Topokaryotyping – a proposal for a novel approach to study nuclear organization

• Date: 2015
• Main Authors: Jurisic, A., Robin, C., Ogryzko, V.
• Format: Article
• Language: English
• Published: 2015
• Subjects: Methods
• Online Access: https://nasplib.isofts.kiev.ua/handle/123456789/152436
• Journal Title: Digital Library of Periodicals of National Academy of Sciences of Ukraine
• Cite this: Topokaryotyping – a proposal for a novel approach to study nuclear organization / A. Jurisic, C. Robin, V. Ogryzko // Biopolymers and Cell. — 2015. — Т. 31, № 1. — С. 72-79 . — Бібліогр.: 43 назв. — англ.

Gene positioning in the nucleus plays an important role in gene activity and genome stability, both in norm and pathology. We propose a new principle for the analysis of the large scale chromatin organization at the single-cell level, termed Topokaryotyping. It is based on coexpression in cells of (...