Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons Via Inhibition of Intracellular Phosphodiesterase

• Published in: Нейрофизиология
• Date: 2015
• Main Authors: Yang, J.Y., Yang, G., Ren, J., Zhao, J., Li Sh.
• Format: Article
• Language: English
• Published: Інститут фізіології ім. О.О. Богомольця НАН України 2015
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/148186
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Caffeine Suppresses GABA Receptor-Mediated Current in Rat Primary Sensory Neurons Via Inhibition of Intracellular Phosphodiesterase / J.Y. Yang, G. Yang, J. Ren, J. Zhao, Sh. Li // Нейрофизиология. — 2015. — Т. 47, № 2. — С. 129-135. — Бібліогр.: 25 назв. — англ.

In acutely isolated rat primary sensory neurons, the effects of caffeine on GABA receptormediated current (IGABA) were investigated using a whole-cell patch clamp technique. We found that applications of GABA (10-1000 µM) induced inward currents in a concentration-dependent manner; the currents ma...