Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted...
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| Опубліковано в: : | Experimental Oncology |
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| Дата: | 2015 |
| Автори: | , , , , , , , , , , |
| Формат: | Стаття |
| Мова: | Англійська |
| Опубліковано: |
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Онлайн доступ: | https://nasplib.isofts.kiev.ua/handle/123456789/145543 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Цитувати: | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862740548491673600 |
|---|---|
| author | Sarnatskaya, V.V. Nikolaev, V.G. Yushko, L.A. Paziuk, L.M. Karaman, O.M. Fedosova, N.I. Kolesnik, D.L. Dasyukevich, O.I. Gorbik, G.V. Maslenny, V.N. Solyanik, G.I. |
| author_facet | Sarnatskaya, V.V. Nikolaev, V.G. Yushko, L.A. Paziuk, L.M. Karaman, O.M. Fedosova, N.I. Kolesnik, D.L. Dasyukevich, O.I. Gorbik, G.V. Maslenny, V.N. Solyanik, G.I. |
| citation_txt | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional activity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption.
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| first_indexed | 2025-12-07T20:15:21Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145543 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T20:15:21Z |
| publishDate | 2015 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Sarnatskaya, V.V. Nikolaev, V.G. Yushko, L.A. Paziuk, L.M. Karaman, O.M. Fedosova, N.I. Kolesnik, D.L. Dasyukevich, O.I. Gorbik, G.V. Maslenny, V.N. Solyanik, G.I. 2019-01-22T20:08:59Z 2019-01-22T20:08:59Z 2015 Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145543 Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional activity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption. This study has been supported by fundamental complex program of scientific research of Division of Biochemistry, Physiology and Molecular Biology NAS of Ukraine “Functional genomics and metabolomics in system biology” in the frame of scientific project “Molecular-genentic mechanisms of paraneoplastic syndrome formation associated with tumor angiogenesis, and possible approaches for correction of pathologic alterations”. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma Article published earlier |
| spellingShingle | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma Sarnatskaya, V.V. Nikolaev, V.G. Yushko, L.A. Paziuk, L.M. Karaman, O.M. Fedosova, N.I. Kolesnik, D.L. Dasyukevich, O.I. Gorbik, G.V. Maslenny, V.N. Solyanik, G.I. Original contributions |
| title | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| title_full | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| title_fullStr | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| title_full_unstemmed | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| title_short | Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| title_sort | effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145543 |
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