Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients
The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity, anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The cross-secti...
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Інститут фізіології ім. О.О. Богомольця НАН України
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| Цитувати: | Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients / S. Tomasevic-Todorovic, K. Boskovic, D. Filipovic, B. Milekic, M. Grajic, F. Hanna // Нейрофизиология. — 2015. — Т. 47, № 2. — С. 163-168. — Бібліогр.: 32 назв. — англ. |
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Tomasevic-Todorovic, S. Boskovic, K. Filipovic, D. Milekic, B. Grajic, M. Hanna, F. 2019-02-17T16:30:02Z 2019-02-17T16:30:02Z 2015 Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients / S. Tomasevic-Todorovic, K. Boskovic, D. Filipovic, B. Milekic, M. Grajic, F. Hanna // Нейрофизиология. — 2015. — Т. 47, № 2. — С. 163-168. — Бібліогр.: 32 назв. — англ. 0028-2561 https://nasplib.isofts.kiev.ua/handle/123456789/148180 616.72 – 002.77:612.014 The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity, anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The cross-sectional study included 53 women with RA (RA group; mean age 50.58 ± 0.93 years) and 27 healthy women (control group, C; 49.41 ± 1.08 years). The intensity and unpleasantness of pain were determined using a visual analog scale (VAS); the functional status was assessed using HAQ (Health Assessment Questionnaire), and the disease activity was estimated using the disease activity scale (DAS28). The P300 waves initiated by auditory stimulations according to the oddball paradigm were recorded from leads Fz and Cz. There were no significant differences between the P300 latencies in both leads. At the same time, the average P300 amplitudes in both leads were found to be considerably lower (P < 0.05) in the RA group compared to the C group. Thus, there is a statistically significant amplitude difference between the P300 cognitive ERPs in RA patients and control subjects. Були досліджені параметри пов’язаних із подією потенціалів (ППП) P300 у пацієнтів, що страждають на ревматоїдний артрит (РА), та зв’язок цих параметрів із тривалістю та інтенсивністю захворювання, анатомічною та функціональною стадіями останнього, інтенсивністю та неприємністю відчуттів болю. У порівняльне дослідження були залучені 53 жінки з РА (група RA, середній вік 50.58 ± ± 0.94 року) та 27 здорових жінок (контрольна група C, 49.41 ± 1.08 року). Інтенсивність та рівень неприємності болю визначали за допомогою візуальної аналогової шкали (VAS), функціональний статус – згідно з опитувальником HAQ, а інтенсивність хвороби – за шкалою DAS28. Потенціали P300 ініціювали акустичною стимуляцією відповідно до oddball-парадигми та відводили від точок Fz та Cz. Усереднені значення латентних періодів хвилі P300 в групах RA та C не демонстрували якихось істотних відмінностей. У той же час усереднені амплітуди P300 в обох кортикальних зонах у групі RA були вірогідно нижчими (P < 0.05), ніж відповідні величини в групі C. Таким чином, існує статистично значуща різниця між характеристиками когнітивного ППП P300 у пацієнтів із ревматоїдним артритом та здорових суб’єктів, що вказує на негативні зміни сенсорного процесінга та уваги, а також когнітивні дисфункції, виниклі під впливом хронічного болю. en Інститут фізіології ім. О.О. Богомольця НАН України Нейрофизиология Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients Слухові пов’язані з подією потенціали P300 у пацієнтів із ревматоїдним артритом Article published earlier |
| institution |
Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| collection |
DSpace DC |
| title |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients |
| spellingShingle |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients Tomasevic-Todorovic, S. Boskovic, K. Filipovic, D. Milekic, B. Grajic, M. Hanna, F. |
| title_short |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients |
| title_full |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients |
| title_fullStr |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients |
| title_full_unstemmed |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients |
| title_sort |
auditory event-related p300 potentials in rheumatoid arthritis patients |
| author |
Tomasevic-Todorovic, S. Boskovic, K. Filipovic, D. Milekic, B. Grajic, M. Hanna, F. |
| author_facet |
Tomasevic-Todorovic, S. Boskovic, K. Filipovic, D. Milekic, B. Grajic, M. Hanna, F. |
| publishDate |
2015 |
| language |
English |
| container_title |
Нейрофизиология |
| publisher |
Інститут фізіології ім. О.О. Богомольця НАН України |
| format |
Article |
| title_alt |
Слухові пов’язані з подією потенціали P300 у пацієнтів із ревматоїдним артритом |
| description |
The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering
from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity,
anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The
cross-sectional study included 53 women with RA (RA group; mean age 50.58 ± 0.93 years)
and 27 healthy women (control group, C; 49.41 ± 1.08 years). The intensity and unpleasantness of pain were determined using a visual analog scale (VAS); the functional status was assessed using HAQ (Health Assessment Questionnaire), and the disease activity was estimated
using the disease activity scale (DAS28). The P300 waves initiated by auditory stimulations
according to the oddball paradigm were recorded from leads Fz and Cz. There were no significant differences between the P300 latencies in both leads. At the same time, the average
P300 amplitudes in both leads were found to be considerably lower (P < 0.05) in the RA
group compared to the C group. Thus, there is a statistically significant amplitude difference
between the P300 cognitive ERPs in RA patients and control subjects.
Були досліджені параметри пов’язаних із подією
потенціалів (ППП) P300 у пацієнтів, що страждають на
ревматоїдний артрит (РА), та зв’язок цих параметрів із
тривалістю та інтенсивністю захворювання, анатомічною
та функціональною стадіями останнього, інтенсивністю та
неприємністю відчуттів болю. У порівняльне дослідження
були залучені 53 жінки з РА (група RA, середній вік 50.58 ±
± 0.94 року) та 27 здорових жінок (контрольна група C,
49.41 ± 1.08 року). Інтенсивність та рівень неприємності
болю визначали за допомогою візуальної аналогової шкали (VAS), функціональний статус – згідно з опитувальником HAQ, а інтенсивність хвороби – за шкалою DAS28.
Потенціали P300 ініціювали акустичною стимуляцією
відповідно до oddball-парадигми та відводили від точок
Fz та Cz. Усереднені значення латентних періодів хвилі
P300 в групах RA та C не демонстрували якихось істотних
відмінностей. У той же час усереднені амплітуди P300 в
обох кортикальних зонах у групі RA були вірогідно нижчими (P < 0.05), ніж відповідні величини в групі C. Таким чином, існує статистично значуща різниця між характеристиками когнітивного ППП P300 у пацієнтів із ревматоїдним
артритом та здорових суб’єктів, що вказує на негативні
зміни сенсорного процесінга та уваги, а також когнітивні
дисфункції, виниклі під впливом хронічного болю.
|
| issn |
0028-2561 |
| url |
https://nasplib.isofts.kiev.ua/handle/123456789/148180 |
| citation_txt |
Auditory Event-Related P300 Potentials in Rheumatoid Arthritis Patients / S. Tomasevic-Todorovic, K. Boskovic, D. Filipovic, B. Milekic, M. Grajic, F. Hanna // Нейрофизиология. — 2015. — Т. 47, № 2. — С. 163-168. — Бібліогр.: 32 назв. — англ. |
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NEUROPHYSIOLOGY / НЕЙРОФИЗИОЛОГИЯ.—2015.—T. 47, № 2 163
UDC 616.72 – 002.77:612.014
S. TOMASEVIC-TODOROVIC,1 K. BOSKOVIC,1 D. FILIPOVIC,1 B. MILEKIC,1, M. GRAJIC,2 and F. HANNA3
AUDITORY EVENT-RELATED P300 POTENTIALS IN RHEUMATOID ARTHRITIS
PATIENTS
Received December 4, 2013
The aim of the study was to assess P300 event-related potentials (ERPs) in patients suffering
from rheumatoid arthritis (RA) in relation to the duration of illness, degree of disease activity,
anatomical and functional stage of the disease, pain intensity, and pain unpleasantness. The
cross-sectional study included 53 women with RA (RA group; mean age 50.58 ± 0.93 years)
and 27 healthy women (control group, C; 49.41 ± 1.08 years). The intensity and unpleasant-
ness of pain were determined using a visual analog scale (VAS); the functional status was as-
sessed using HAQ (Health Assessment Questionnaire), and the disease activity was estimated
using the disease activity scale (DAS28). The P300 waves initiated by auditory stimulations
according to the oddball paradigm were recorded from leads Fz and Cz. There were no sig-
nificant differences between the P300 latencies in both leads. At the same time, the average
P300 amplitudes in both leads were found to be considerably lower (P < 0.05) in the RA
group compared to the C group. Thus, there is a statistically significant amplitude difference
between the P300 cognitive ERPs in RA patients and control subjects.
Keywords: P300 event-related potentials (ERPs), rheumatoid arthritis, pain intensity,
pain unpleasantness, visual analog scale (VAS).
1 Faculty of Medicine, University of Novi Sad, Clinical Center of Vojvodina,
Clinic for Medical Rehabilitation, Novi Sad, Serbia.
2 Faculty of Medicine, University of Belgrade, Clinic for Physical and
Rehabilitation Medicine, Clinical Center of Serbia, Belgrade, Serbia.
3 School of Rural Health, Monash University, Melbourne, Australia.
Correspondence should be addressed to S. Tomasevic-Todorovic
(e-mail: drtomasevic@gmail.com).
INTRODUCTION
Rheumatoid arthritis (RA) is a chronic painful
condition causing progressive irreversible damage
to the articular and periarticular structures, their
deformation and functional impairment, cognitive and
emotional difficulties, and significant reduction of the
quality of life [1]. Cognitive complaints, impairment
of attention, memory (especially short-term) loss, loss
of spatial orientation and concentration, visuospatial
alterations, and disorders of motor planning and
mental flexibility are frequently observed in patients
with RA [2-5]. Data obtained from simple and
complex psychometric measurements in patients
suffering from RA are indicative of the impact of
pain on cognitive functioning and demonstrate the
necessity for developing new therapeutic strategies
[6-8]. Application of modern methods of functional
diagnostics demonstrated association of chronic pain
with changes in the brain structures and functions in
patients with RA [9, 10]. Literature data also suggest
complex interaction of sensory processing, attention,
and cognition with chronic painful conditions; further
research on the mechanisms of pain perception and
cognitive dysfunctions related to the mentioned
pathology is needed [5, 11].
Studies on cognitive P300 potentials during of the
last 20 years were rather intense and clearly indicated
the importance of application in these phenomena in
clinical studies. Cognitive event-related potentials
(ERPs) are defined as small-amplitude phasic EEG
potentials related to some cognitive events; such
potentials represent a sensitive indicator of the state of
higher cortical functions [12]. These potentials include
a series of negative and positive waves with a wide
distribution on the scalp; the respective components
are marked N1, P1, N2, P2, and P3 (P300) waves. The
P300 wave is an ERP usually registered within the so-
called oddball experimental paradigm. It is a positive
wave whose peak latency in a healthy population
varies between 300 and 500 msec after stimulation; a
maximum amplitude of this potential is observed over
the central and parietal regions of the cerebral cortex.
NEUROPHYSIOLOGY / НЕЙРОФИЗИОЛОГИЯ.—2015.—T. 47, № 2164
S. TOMASEVIC-TODOROVIC,1 K. BOSKOVIC,1 D. FILIPOVIC et al.
It is believed that the P300 wave is a neuroelectrical
indicator of CNS activity related to processing of new
information and guidance of attention to updating the
memory performance [13, 14].
The P300 wave is a manifestation of the CNS in-
volvement in the processing of new information when
attention is engaged in refreshing memory. It is an en-
dogenous response to a task that is not a certain direct
answer to that of the target stimulus [15]. The ampli-
tude of this potential is associated with the scope of at-
tention focusing on a task and with the refreshing rate
of the contents of working memory. Variations in the
amplitude of P300 reflect the level and quality of han-
dling incoming information. The P300 latency is a mea-
sure of the relative duration of the evaluation process,
i.e., a parameter that represents the neurophysiologi-
cal correlate with the rate of the cognitive processes
[15]. Components of P300 ERPs are susceptible to the
effects of many factors (nature of the stimuli and a va-
riety of biological determinants), but this does not di-
minish the significance and clinical application of these
potentials [14, 16, 17]. The P300 ERPs were tested
many times in a number of clinical conditions [18].
The aim of our study was to examine the parameters
of auditory P300 potentials in RA patients in relation
to the duration of illness, degree of disease activity,
anatomical and functional stage of the disease, and in-
tensity and unpleasantness of pain.
METHODS
The study involved 80 subjects who were familiar
with the preliminary examination. The RA group
included 53 women (mean age 50.58 ± 0.93 years)
who fulfilled the criteria for the diagnosis of RA based
on the American Rheumatology Association (ARA,
1987) statements. The C (control) group consisted of
27 healthy women (age 49.41 ± 1.08 years) and was
used to define the norms of neuropsychological and
neurophysiological parameters taken into account in
the tests. Each participant was provided with detailed
information on how to prepare for the test and the type
of applied tests and tasks.
The exclusion criteria included hearing impairment,
dementia, neurological and psychiatric diseases,
head trauma, use of psychoactive substances and/or
antidepressants three weeks before the survey, and
surgery a month before the survey.
In the RA group, the following parameters were
collected: number of painful and swollen joints,
intensity of pain in the joints of patients evaluated by
a visual analog scale (VAS) of 0-100 mm, degree of
discomfort according to the VAS of 0-100 mm, speed
sedimentation rate, a disease activity index, anatomical
stage, and functional class of patients.
Auditory P300 ERPs. Registration of auditory
P300 ERPs was performed using a Medtronic set. Two
AgCl electrodes (impendance below 5 kΩ) were fixed
in the Fz and Cz positions according to the standard
10-20 international system. The reference electrode
was composed of two linked contacts on the mastoids,
and the grounding electrode was on the subject’s
forearm. We used the oddball paradigm with two tones,
“standard” of 90 dB and 1 kHz and “unexpected” of
90 dB and 2 kHz, presented binaurally with randomized
irregular intervals through special headsets. Subjects
were instructed to ignore the standard tones and to
react as quickly as possible to the unexpected tone by
counting and pressing a lever set held in the dominant
hand. Two hundred sixty trials with the relationship
between the standard and unexpected tones of 80 vs.
20% were recorded.
Processing of ERP waves included individual visual
identification of the highest positive wave within a
220-450 msec window for each lead and measurements
of the amplitude and latency of P300 potentials.
Statistical Analysis. Parametric (Student’s t-test)
and nonparametric (Mann–Whitney test and χ2 test)
tests were used to compare the distributions related
to two groups. To compare three or more groups of
respondents, the analysis of variance (ANOVA)
and Kruskal–Wallis test were used. Correlation of
continuous variables was examined by calculation of
the Pearson correlation coefficients.
The software package STATISTICA 8.0 licensed
from the University of Novi Sad was used.
RESULTS
The RA and C groups did not differ significantly
from each other in relation to age, education level, or
marital status (P > 0.1 in all cases).
The results of tests of functional ability of the
patients (RA group) using the Health Assessment
Questionnaire (HAQ) showed the average value of
0.92 ± 0.67, and the average disease activity (DAS28)
was 4.99 ± 0.85 (Table 1). Thirty one (58.49%) patients
had moderately active disease, while 22 (41.51%) had
highly active disease.
A rather high average value of the pain intensity
NEUROPHYSIOLOGY / НЕЙРОФИЗИОЛОГИЯ.—2015.—T. 47, № 2 165
AUDITORY EVENT-RELATED P300 POTENTIALS IN RHEUMATOID ARTHRITIS PATIENTS
according to the VAS scale (56.51 mm) and the
average pain unpleasantness of 58.11 mm were found
(Table 1). Twenty eight (52.83%) RA patients had a
pain intensity on the VAS scale greater than 50 mm,
and 31 subjects (58.5%) manifested a strong degree of
pain unpleasantness (VAS ˃ 50 mm) (Table 2).
Auditory P300 ERPs. The mean latencies of the
P300 wave in leads Fz and Cz were 332.53 ± 21.63
and 331.38 ± 23.69 msec in the C group, while the
respective values in the RA group were 334.74 ± 36.54
and 339.07 ± 36.02 msec. There were no significant
intergroup differences between the P300 latencies
recorded from both Fz and Cz (P > 0.1 in both cases).
The mean amplitudes of the examined ERP in leads Fz
and Cz were 10.84 ± 8.01 and 9.12 ± 6.72 µV in the
C group vs. 6.09 ± 4.56 and 5.41 ± 3.27 µV in the RA
group, respectively. Thus, the amplitudes of auditory
P300 potentials recorded within the oldball paradigm
were significantly smaller in patients suffering from
RA, as compared with the analogous values in healthy
subjects.
Estimation of the correlation coefficients for
the parameters of P300 potentials with the indices
of disease activity showed statistically significant
inverse correlations of the P300 latency in leads Fz
and Cz with the functional class and intensity of
T a b l e 1. Values of the Estimates of Disease Activity in the RA Group
Т а б л и ц я 1. Значення оцінок активності хвороби у пацієнтів із ревматоїдним артритом
Indices of disease activity M ± s.d.
Disease duration, years 9.83 ± 7.74
Anatomical stage 2.00 ± 0.64
Functional class 2.06 ± 0,61
Disease acitivity (DAS28) 4.99 ± 0.85
HAQ 0.92 ± 0.67
Intensity of pain, VAS, mm 56.51 ± 21.92
Unpleasantness of pain, VAS, mm 58.11 ± 23.57
Footnotes: means ± s.d. are shown, DAS28 is the disease activity score 28, HAQ is the Health Assessment Questionnaire, and VAS in the
visual analog scale
T a b l e 2. Intensity and Unpleasantness of Pain in the RA Group Estimated by VAS
Т а б л и ц я 2. Інтенсивність та неприємність болю, оцінювані згідно з VAS
VAS, mm
Intensity of pain Unpleasantness of pain
n % n %
< 25 5 9.43 7 13.21
25 to 50 20 37.74 15 28.30
51 to 75 18 33.96 14 26.42
> 75 10 18.87 17 32.08
Total 53 100 53 100
T a b l e 3. Correlation of the P300 ERP Parameters with Indices of Disease Activity in the RA Group
Т а б л и ц я 3. Кореляції параметрів хвилі P300 з індексами активності хвороби у пацієнтів із ревматоїдним артритом
Indices of disease activity
P values for the P300
amplitude in Fz latency in Fz amplitude in Cz latency in Cz
Duration of illness –0.17 –0.01 –0.15 –0.03
Anatomical stage –0.05 –0.22 –0.15 –0.21
Functional class –0.12 –0.32 –0.12 –0.30
DAS28 –0.12 –0.12 0.01 –0.15
HAQ –0.18 –0.10 –0.06 –0.09
Intensity of pain –0.21 –0.38 –0.23 –0.40
Unpleasantness of pain –0.22 –0.20 –0.16 –0.20
Footnote: P values greater than 0.3 are shown in bold.
NEUROPHYSIOLOGY / НЕЙРОФИЗИОЛОГИЯ.—2015.—T. 47, № 2166
S. TOMASEVIC-TODOROVIC,1 K. BOSKOVIC,1 D. FILIPOVIC et al.
pain by the VAS (P < 0.05; Table 3). In the group of
RA patients, there was weak correlation of the P300
latency in the above leads with unpleasantness of pain
(P = 0.065) and some trend toward correlation with
the anatomical stage of RA (P < 0.1; Table 3). In this
table, the coefficients of correlation between the P300
amplitudes in Fz and Cz and indices of disease activity
are also shown.
DISCUSSION
Complex cognitive functions are particularly
vulnerable with respect to the impact of various factors,
and their dysfunction and recovery can be monitored
by applying the method of ERP recording. Auditory
P300 ERPs are often applied for the assessment
of cognitive functions; they have sufficiently high
amplitudes and long enough latency. These potentials
can be registered under relatively simple experimental
conditions and are reliable and reproducible [17]. The
P300 latency is an indicator of the potential rate of
stimulus classification, while the amplitude reflects
brain activity associated with the task. It is believed
that comparatively longer latencies of the P300 wave
show that the stimulus evaluation time is prolonged,
while lower amplitudes are related to the reduced
capacity of attention that is characteristic of the
painful condition [18, 19].
Yoldas and al. [20] compared the cognitive function
in 11 patients with chronic pain and in healthy subjects
and found significantly lower P300 amplitudes, but not
longer latencies, compared to those in healthy subjects.
These authors showed that there is a correlation
between the amplitude of P300 potentials and pain
intensity (myalgic total score).
Comparable results were obtained by Alagonlu et
al. [22], who believed that a decline in the amplitude
of the P300 potential is indicative of a noticeable
cognitive dysfunction in subjects with chronic pain.
Results of the analysis of the effects of pain on
the P300 ERP components are contradictory to some
extent. In some studies, pain-related differences in
the P300 latency were not detected [21-23], while
Alagonlu et al. [20] found an increase in the latency
in patients suffering from chronic pain (fibromyalgia
syndrome), compared to that in healthy subjects. We
found neither a significant increment nor a noticeable
trend toward such a change in the average P300
latency in RA patients. At the same time, there was
a clear statistically significant difference between the
amplitudes of P300 waves in Fz and Cz sites in the RA
and C groups; the respective values in the RA group
were noticeably smaller than those in healthy subjects
(Fig. 1). This is consistent with the findings of other
authors [13, 17, 22, 23].
The obtained results of the measurement of
characteristics of P300 ERPs in patients with RA
should be interpreted considering a number of
negative impacts on the cognitive functions under
condition of this pathology. The action of these
factors can be partly corrected by kinesiotherapy
(improved cerebral circulation, increased “arousal,”
more effective consumption of oxygen, changes in the
concentration of endorphins). A wide range of research
on the relationship between psychological distress-
depression/chronic pain and cognitive abilities in
patients with RA did not give clear information in this
respect [24-28]. Application of functional magnetic
resonance imaging showed that the association of pain
with fear and anxiety activates various brain structures,
leading to the development of cognitive dysfunction
[29-31]. The most intense correlation between pain
and ERP P300 characteristics are manifested when
recording of the latter is related to easy cognitive tasks
[32].
Examination of the correlation between parameters
of the P300 potentials and indices of disease activity
C RA
5
6
7
8
9
10
11
12
13
14
C RA
4
5
6
7
8
9
10
11
12
F i g. 1. Average amplitudes (µV) of the P300
wave in leads Fz (A) and Cz (B) in the control
(C) and rheumatoid arthritis (RA) groups.
Середні амплітуди потенціалів P300 у
відведеннях Fz (A) та Cz (B) у групах
контролю (C) та пацієнтів із ревматоїдним
артритом (RA).
AµV
µV
B
NEUROPHYSIOLOGY / НЕЙРОФИЗИОЛОГИЯ.—2015.—T. 47, № 2 167
AUDITORY EVENT-RELATED P300 POTENTIALS IN RHEUMATOID ARTHRITIS PATIENTS
in the RA group allowed us to find a statistically
significant inverse correlation between the P300
latencies with the intensity of pain by VAS (P < 0.05)
and functional class (P < 0.05), which is consistent
with results of the studies conducted in patients with
various chronic pain conditions [22].
In the group of RA patients, we also found a
negative weak correlation between the latencies of
P300 potentials and pain unpleasantness estimated
according to VAS (P < 0.1).
The studies carried out have not provided researchers
with clear answers on how the cognitive mechanisms
are impaired under chronic pain conditions. Therefore,
further research on predictive factors with respect to
cognitive dysfunction is necessary, and analysis of
ERP characteristics in the respective groups may be
valuable.
All testing procedures were in accordance with the
ethical standards of the responsible Committees on human
experimentation (institutional and national) and with the
Helsinki Declaration of 1975, as revised in 2000. Written
informed consent was obtained from all persons included in
the study.
The authors of this study, S. Tomasevic-Todorovic, K.
Boskovic, D. Filipovic, B. Milekic, M. Grajic, and F. Hanna,
confirm that the research and publication of the results were not
associated with any conflicts regarding commercial or financial
relations, relations with organizations and/or individuals who
may have been related to the study, and interrelations between
co-authors of the article.
С. Томашевич-Тодорович1, К. Боскович1, Д. Філіпович1,
М. Граджич2, Ф. Ханна3
СЛУХОВІ ПОВ’ЯЗАНІ З ПОДІЄЮ ПОТЕНЦІАЛИ P300 У
ПАЦІЄНТІВ ІЗ РЕВМАТОЇДНИМ АРТРИТОМ
1 Університет у м. Нові Сад, Клінічний центр Воєводини,
Клініка медичної реабілітації, Нові Сад (Сербія).
2 Белградський університет, Клініка фізичної та
реабілітаційної медицини, Клінічний центр Сербії, Бел-
град (Сербія).
3 Коледж охорони здоров’я неміського населення при
Університеті ім. Монаша, Мельбурн (Австралія).
Р е з ю м е
Були досліджені параметри пов’язаних із подією
потенціалів (ППП) P300 у пацієнтів, що страждають на
ревматоїдний артрит (РА), та зв’язок цих параметрів із
тривалістю та інтенсивністю захворювання, анатомічною
та функціональною стадіями останнього, інтенсивністю та
неприємністю відчуттів болю. У порівняльне дослідження
були залучені 53 жінки з РА (група RA, середній вік 50.58 ±
± 0.94 року) та 27 здорових жінок (контрольна група C,
49.41 ± 1.08 року). Інтенсивність та рівень неприємності
болю визначали за допомогою візуальної аналогової шка-
ли (VAS), функціональний статус – згідно з опитуваль-
ником HAQ, а інтенсивність хвороби – за шкалою DAS28.
Потенціали P300 ініціювали акустичною стимуляцією
відповідно до oddball-парадигми та відводили від точок
Fz та Cz. Усереднені значення латентних періодів хвилі
P300 в групах RA та C не демонстрували якихось істотних
відмінностей. У той же час усереднені амплітуди P300 в
обох кортикальних зонах у групі RA були вірогідно нижчи-
ми (P < 0.05), ніж відповідні величини в групі C. Таким чи-
ном, існує статистично значуща різниця між характеристи-
ками когнітивного ППП P300 у пацієнтів із ревматоїдним
артритом та здорових суб’єктів, що вказує на негативні
зміни сенсорного процесінга та уваги, а також когнітивні
дисфункції, виниклі під впливом хронічного болю.
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