Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma
Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistoch...
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| Veröffentlicht in: | Experimental Oncology |
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| Datum: | 2018 |
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| Format: | Artikel |
| Sprache: | Englisch |
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Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України
2018
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| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/145637 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| _version_ | 1862637293535232000 |
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| author | Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. |
| author_facet | Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. |
| citation_txt | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. |
| collection | DSpace DC |
| container_title | Experimental Oncology |
| description | Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p < 0.001 and 54.5 ± 2.6%, respectively, p < 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin.
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| first_indexed | 2025-11-30T22:43:57Z |
| format | Article |
| fulltext | |
| id | nasplib_isofts_kiev_ua-123456789-145637 |
| institution | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| issn | 1812-9269 |
| language | English |
| last_indexed | 2025-11-30T22:43:57Z |
| publishDate | 2018 |
| publisher | Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України |
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| spelling | Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. 2019-01-25T16:00:10Z 2019-01-25T16:00:10Z 2018 Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I.P. Nesina, N.P. Iurchenko, L.G. Buchynska // Experimental Oncology. — 2018 — Т. 40, № 3. — С. 218–222. — Бібліогр.: 33 назв. — англ. 1812-9269 https://nasplib.isofts.kiev.ua/handle/123456789/145637 Aim: To study the expression of adhesion markers (E-cadherin, β-catenin and vimentin) associated with epithelial-mesenchymal transition (EMT) and their role in progression of endometrial carcinoma (EC). Materials and Methods: Expression of E-cadherin, β-catenin and vimentin was studied immunohistochemically in the samples of surgical material of 55 EC patients stage I–III. The proliferation index was determined by flow cytometry. Results: In the group of vimentin-negative EC, tumors of low differentiation grade and deep invasion in myometrium as well as high expression of E-cadherin and β-catenin prevailed compared with the cases with high expression of vimentin. In addition, in EC with high expression of vimentin, an increase in the number of cells with expression of E-cadherin in the cytoplasm (78.9 ± 3.6%) and β-catenin with cytoplasmic-nuclear localization (73.7 ± 3.2%) was observed compared with these indices in vimentin-negative tumors (45.4 ± 4.2%, p < 0.001 and 54.5 ± 2.6%, respectively, p < 0.005), which may indicate EMT-associated changes in EC with high expression of vimentin. Conclusions: The progression of the endometrioid carcinoma may occur in the setting of various molecular changes, in particular, with decreased expression of E-cadherin and β-catenin and high expression of vimentin, or in the absence of vimentin, utilizing other mechanisms of regulation of proliferative and metastatic potential. Key Words: endometrial cancer, proliferation index, E-cadherin, β-catenin, vimentin. Authors are grateful to S.V. Nespryadko, MD (National Cancer Institute of MH of Ukraine) for providing tissue samples of EC. en Інститут експериментальної патології, онкології і радіобіології ім. Р.Є. Кавецького НАН України Experimental Oncology Original contributions Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma Article published earlier |
| spellingShingle | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma Nesina, I.P. Iurchenko, N.P. Buchynska, L.G. Original contributions |
| title | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_full | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_fullStr | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_full_unstemmed | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_short | Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| title_sort | markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma |
| topic | Original contributions |
| topic_facet | Original contributions |
| url | https://nasplib.isofts.kiev.ua/handle/123456789/145637 |
| work_keys_str_mv | AT nesinaip markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma AT iurchenkonp markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma AT buchynskalg markersoftheepithelialmesenchymaltransitionincellsofendometrialcarcinoma |