Role of dendrimers in advanced drug delivery and biomedical applications: a review

• Published in: Experimental Oncology
• Date: 2018
• Main Authors: Akbarzadeh, A., Khalilov, R., Mostafavi, E., Annabi, N., Abasi, E., Kafshdooz, T., Herizchi, R., Kavetskyy, T., Saghf, S., Nasibova, A., Davaran, S.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
• Subjects: Reviews
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145596
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh, R. Khalilov, E. Mostafavi, N. Annabi, E. Abasi, T. Kafshdooz, R. Herizchi, T. Kavetskyy, S. Saghfi, A. Nasibova, S. Davaran // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 178–183. — Бібліогр.: 91 назв. — англ.

Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration. This article reviews role of dendrimers in advanced drug delivery and biomedical applications. Key Words: dendrimers, drug delivery vehicle, lipid bilayer interactions, dendritic architecture.