TRP genes family expression in colorectal cancer
Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract. Different factors are responsible for the development of CRC. Transient Receptor Potential (TRP) which is an important component of calcium channel is associated with several pathological conditions like cancer, neurode...
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| Published in: | Experimental Oncology |
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| Date: | 2015 |
| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145490 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | TRP genes family expression in colorectal cancer / Y. Sozucan, M.E. Kalender, I. Sari, A. Suner, S. Oztuzcu, K. Arman, O. Yumrutas, I. Bozgeyik, B. Cengiz, Y.Z. Igci, O. Balakan, C. Camci // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 208-212. — Бібліогр.: 31 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862557656508530688 |
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| author | Sozucan, Y. Kalender, M.E. Sari, I. Suner, A. Oztuzcu, S. Arman, K. Yumrutas, O. Bozgeyik, I. Cengiz, B. Balakan, O. Camci, C. Igci, Y.Z. |
| author_facet | Sozucan, Y. Kalender, M.E. Sari, I. Suner, A. Oztuzcu, S. Arman, K. Yumrutas, O. Bozgeyik, I. Cengiz, B. Balakan, O. Camci, C. Igci, Y.Z. |
| citation_txt | TRP genes family expression in colorectal cancer / Y. Sozucan, M.E. Kalender, I. Sari, A. Suner, S. Oztuzcu, K. Arman, O. Yumrutas, I. Bozgeyik, B. Cengiz, Y.Z. Igci, O. Balakan, C. Camci // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 208-212. — Бібліогр.: 31 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract. Different factors are responsible for the development of CRC. Transient Receptor Potential (TRP) which is an important component of calcium channel is associated with several pathological conditions like cancer, neurodegenerative and cardiovascular diseases. Thirty members of the family of TRP ion channel in mammals have been determined till now. The aim of this study is to investigate TRPM, TRPV and TRPC gene expression levels in tumor tissues of CRC patients and to analyze the relationship of expression in tumor tissue of CRC with other known prognostic factors. Material and Methods: In this study, 93 CRC patients were included. The level of TRP gene expression in paraffin blocks of normal and cancerous colorectal tissue samples were studied at the level of mRNA with Real-time PCR. Results: The mRNA expression level of TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 genes in 37 female and 56 male patients diagnosed with CRC was revealed lower in tumor tissue as compared to normal tissue (p < 0.05). No statistically significant differences of mRNA expression levels of other TRP genes were found. Conclusions: TRP gene family like TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 may be thought as potential genes contributing to tumorigenesis as their expression decreases in CRC as compared to normal tissues. Key Words: colorectal cancer, TRP genes family: TRPV3, TRPV4, TRPV5, TRPM4, TRPC6, mRNA expression.
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| first_indexed | 2025-11-25T22:44:27Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145490 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-25T22:44:27Z |
| publishDate | 2015 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Sozucan, Y. Kalender, M.E. Sari, I. Suner, A. Oztuzcu, S. Arman, K. Yumrutas, O. Bozgeyik, I. Cengiz, B. Balakan, O. Camci, C. Igci, Y.Z. 2019-01-22T12:59:50Z 2019-01-22T12:59:50Z 2015 TRP genes family expression in colorectal cancer / Y. Sozucan, M.E. Kalender, I. Sari, A. Suner, S. Oztuzcu, K. Arman, O. Yumrutas, I. Bozgeyik, B. Cengiz, Y.Z. Igci, O. Balakan, C. Camci // Experimental Oncology. — 2015. — Т. 37, № 3. — С. 208-212. — Бібліогр.: 31 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145490 Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract. Different factors are responsible for the development of CRC. Transient Receptor Potential (TRP) which is an important component of calcium channel is associated with several pathological conditions like cancer, neurodegenerative and cardiovascular diseases. Thirty members of the family of TRP ion channel in mammals have been determined till now. The aim of this study is to investigate TRPM, TRPV and TRPC gene expression levels in tumor tissues of CRC patients and to analyze the relationship of expression in tumor tissue of CRC with other known prognostic factors. Material and Methods: In this study, 93 CRC patients were included. The level of TRP gene expression in paraffin blocks of normal and cancerous colorectal tissue samples were studied at the level of mRNA with Real-time PCR. Results: The mRNA expression level of TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 genes in 37 female and 56 male patients diagnosed with CRC was revealed lower in tumor tissue as compared to normal tissue (p < 0.05). No statistically significant differences of mRNA expression levels of other TRP genes were found. Conclusions: TRP gene family like TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 may be thought as potential genes contributing to tumorigenesis as their expression decreases in CRC as compared to normal tissues. Key Words: colorectal cancer, TRP genes family: TRPV3, TRPV4, TRPV5, TRPM4, TRPC6, mRNA expression. Kaifee Arman is a recipient of Graduate Scholarship from TUBITAK under the program 2215 — Graduate Scholarship Programme for International Students. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions TRP genes family expression in colorectal cancer Article published earlier |
| spellingShingle | TRP genes family expression in colorectal cancer Sozucan, Y. Kalender, M.E. Sari, I. Suner, A. Oztuzcu, S. Arman, K. Yumrutas, O. Bozgeyik, I. Cengiz, B. Balakan, O. Camci, C. Igci, Y.Z. Original contributions |
| title | TRP genes family expression in colorectal cancer |
| title_full | TRP genes family expression in colorectal cancer |
| title_fullStr | TRP genes family expression in colorectal cancer |
| title_full_unstemmed | TRP genes family expression in colorectal cancer |
| title_short | TRP genes family expression in colorectal cancer |
| title_sort | trp genes family expression in colorectal cancer |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145490 |
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