Neuroprotective Effect of Vitamin E in a Kainate-Induced Rat Model of Temporal Lobe Epilepsy

• Datum: 2014
• Hauptverfasser: Kiasalari, Z., Khalili, M., Roghani, M.
• Format: Artikel
• Sprache: English
• Veröffentlicht: Інститут фізіології ім. О.О. Богомольця НАН України 2014
• Schriftenreihe: Нейрофизиология
• Online Zugang: https://nasplib.isofts.kiev.ua/handle/123456789/148265
• Назва журналу: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Zitieren: Neuroprotective Effect of Vitamin E in a Kainate-Induced Rat Model of Temporal Lobe Epilepsy / Z. Kiasalari, M. Khalili, M. Roghani // Нейрофизиология. — 2014. — Т. 46, № 2. — С. 141-148. — Бібліогр.: 46 назв. — англ.

Temporal lobe epilepsy (TLE) is known as the most common form of epilepsy in adults and as the type most resistant to treatment. Neuroprotective treatments are considered as a promising therapy for preventing and treating TLE. We investigated the possible neuroprotective effect of vitamin E in an intrahippocampal kainate model of TLE in rats. Kainate injection caused a higher incidence rate of seizures, and vitamin E pretreatment significantly attenuated this index. Intrahippocampal kainate also led to elevation of the malondialdehyde and nitrite/ nitrate levels and lowered superoxide dismutase (SOD) activity, while vitamin E significantly restored MDA and SOD indices. In addition, intrahippocampal kainate induced a significant degeneration of neurons in the CA1, CA3, and hilar regions of the hippocampus; vitamin E considerably attenuated these changes. Timm staining data demonstrated mossy fiber sprouting (MFS) in the dentate gyrus of kainate-lesioned rats, and vitamin E significantly lowered the MFS intensity. Our data suggest that vitamin E pretreatment is capable of attenuating seizures and inhibiting hippocampal neuronal loss and MFS in the kainate-induced model of TLE. A part of the beneficial vitamin E effects is due to its potential to mitigate oxidative stress.