Impact of KRAS variant rs61764370 on breast cancer morbidity
Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3՛ UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determ...
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| Published in: | Experimental Oncology |
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| Date: | 2015 |
| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2015
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145559 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Impact of KRAS variant rs61764370 on breast cancer morbidity / M. Ustinova, Z. Daneberga, D. Berzina, M. Nakazawa-Miklasevica, J. Maksimenko, J. Gardovskis, E. Miklasevics // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 292-294. — Бібліогр.: 7 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862597187591995392 |
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| author | Ustinova, M. Daneberga, Z. Berzina, D. Nakazawa-Miklasevica, M. Maksimenko, J. Gardovskis, J. Miklasevics, E. |
| author_facet | Ustinova, M. Daneberga, Z. Berzina, D. Nakazawa-Miklasevica, M. Maksimenko, J. Gardovskis, J. Miklasevics, E. |
| citation_txt | Impact of KRAS variant rs61764370 on breast cancer morbidity / M. Ustinova, Z. Daneberga, D. Berzina, M. Nakazawa-Miklasevica, J. Maksimenko, J. Gardovskis, E. Miklasevics // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 292-294. — Бібліогр.: 7 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3՛ UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates. Key Words: breast cancer, rs61764370, KRAS variant, predisposing factor.
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| first_indexed | 2025-11-27T17:05:25Z |
| format | Article |
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| id | nasplib_isofts_kiev_ua-123456789-145559 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-27T17:05:25Z |
| publishDate | 2015 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Ustinova, M. Daneberga, Z. Berzina, D. Nakazawa-Miklasevica, M. Maksimenko, J. Gardovskis, J. Miklasevics, E. 2019-01-23T18:26:37Z 2019-01-23T18:26:37Z 2015 Impact of KRAS variant rs61764370 on breast cancer morbidity / M. Ustinova, Z. Daneberga, D. Berzina, M. Nakazawa-Miklasevica, J. Maksimenko, J. Gardovskis, E. Miklasevics // Experimental Oncology. — 2015. — Т. 37, № 4. — С. 292-294. — Бібліогр.: 7 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145559 Low-penetrance gene variants and their combinations are topical study objects in breast cancer pathogenesis. Single nucleotide polymorphism rs61764370, localized in 3՛ UTR of KRAS gene, plays an important role in the development and progression of several cancers. The aim of our study was to determine the KRAS variant impact on breast cancer morbidity. Patients and Methods: 2214 patients diagnosed with breast cancer and 861 healthy controls were screened for KRAS variant by RFLP method. Available clinical data were collected and processed using statistical analysis methods. Results of present study suggest the KRAS variant impact on breast cancer development risk in premenopausal women, but it has no effect on breast cancer prognosis. We did not observe any KRAS variant effect on breast cancer patient 10-year disease-specific survival rates. Key Words: breast cancer, rs61764370, KRAS variant, predisposing factor. This study was funded by European Social Fund grant Nr. 2013/0047/1DP/1.1.1.2.0/13/APIA/VIAA/017. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Short communications Impact of KRAS variant rs61764370 on breast cancer morbidity Article published earlier |
| spellingShingle | Impact of KRAS variant rs61764370 on breast cancer morbidity Ustinova, M. Daneberga, Z. Berzina, D. Nakazawa-Miklasevica, M. Maksimenko, J. Gardovskis, J. Miklasevics, E. Short communications |
| title | Impact of KRAS variant rs61764370 on breast cancer morbidity |
| title_full | Impact of KRAS variant rs61764370 on breast cancer morbidity |
| title_fullStr | Impact of KRAS variant rs61764370 on breast cancer morbidity |
| title_full_unstemmed | Impact of KRAS variant rs61764370 on breast cancer morbidity |
| title_short | Impact of KRAS variant rs61764370 on breast cancer morbidity |
| title_sort | impact of kras variant rs61764370 on breast cancer morbidity |
| topic | Short communications |
| topic_facet | Short communications |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145559 |
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