of tumor development, a reduction of tumor volume (35.8–48.8% compared to control unvaccinated mice) and a marked inhibition of metastasis (MII was 71.1%). Conclusion: Vaccination based on CEP exhibited both prophylactic and therapeutic anticancer effects. The last one is more pronounced when the vaccination starts shortly after the primary tumor resection. Key Words: chicken embryo proteins, anticancer activity, Lewis lung carcinoma.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145488
citation_txt Anticancer effectiveness of vaccination based on xenogeneic embryo proteins applied in different schedules / T.V. Symchych, N.I. Fedosova, O.M. Karaman, L.M. Yevstratieva, H.S. Lisovenko, I.M. Voyeykova, H.P. Potebnia // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 197-202. — Бібліогр.: 35 назв. — англ.
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AT yevstratievalm anticancereffectivenessofvaccinationbasedonxenogeneicembryoproteinsappliedindifferentschedules
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first_indexed 2025-12-07T16:36:07Z
last_indexed 2025-12-07T16:36:07Z
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