Heterozygous deletions are main cause of expression alterations of PPM1M and PRICLE2 genes in human clear cell renal cell carcinomas

• Date: 2015
• Main Authors: Rudenko, E.E., Lapska, Y.V., Gerashchenko, G.V., Stakhovsky, E.O., Vikarchuk, M.V., Kashuba, V.I.
• Format: Article
• Language: English
• Published: 2015
• Subjects: Structure and Function of Biopolymers
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152430
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Heterozygous deletions are main cause of expression alterations of PPM1M and PRICLE2 genes in human clear cell renal cell carcinomas / E.E. Rudenko, Y.V. Lapska, G.V. Gerashchenko, E.O. Stakhovsky, M.V. Vikarchuk, V.I. Kashuba // Biopolymers and Cell. — 2015. — Т. 31, № 1. — С. 29-33 . — Бібліогр.: 21 назв. — англ.

Aim. To discover the mechanisms of the PPM1M and PRICKLE2 genes expression alterations in clear cell renal cell carcinomas. Methods. Study of the copy number was performed, using the quantitative PCR (Q-PCR). Results. Deletions of PPM1M were found in 55 % of cases, amplifications – in 17 % and in 28...