Increased homocysteine plasma levels in breast cancer patients of a Mexican population

Increased homocysteine plasma levels in breast cancer patients of a Mexican population

Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Mate...

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Published in:Experimental Oncology
Date:2018
Main Authors: Varela Almanza, K.M., Puebla-Pérez, A.M., Delgado-Saucedo, J.I., Rodríguez-Arévalo, F., Zúñiga-González, G.M., Figuera, L.E., Morán-Mendoza, A., Gallegos-Arreola, M.P.
Format: Article
Language:English
Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
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Online Access:https://nasplib.isofts.kiev.ua/handle/123456789/145566
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Journal Title:Digital Library of Periodicals of National Academy of Sciences of Ukraine
Cite this:Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ.

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Digital Library of Periodicals of National Academy of Sciences of Ukraine
id nasplib_isofts_kiev_ua-123456789-145566
record_format dspace
spelling Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
2019-01-24T08:06:08Z
2019-01-24T08:06:08Z
2018
Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ.
1812-9269
https://nasplib.isofts.kiev.ua/handle/123456789/145566
Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population.
The authors would like to thank the nurses for their assistance with extracting the blood samples. This research was financially supported in part through FIS/IMSS/PROT/G15/1463 grants.
en
Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
Experimental Oncology
Original contributions
Increased homocysteine plasma levels in breast cancer patients of a Mexican population
Article
published earlier
institution Digital Library of Periodicals of National Academy of Sciences of Ukraine
collection DSpace DC
title Increased homocysteine plasma levels in breast cancer patients of a Mexican population
spellingShingle Increased homocysteine plasma levels in breast cancer patients of a Mexican population
Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
Original contributions
title_short Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_full Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_fullStr Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_full_unstemmed Increased homocysteine plasma levels in breast cancer patients of a Mexican population
title_sort increased homocysteine plasma levels in breast cancer patients of a mexican population
author Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
author_facet Varela Almanza, K.M.
Puebla-Pérez, A.M.
Delgado-Saucedo, J.I.
Rodríguez-Arévalo, F.
Zúñiga-González, G.M.
Figuera, L.E.
Morán-Mendoza, A.
Gallegos-Arreola, M.P.
topic Original contributions
topic_facet Original contributions
publishDate 2018
language English
container_title Experimental Oncology
publisher Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
format Article
description Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population.
issn 1812-9269
url https://nasplib.isofts.kiev.ua/handle/123456789/145566
citation_txt Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ.
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first_indexed 2025-12-07T21:08:31Z
last_indexed 2025-12-07T21:08:31Z
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