Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6

• Published in: Experimental Oncology
• Date: 2018
• Main Authors: Prokhorova, I.V., Pyaskovskaya, O.N., Kolesnik, D.L., Solyanik, G.I.
• Format: Article
• Language: English
• Published: Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України 2018
• Subjects: Original contributions
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/145635
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I.V. Prokhorova, O.N. Pyaskovskaya, D.L. Kolesnik, G.I. Solyanik // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 205-210. — Бібліогр.: 30 назв. — англ.

Background: The efficacy of antimetabolic therapy of malignant neoplasms could not be explained solely by the direct mechanisms of action of such energy metabolism inhibitors as sodium dichloroacetate (DCA) and metformin (MTF). The indirect effects of DCA and MTF on the organs and tissues, which cou...