Stress-Induced Increases in the Levels of Caspases in the Prefrontal Cortex in a Rat Model of PTSD
We investigated the levels of expression of caspase-3 and 9 in the medial prefrontal cortex (mPFC) of rats subjected to single prolonged stress (SPS), trying to provide a novel insight into the mechanism of how this cortical region is related to post-traumatic stress disorder (PTSD). Fifty male W...
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| Date: | 2016 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Інститут фізіології ім. О.О. Богомольця НАН України
2016
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| Series: | Нейрофизиология |
| Online Access: | https://nasplib.isofts.kiev.ua/handle/123456789/148322 |
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| Journal Title: | Digital Library of Periodicals of National Academy of Sciences of Ukraine |
| Cite this: | Stress-Induced Increases in the Levels of Caspases in the Prefrontal Cortex in a Rat Model of PTSD / J.H. Zhang, M. Li, F. Han, Yu.X. Shi // Нейрофизиология. — 2016. — Т. 48, № 1. — С. 14-19. — Бібліогр.: 23 назв. — англ. |
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Digital Library of Periodicals of National Academy of Sciences of Ukraine| Summary: | We investigated the levels of expression of caspase-3 and 9 in the medial prefrontal cortex
(mPFC) of rats subjected to single prolonged stress (SPS), trying to provide a novel insight
into the mechanism of how this cortical region is related to post-traumatic stress disorder
(PTSD). Fifty male Wistar rats were divided into the control group and four SPS groups
examined at days 1,4,7, and 14 after treatment. Expression of caspase-3 in SPS groups was
significantly greater when compared with the control group (P < 0.05) and peaked at day
7 after exposure to SPS. In the control group, the intensity of fluorescence of caspase-9-
positive cells was low, while that in the SPS groups was significantly higher (P < 0.01) and
peaked at day 4 after exposure to SPS. After SPS episodes, levels of mRNA of caspase-3 and
caspase-9, compared with those in the control group, gradually increased and peaked at days
7 and 4, respectively (P < 0.01). Therefore, changes of expression of caspase-9 and caspase-3
may play an important role in the pathogenesis of PTSD. |
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