Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma

Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma

Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted...

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Published in:Experimental Oncology
Date:2015
Main Authors: Sarnatskaya, V.V., Nikolaev, V.G., Yushko, L.A., Paziuk, L.M., Karaman, O.M., Fedosova, N.I., Kolesnik, D.L., Dasyukevich, O.I., Gorbik, G.V., Maslenny, V.N., Solyanik, G.I.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2015
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145543
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145543
record_format dspace
spelling Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
2019-01-22T20:08:59Z
2019-01-22T20:08:59Z
2015
Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145543
Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional acti­vity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption.
This study has been supported by fundamental complex program of scientific research of Division of Biochemistry, Physiology and Molecular Biology NAS of Ukraine “Functional genomics and metabolomics in system bio­logy” in the frame of scientific project “Molecular-genentic mechanisms of paraneoplastic syndrome formation associated with tumor angiogenesis, and possible approaches for correction of pathologic alterations”.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
spellingShingle Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
Original contributions
title_short Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_full Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_fullStr Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_full_unstemmed Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
title_sort effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma
author Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
author_facet Sarnatskaya, V.V.
Nikolaev, V.G.
Yushko, L.A.
Paziuk, L.M.
Karaman, O.M.
Fedosova, N.I.
Kolesnik, D.L.
Dasyukevich, O.I.
Gorbik, G.V.
Maslenny, V.N.
Solyanik, G.I.
topic Original contributions
topic_facet Original contributions
publishDate 2015
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: To study the correcting effects of microgranulated HSGD enterosorbent on hematological, morphological and biochemical indices of paraneoplastic syndrome in mice with highly angiogenic variant of Lewis lung carcinoma LLC/R9. Methods: The study was performed on male С57/ВL6 mice with transplanted LLC/R9. Enterosorbent HSGD was administered daily at a dose of 0.625 g/kg for 2 weeks starting from 7th day after tumor cell transplantation. When enterosorption was completed, an analysis of peripheral blood, biochemical indices and morphological structure of tumor, lung, liver, spleen and thymus was carried out by standard methods. Results: It has been shown that administration of enterosorbent did not affect LLC/R9 growth but resulted in nearly two fold decrease of the volume of lung metastases (p < 0.05). Erythrocyte number and hemoglobin level were higher by 30.0% (p < 0.05) and 23.3% (p < 0.05), respectively, in mice treated with enterosorbents as compared to untreated animals. In addition sorbent treatment completely normalized the thrombocyte index resulting in elevation of platelet number by 54.5% (p < 0.01) up to their level in intact mice. The morphological examination of liver and biochemical analysis of peripheral blood evidenced on significant positive correcting effect of enterosorption on histological structure of this organ and its functional acti­vity. Normalization of total proteins and serum albumin level as well as significant decrease of total lipid concentration by 29% (p < 0.01) in blood of treated mice were observed. Conclusion: Positive influence of microgranulated carbon sorbent on some hematological, morphological and biochemical indices of tumor associated symptoms in LLC/R9-bearing mice denotes that enterosorption-based therapy can be considered as a prospective treatment for correction of some paraneoplastic syndrome signs in cancer patients. Key Words: paraneoplastic syndrome, Lewis lung carcinoma LLC/R9, enterosorption.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145543
citation_txt Effect of enterosorption on paraneoplastic syndrome manifestations in mice with highly angiogenic variant of lewis lung carcinoma / V.V. Sarnatskaya, V.G. Nikolaev, L.A. Yushko, L.M. Paziuk, O.M. Karaman, N.I. Fedosova, D.L. Kolesnik, O.I. Dasyukevich, G.V. Gorbik, V.N. Maslenny, G.I. Solyanik // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 255-261. — Бібліогр.: 19 назв. — англ.
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first_indexed 2025-12-07T20:15:21Z
last_indexed 2025-12-07T20:15:21Z
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