Effects of Scorpion Venom Heat-Resistant Protein on Seizure Behavior and Expression of Proenkephalin in Rats with Kainate-Induced Epilepsy
Scorpion venom is a traditional antiepileptic medicine in Asia. We examined the effects of scorpion venom heat-resistant protein (SVHRP) on seizure behavior of rats with kainate-induced epilepsy and expression of proenkephalin (pENK) in their hippocampus. Subcutaneous injections of convulsive dos...
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| Datum: | 2013 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | English |
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Інститут фізіології ім. О.О. Богомольця НАН України
2013
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| Schriftenreihe: | Нейрофизиология |
| Online Zugang: | https://nasplib.isofts.kiev.ua/handle/123456789/148124 |
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| Назва журналу: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Zitieren: | Effects of Scorpion Venom Heat-Resistant Protein on Seizure Behavior and Expression of Proenkephalin in Rats with Kainate-Induced Epilepsy / Y. Sun, X. Cui, Sh. Yin, D. Yu, Sh. Li, W. Zhang, J. Zhao // Нейрофизиология. — 2013. — Т. 45, № 4. — С. 358-361. — Бібліогр.: 11 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Zusammenfassung: | Scorpion venom is a traditional antiepileptic medicine in Asia. We examined the effects
of scorpion venom heat-resistant protein (SVHRP) on seizure behavior of rats with
kainate-induced epilepsy and expression of proenkephalin (pENK) in their hippocampus.
Subcutaneous injections of convulsive doses of kainic acid (KA, 10 mg/kg) evoked acute
epileptic seizures; the intensity of such seizures was measured after subsequent injections
of lower (subthreshold in the norm) doses of KA (5 mg/kg). Scorpion venom heat-resistant
protein in a dose of 125 mg/kg was given in a part of the animals through i.p. injections
daily during 10 days; rats of the control groups were injected with normal saline. Behavioral
indices were measured, and the hippocampus was taken for pENK mRNA estimation by RTPCR analysis. The mean behavioral score of seizure sensitivity in the SVHRP-treated group
was smaller significantly (P < 0.05) compared to that in the control group (1.19 vs 2.93).
The pENK mRNA level was dramatically greater in hippocampal neurons of KA-treated rats
with a high seizure sensitivity, while in the SVHRP-treated group the respective index was
significantly lower. Thus, SVHRP inhibits behavior seizures in epilepsy and reverses the
abnormally increased pENK mRNA in hippocampal neurons of such animals |
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