Increased homocysteine plasma levels in breast cancer patients of a Mexican population
Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Mate...
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| Published in: | Experimental Oncology |
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| Date: | 2018 |
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
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| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/145566 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862750898427527168 |
|---|---|
| author | Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. |
| author_facet | Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. |
| citation_txt | Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population.
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| first_indexed | 2025-12-07T21:08:31Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145566 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-12-07T21:08:31Z |
| publishDate | 2018 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
| record_format | dspace |
| spelling | Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. 2019-01-24T08:06:08Z 2019-01-24T08:06:08Z 2018 Increased homocysteine plasma levels in breast cancer patients of a Mexican population / K.M. Varela Almanza, A.M. Puebla-Pérez, J.I. Delgado-Saucedo, F. Rodríguez-Arévalo, G.M. Zúñiga-González, L.E. Figuera, A. Morán-Mendoza, M.P. Gallegos-Arreola // Experimental Oncology. — 2018 — Т. 40, № 2. — С. 114–118. — Бібліогр.: 35 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145566 Aim: Hyperhomocysteinemia has been associated with different pathologies, including cardiovascular diseases, hypertension, diabetes, and breast cancer (BC). To examine the differences in total homocysteine (tHcy) plasma levels, we compared healthy women to BC patients from a Mexican population. Materials and Methods: The tHcy plasma levels were measured using high-performance liquid chromatography with a fluorescence detector in 89 female controls and 261 BC patients. Results: The observed plasma tHcy levels were significantly higher among the BC patients (11.1019 ± 5.9161 µmol/l) compared to the controls (9.1046 ± 1.3213 µmol/l) (p = 0.002), and these differences were evident when stratified by age (≥ 50 years old), menopause status, overweight and obesity, miscarriages, node metastases, progression, subtype classification (luminal, Her2 and triple negative) and nonresponse to chemotherapy. Conclusions: The tHcy plasma levels could be a good marker for the progression and chemosensitivity of BC in the analyzed sample from a Mexican population. Key Words: plasma levels, homocysteine, HPLC, breast cancer, Mexican population. The authors would like to thank the nurses for their assistance with extracting the blood samples. This research was financially supported in part through FIS/IMSS/PROT/G15/1463 grants. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Increased homocysteine plasma levels in breast cancer patients of a Mexican population Article published earlier |
| spellingShingle | Increased homocysteine plasma levels in breast cancer patients of a Mexican population Varela Almanza, K.M. Puebla-Pérez, A.M. Delgado-Saucedo, J.I. Rodríguez-Arévalo, F. Zúñiga-González, G.M. Figuera, L.E. Morán-Mendoza, A. Gallegos-Arreola, M.P. Original contributions |
| title | Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_full | Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_fullStr | Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_full_unstemmed | Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_short | Increased homocysteine plasma levels in breast cancer patients of a Mexican population |
| title_sort | increased homocysteine plasma levels in breast cancer patients of a mexican population |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145566 |
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